N.R.C.C., Clinical Chemistry, 1992.
D.A.B.C.C., Clinical Chemistry, 1992.
Clinical Chemistry Fellow, University of Washington, Laboratory Medicine, 1992.
Postdoc Research Associate, Fred Hutchinson Cancer Research Center, Molecular Virology, 1990.
Postdoc Fellow, Fred Hutchinson Cancer Research Center, Biochemistry Oncology, 1986.
Ph.D., University of Washington, Biochemistry, 1982.
M.S., Ohio State University, Botany, 1971.
B.S., National Taiwan University, Botany, 1968.
For most recent work on differentially expressed genes in oral squamous cell carcinoma, please click the homepage link in the Contact Information section on this page.
A major emphasis of my research has been to understand the possible role of metabolic enzymes in the activation and detoxification of potential carcinogens in the environment, as well as steroid hormones and growth factors, in the etiology of cancer. Of particular interest is the contribution of genetic polymorphisms of these enzymes and receptor molecules for hormones and growth factors to susceptibility to cancer.
In collaboration with epidemiologists, my laboratory has been conducting molecular epidemiologic studies to examine the potential association of polymorphisms of certain genes (such as CYP2D6, CYP2E1, GSTM1, GSTP1, GSTT1, microsomal epoxide hydrolase, NAT1, NAT2, NQO1, etc.), that may play an important role in the activation or detoxification of potential carcinogens that are found in tobacco smoke or are derived from food sources, with the incidence of cancers of the oral cavity, nasopharynx, colon, anus, penis, cervix, vagina, and vulva, and of acute myelocytic leukemia. For cancers of the oral cavity, we are also examining their incidence in relation to alcohol consumption and polymorphisms of the alcohol dehydrogenase type 2 and type 3 genes. Recently, we have begun to use microarray technology to examine differential gene expression in oral cancers of different clinical stage.
Collaborative studies pertaining to hormonal carcinogenesis include: (1) polymorphisms of CYP17, CYP1A1, CYP1B1, catechol O-methyltransferase, glutathione S-transferases, and estrogen receptor in relation to the incidence of cancers of the breast and endometrium; (2) polymorphisms of the 5-alpha reductase type II gene (the 5-alpha reductase converts testosterone to a more potent androgen dihydrotestosterone) and the androgen receptor gene in relation to the incidence of prostate cancer; (3) polymorphisms of CYP11a, CYP17, 3-beta HSD type II, CYP3A4 and UGT2B15 and the incidence of testicular cancer.
Other studies pertain to the evaluation of prediagnostic levels of endogenous sex hormones (androstenedione, testosterone, 3 alpha diol glucuronide, estradiol), sex hormone binding globulin, and insulin-like growth factors and polymorphisms of insulin-like growth factor gene and insulin-like growth factor binding protein gene in relation to prostate cancer risk; the dietary influences on the activities of glutathione S-transferases, cytochrome 450 enzymes, and female hormone levels; the transcriptional regulation of glutathione S-transferases, and the evaluation of melatonin metabolism in relation to exposure to magnetic fields.
(Reading, Writing, Speaking)
Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)
Academy of Clinical Laboratory Physicians and Scientists
American Association for Cancer Research
American Association for Clinical Chemistry
Epidemiology of Endometrial Cancer Consortium
International Academy of Oral Oncology
International Head and Neck Cancer Epidemiology Consortium
International Lung Cancer Consortium
International Society for the Studies of Xenobiotics
Honors and Awards
2005, Honoree, Women of Color Empowered, Northwest Asian Foundation
1991, Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists
1983-1986, Postdoctoral Individual National Research Service Award, NCI, NIH
2001-2006, Affiliate Associate Professor, University of Washington, School of Medicine, Otolaryngology: Head and Neck Surgery
2000-2006, Affiliate Associate Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1999-2005, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
1999-1999, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
1995-1999, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Cancer Biology
1992-1997, Founder and Director of Core Laboratory, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Cancer Biology
1992-1993, Clinical Chemist, Providence Hospital
1974-1976, Research Technician II, Case Western Reserve University, Surgery, Opthalmology, Project: Chemistry of Rhodopsin
1972-1972, Medical Mycologist/Microbiologist, W.A. Foote Memorial Hospital, Clinical Laboratory
1972-1974, Senior Research Technician, Michigan State University, Atomic Energy Commission Plant Research Laboratory, Physiology of Abscisic Acid and Xanthoxin
A 13-Gene Signature Prognostic of HPV-Negative OSCC: Discovery and External Validation.. Clinical cancer research : an official journal of the American Association for Cancer Research. 19(5):1197-203.. 2013.
Estrogen Plus Progestin and Breast Cancer Incidence and Mortality in the Women's Health Initiative Observational Study.. Journal of the National Cancer Institute. 105(8):526-35.. 2013.
A history of allergies is associated with reduced risk of oral squamous cell carcinoma.. Cancer causes & control : CCC.. 2012.
Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium.. International journal of cancer. Journal international du cancer. 131(7):1686-99.. 2012.
Examination of ancestral informative markers and self-reported race with tumor characteristics of breast cancer among black and white women.. Breast cancer research and treatment.. 2012.
Estrogen-related genes and their contribution to racial differences in breast cancer risk.. Cancer causes & control : CCC. 23(5):671-81.. 2012.
Smoking cessation, weight gain, and risk of type 2 diabetes mellitus among postmenopausal women.. Archives of internal medicine. 172(5):438-40.. 2012.
Human Papillomavirus-Positive Oral Cavity and Oropharyngeal Cancer Patients Do Not Have Better Quality-of-Life Trajectories.. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2012.
Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.. Cancer causes & control : CCC. 23(1):69-88.. 2012.
Fruit and vegetable intakes in relation to plasma nutrient concentrations in women in Shanghai, China.. Public health nutrition. 15(1):167-175.. 2012.
History of Diabetes and Risk of Head and Neck Cancer: A Pooled Analysis from the International Head and Neck Cancer Epidemiology Consortium.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(2):294-304.. 2012.
Age at Last Birth in Relation to Risk of Endometrial Cancer: Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium.. American journal of epidemiology. 176(4):269-278.. 2012.
Integrative Analysis in Oral Squamous Cell Carcinoma Reveals DNA Copy Number-Associated miRNAs Dysregulating Target Genes.. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2012.
Night Shift Work and Hormone Levels in Women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(4):609-618.. 2012.
Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers.. International journal of molecular epidemiology and genetics. 3(1):1-17.. 2012.
Polymorphisms in Nucleotide Excision Repair Genes and Endometrial Cancer Risk.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(9):1873-1882.. 2011.
Pregnancy history and risk of endometrial cancer.. Epidemiology (Cambridge, Mass.). 22(5):638-45.. 2011.
Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers.. Cancer causes & control : CCC. 22(3):449-61.. 2011.
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.. PLoS genetics. 7(3):e1001333.. 2011.