Corey Casper

Appointments and Affiliations

 
 
University of Washington
School of Medicine
Medicine
Allergy and Infectious Diseases
Associate Professor, Appointed: 2009
University of Washington
Scientific Program on AIDS-Associated Infections and Malignancies
Center for AIDS Research
Director, Appointed: 2007
Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Division
Clinical Research Division
Public Health Sciences Division
Member, Appointed: 2014
Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Division
UCI/Hutchinson Center Cancer Alliance
Director, Appointed: 2005
Seattle Cancer Care Alliance and the Fred Hutchinson Cancer Research Center
Infection Control
Medical Director, Appointed: 2005
Professional Headshot of Corey  Casper

Mailing Address

1100 Fairview Avenue North
Mailstop M1-B140
Seattle, Washington 98109-1024
United States

Degrees

M.P.H., University of Washington, Epidemiology, 2002.
M.D., Cornell University, Medicine, 1997.

Research Interests

Dr. Casper divides his time between engaging in research, teaching and clinical care. His research efforts focus on the transmission, acquisition, natural history, pathophysiology and treatment of infection-associated cancers with a special focus on human herpesvirus 8 (HHV-8). His immunology work described the first comprehensively-validated serologic assay for detection of antibodies to HHV-8, the original description of neutralizing antibodies to HHV-8 and their role in development of Kaposi Sarcoma (KS), and the characterization of gamma-delta T-cell activity in persons with chronic HHV-infection. He then made the first descriptions of the symptoms and viral replication patterns of HHV-8-infected persons without KS. As part of this work, he studied HHV-8 transmission among couples discordant for HHV-8 infection, and also collaborated with researchers in HIV prevention studies to describe epidemiologic risk factors for acquiring HHV-8 in many different cohorts.

As part of his research into HHV-8, Dr. Casper described the successful use of antiviral therapy for the treatment of multicentric Castleman disease (MCD) and followed this by the first randomized trial of an antiviral against HHV-8. He also utilized information from a large primary HIV clinic to show that the majority of patients with KS in the highly active antiretroviral therapy era have persistent disease, despite the receipt of highly active antiretroviral therapy (HAART) and chemotherapy. This work has informed current and future studies evaluating the role of antiviral drugs in the treatment and prevention of infection-associated cancers.

In 2004, Dr. Casper initiated collaboration with physician-scientists at the Uganda Cancer Institute (UCI) and the Kampala Cancer Registry resulting in the formation of the UCI/Hutchinson Center Cancer Alliance. As Director of this program, based at the Fred Hutchinson Cancer Research Center, he established a translational clinical research site in Kampala. This site currently has 23 ongoing studies examining the control of HHV-8 replication, biomarkers for the prediction of KS development and successful treatment, the immunogenetics of infection-associated cancers, treatment of KS and Burkitt lymphoma, the role of nutrition in the development and treatment of infection-related cancers, and the discovery of novel pathogens associated with cancer. Under Dr. Casper's direction, research is being bolstered with the addition of a new cancer clinic and hospital, a quickly expanding training program, and a state-of-the-art molecular diagnostics laboratory.

Memberships

American Practioners for Infection Control
Centers for Disease Control
Infectious Diseases Society of America
National Comprehensive Cancer Network

Honors and Awards

2007, Young Investigator Award, School of Medicine, University of Washington
2005, Clinical Scientist Development Award, Doris Duke Charitable Foundation
2001-2003, Special Citation for Fellows-in-Training, Infectious Diseases Society of America
2011, Top Doctor, Seattle Metropolitan Magazine, Fred Hutchinson Cancer Research Center
2005, Distinguished Investigator Award, Spanish Association of Rare Diseases/Castleman Disease
2002, Joel Meyers Infectious Diseases Scholarship Award, Fred Hutchinson Cancer Reserch Center
2005, Stephen L. Sacks Investigator Award, American Herpes Foundation

Previous Positions

2010-2013, Associate Member, Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Clinical Research Division and Public Health Sciences Division 
2007-2009, Assistant Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
2006, Lecturer, University of Washington, Conjoint 553: Clinical Management of HIV and STIs
2005-2010, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research and Public Health Sciences Divisions, Vaccine and Infectious Disease Institute
2005-2009, Assistant Professor, University of Washington, School of Medicine, Medicine, Infectious Disease
2003, Subsitute Faculty, University of Washington, Introduction to Clinical Medicine
2002, Section Leader, University of Washington, School of Medicine, Human Biology 530: Epidemiology and Evidence-based Medicine

Funding

  • Seattle Children's Research Institute (SCRI): Oral pathogenesis and host interactions of KSHV infection, 2011 to 2015.
  • National Institutes of Health (NIH): Immunogenetics in the Control of Human Herpesvirus-8 Replication and the Progression to Kaposi Sarcoma, 2011 to 2015.
  • National Institutes of Health (NIH): Cancer Center Support Grant, 2011 to 2012.
  • National Institutes of Health (NIH): Impact of HIV and HHV-8 Co-Infection on Antiretroviral Therapy In Africa, 2010 to 2015.
  • National Institutes of Health (NIH): Building Sustainable Translational Research Teams in HIV-Associated Malignancies, 2010 to 2013.
  • Fred Hutchinson Cancer Reserch Center: Statistical Methods in HIV/AIDS Research, 2010 to 2013.
  • Fred Hutchinson Cancer Reserch Center: Association between HIV and Survival after Cancer Diagnosis, 2010 to 2012.
  • Emmes Corporation: AIDS Malignancy Consortium Clinical Trial Unit, 2010 to 2015.
  • Fred Hutchinson Cancer Reserch Center: Cancer Center Support Grant, 2009 to 2011.
  • National Institutes of Health (NIH): Human Herpesvirus-8 Replication and HIV Progression in Uganda, 2009 to 2011.
  • National Institutes of Health (NIH): Immunogenetics in the Control of Human Herpesvirus-8 Replication and the Progression to Kaposi Sarcoma, 2008 to 2010.
  • University of Washington: AIDS International Training and Research Program, 2008 to 2012.
  • Fred Hutchinson Cancer Reserch Center: Nutrition, Thymic T-Cell Production and Control of HHV-8 and HIV, 2008 to 2012.
  • University of Washington: University of Washington Centers for AIDS Research, 2008 to 2013.

 

Recent Publications

2014
Chu, HY, Englund JA, Podczervinski S, Kuypers J, Campbell AP, Boeckh MJ, Pergam SA, Casper C.  2014.  Nosocomial Transmission of Respiratory Syncytial Virus in an Outpatient Cancer Center.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. Abstract
2013
Ulrickson, M, Okuku F, Walusansa V, Press O, Kalungi S, Wu D, Kambugu F, Casper C, Orem J.  2013.  Cutaneous T-cell lymphoma in sub-Saharan Africa.. Journal of the National Comprehensive Cancer Network : JNCCN. 11(3):275-80. Abstract
2012
Achenbach, CJ, Harrington RD, Dhanireddy S, Crane HM, Casper C, Kitahata MM.  2012.  Reply to letang et Al.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 55(1):158-9.
2011