Laura Beretta

Appointments and Affiliations
 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Cancer Biology
Full Member, Appointed: 2004
University of Washington
School of Public Health and Community Medicine
Global Health
Affiliate Professor, Appointed: 2008
University of Washington
School of Medicine
Pathology
Affiliate Professor, Appointed: 2006
 Professional Headshot of Laura Beretta

Mailing Address

Molecular Diagnostics Program
Division of Public Health Sciences
1100 Fairview Avenue North (M5-A864)
Seattle, Washington 98109
United States

Contact

Phone: (206) 667-7080
Fax: (206) 667-2537
lberetta@fhcrc.org

Degrees

Ph.D., University of Paris VI, Molecular and Cellular Pharmacology, 1989.

Research Interests

Hepatitis C virus (HCV) infection affects 3% of the world population (2% of the US population). HCV persists in the large majority of infected patients. We are using a combination of proteomics and gene silencing technologies to identify cellular proteins involved in HCV replication in hepatocytes. We are also studying HCV-related hepatocellular carcinoma (HCC). The incidence of HCV-associated HCC is rising in the United States and is likely to triple over the next 10 to 20 years. This new trend is largely due to the high prevalence of HCV infection in the population. The overall survival rate of HCC is poor because most patients are diagnosed when the tumor is in an advanced stage. Our group has embarked on a major effort to integrate transcriptomics and proteomics for identifying new markers for early diagnosis of HCC and for identifying defective signaling pathways and their signature in hepatocytic transformation. We are also using mouse models of HCC to identify molecular events associated with hepatocarcinogenesis.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
French: (Fluent, Fluent, Fluent)

Memberships

American Association for the Study of Liver Diseases
American Society of Microbiology

Previous Positions

2003-2004, Associate Professor, University of Michigan - Ann Arbor, Medical School, Microbiology and Immunology
2000-2003, Assistant Professor, University of Michigan - Ann Arbor, Medical School, Microbiology and Immunology
1996-2000, Independent Investigator, INSERM (Institut National de la Sante et de la Recherche Medicale), Curie Cancer Institute

Patents

Upregulation of Interferon gene expression, Patent Number: , 1998, France.

Funding

  • NCI: Markers for HCV-related HCC: plasma profiling, targeted strategies and validation, 2009 to 2014.
  • Johns Hopkins University: Proteomic Approach for Liver Cancer Biomarker Discovery, 2004 to 2004.
  • NIDDK: Novel Markers for HCV-related HCC, 2004 to 2011.
  • NIAID: Functional Analysis of the Role of 4E-BP1 and 4E-BP2 in Translational Control, 2002 to 2008.
  • U.S. HHS National Institutes of Health: The University of Michigan Rheumatic Diseases Core Center, 2001 to 2006.

 

Recent Publications

2012
Elortza, F, Beretta L, Zhang X, He F, Mato JM.  2012.  The 2011 Human Liver Proteome Project (HLPP) Workshop September 5, 2011, Geneva, Switzerland.. Proteomics. 12(1):5-8. Abstract
Shang, S, Plymoth A, Ge S, Feng Z, Rosen HR, Sangrajrang S, Hainaut P, Marrero JA, Beretta L.  2012.  Identification of osteopontin as a novel marker for early hepatocellular carcinoma.. Hepatology (Baltimore, Md.). 55(2):483-90. Abstract
Shang, S, Plymoth A, Ge S, Feng Z, Rosen HR, Sangrajrang S, Hainaut P, Marrero JA, Beretta L.  2012.  Identification of osteopontin as a novel marker for early hepatocellular carcinoma.. Hepatology (Baltimore, Md.). 55(2):483-90. Abstract
2011
Lai, KKY, Shang S, Lohia N, Booth GC, Masse DJ, Fausto N, Campbell JS, Beretta L.  2011.  Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models.. PLoS genetics. 7(6):e1002147. Abstract
Legrain, P, Aebersold R, Archakov A, Bairoch A, Bala K, Beretta L, Bergeron J, Borchers CH, Corthals GL, Costello CE et al..  2011.  The human proteome project: current state and future direction.. Molecular & cellular proteomics : MCP. 10(7):M111.009993. Abstract
Cermelli, S, Ruggieri A, Marrero JA, Ioannou GN, Beretta L.  2011.  Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease.. PloS one. 6(8):e23937. Abstract
2010
Beretta, L.  2010.  Liver proteomics applied to translational research in liver disease and cancer.. Proteomics. Clinical applications. 4(4):359-61.
2009
Olson, KE, Booth GC, Poulin F, Sonenberg N, Beretta L.  2009.  Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2.. Immunology. 128(1 Suppl):e376-84. Abstract
Lee, NP, Chen L, Lin MC, Tsang FH, Yeung C, Poon RT, Peng J, Leng X, Beretta L, Sun S et al..  2009.  Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma.. Journal of proteome research. 8(3):1293-303. Abstract
Parent, R, Qu X, Petit M-A, Beretta L.  2009.  The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivity.. Hepatology (Baltimore, Md.). 49(6):1798-809. Abstract
Beretta, L.  2009.  Comparative analysis of the liver and plasma proteomes as a novel and powerful strategy for hepatocellular carcinoma biomarker discovery.. Cancer letters. 286(1):134-9. Abstract
2008
Zheng, J, Gao X, Mato J, Beretta L, He F.  2008.  Report of the 9th HLPP Workshop October 2007, Seoul, Korea.. Proteomics. 8(17):3420-3. Abstract
Lai, KKY, Kolippakkam D, Beretta L.  2008.  Comprehensive and quantitative proteome profiling of the mouse liver and plasma.. Hepatology (Baltimore, Md.). 47(3):1043-51. Abstract
Yi, X, Luk JM, Lee NP, Peng J, Leng X, Guan X-Y, Lau GK, Beretta L, Fan S-T.  2008.  Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.. Molecular & cellular proteomics : MCP. 7(2):315-25. Abstract
Parent, R, Beretta L.  2008.  Translational control plays a prominent role in the hepatocytic differentiation of HepaRG liver progenitor cells.. Genome biology. 9(1):R19. Abstract
2007
Beretta, L.  2007.  Proteomics from the clinical perspective: many hopes and much debate.. Nature methods. 4(10):785-6.
Parent, R, Kolippakkam D, Booth G, Beretta L.  2007.  Mammalian target of rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth.. Cancer research. 67(9):4337-45. Abstract