Chad (Qianchuan) He
Appointments and Affiliations
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Degrees
Ph.D., Biostatistics, University of North Carolina, 2012.
Ph.D., Microbiology and Molecular Genetics, Michigan State University, 2005.
M.S., Statistics, Michigan State University, 2004.
B.S., Biology, Beijing University, 1997.
Research Interests
My research is focused on the development of new statistical methods to tackle the high-dimensionality of genomic data. This includes variable selection, dimension reduction and risk prediction for high-throughput genetic studies. I am also interested in multivariate-outcome data analysis, machine learning and quantile regression methods.
Additional Experience
Software Developed
HAPSTAT for special sampling scheme (both in C++ and R), 2007-2008. This software has high power to detect genetic associations by adopting a MLE-based method for haplotype analysis.
HAPSCAN (written in C++), 2009. This program performs sliding-window analysis for large-scale haplotype analysis.
Monte Carlo method for multiple testing adjustment (both in R and C++), 2010. This software employs a Monte-Carlo method to adjust for multiple comparisons in genetic association studies.
Joint analysis for GWAS with multiple phenotypes (in C++), 2011. It provides a statistically powerful tool for analyzing genetic association studies that carry multiple phenotypes.
GWASelect (C++, with parallel computing), 2010. This is a cutting-edge program for disease-gene hunting and genetic risk prediction in the era of personalized medicine.
Variable selection for meta-analysis (written in R), 2011. This software conducts variable selection for meta analysis, either based on raw data or solely based on summary statistics.
A Support Vector Machine Program for genetic risk prediction (written in C++), 2011.
Memberships
American Statistics Association
Eastern North American Region of the International Biometric Society
Honors and Awards
ENAR Distinguished Student Paper Award (Paper Title: Sparse Meta-Analysis With Applications to High-Dimensional Data), 2012.
NIH Research Fellowship, 2005-2006
Graduate Student Research Enhancement Award, Michigan State University, 2003
Ronald M. and Sharon Rogowski Fellowship, Michigan State University, 2003
Recent Publications
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2012. PEGylation is effective in reducing immunogenicity, immunotoxicity, and hepatotoxicity of α-momorcharin in vivo.. Immunopharmacology and immunotoxicology. Abstract
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2012. Alpha-momorcharin possessing high immunogenicity, immunotoxicity and hepatotoxicity in SD rats.. Journal of ethnopharmacology. 139(2):590-8. Abstract
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2012. Fine-mapping and initial characterization of QT interval loci in African Americans.. PLoS genetics. 8(8):e1002870. Abstract
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2011. Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes.. Breast cancer research and treatment. 129(2):593-606. Abstract
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2011. A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.. PLoS genetics. 7(10):e1002322. Abstract
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2011. A variable selection method for genome-wide association studies.. Bioinformatics (Oxford, England). 27(1):1-8. Abstract
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2009. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.. Molecular psychiatry. 14(4):359-75. Abstract
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2005. Inherited motor neuron disease in domestic cats: a model of spinal muscular atrophy.. Pediatric research. 57(3):324-30. Abstract
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2004. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless.. Blood. 103(5):1573-9. Abstract
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2003. Canine Imerslund-Gräsbeck syndrome maps to a region orthologous to HSA14q.. Mammalian genome : official journal of the International Mammalian Genome Society. 14(11):758-64. Abstract
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2003. Congenital hypothyroidism with goiter in toy fox terriers.. Journal of veterinary internal medicine / American College of Veterinary Internal Medicine. 17(1):50-7. Abstract
Shared Resources are core facilities that provide services and access to specialized equipment for research activities.
Paul Woloshin, MBA, Ph.D.
Vice President, Shared Resources
