Chu Chen

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Epidemiology
Full Member, Appointed: 2005
University of Washington
School of Medicine
Otolaryngology: Head & Neck Surgery
Affiliate Professor, Appointed: 2006
University of Washington
School of Public Health and Community Medicine
Epidemiology
Affiliate Professor, Appointed: 2006
University of Washington
School of Public Health and Community Medicine
Epidemiology
Graduate School Faculty, Appointed: 1997
Professional Headshot of Chu  Chen

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North
P.O. Box 19024
Mail Stop M5-C800
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-6644
Fax: (206) 667-2537
cchen@fhcrc.org
http://labs.fhcrc.org/chen/index.html
 

Degrees

N.R.C.C., Clinical Chemistry, 1992.
D.A.B.C.C., Clinical Chemistry, 1992.
Clinical Chemistry Fellow, University of Washington, Laboratory Medicine, 1992.
Postdoc Research Associate, Fred Hutchinson Cancer Research Center, Molecular Virology, 1990.
Postdoc Fellow, Fred Hutchinson Cancer Research Center, Biochemistry Oncology, 1986.
Ph.D., University of Washington, Biochemistry, 1982.
M.S., Ohio State University, Botany, 1971.
B.S., National Taiwan University, Botany, 1968.

Research Interests

For most recent work on differentially expressed genes in oral squamous cell carcinoma, please click the homepage link in the Contact Information section on this page.

A major emphasis of my research has been to understand the possible role of metabolic enzymes in the activation and detoxification of potential carcinogens in the environment, as well as steroid hormones and growth factors, in the etiology of cancer. Of particular interest is the contribution of genetic polymorphisms of these enzymes and receptor molecules for hormones and growth factors to susceptibility to cancer.

In collaboration with epidemiologists, my laboratory has been conducting molecular epidemiologic studies to examine the potential association of polymorphisms of certain genes (such as CYP2D6, CYP2E1, GSTM1, GSTP1, GSTT1, microsomal epoxide hydrolase, NAT1, NAT2, NQO1, etc.), that may play an important role in the activation or detoxification of potential carcinogens that are found in tobacco smoke or are derived from food sources, with the incidence of cancers of the oral cavity, nasopharynx, colon, anus, penis, cervix, vagina, and vulva, and of acute myelocytic leukemia. For cancers of the oral cavity, we are also examining their incidence in relation to alcohol consumption and polymorphisms of the alcohol dehydrogenase type 2 and type 3 genes. Recently, we have begun to use microarray technology to examine differential gene expression in oral cancers of different clinical stage.

Collaborative studies pertaining to hormonal carcinogenesis include: (1) polymorphisms of CYP17, CYP1A1, CYP1B1, catechol O-methyltransferase, glutathione S-transferases, and estrogen receptor in relation to the incidence of cancers of the breast and endometrium; (2) polymorphisms of the 5-alpha reductase type II gene (the 5-alpha reductase converts testosterone to a more potent androgen dihydrotestosterone) and the androgen receptor gene in relation to the incidence of prostate cancer; (3) polymorphisms of CYP11a, CYP17, 3-beta HSD type II, CYP3A4 and UGT2B15 and the incidence of testicular cancer.

Other studies pertain to the evaluation of prediagnostic levels of endogenous sex hormones (androstenedione, testosterone, 3 alpha diol glucuronide, estradiol), sex hormone binding globulin, and insulin-like growth factors and polymorphisms of insulin-like growth factor gene and insulin-like growth factor binding protein gene in relation to prostate cancer risk; the dietary influences on the activities of glutathione S-transferases, cytochrome 450 enzymes, and female hormone levels; the transcriptional regulation of glutathione S-transferases, and the evaluation of melatonin metabolism in relation to exposure to magnetic fields.

Languages

(Reading, Writing, Speaking)

Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

Academy of Clinical Laboratory Physicians and Scientists
American Association for Cancer Research
American Association for Clinical Chemistry
Epidemiology of Endometrial Cancer Consortium
International Academy of Oral Oncology
International Head and Neck Cancer Epidemiology Consortium
International Lung Cancer Consortium
International Society for the Studies of Xenobiotics

Honors and Awards

2005, Honoree, Women of Color Empowered, Northwest Asian Foundation
1991, Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists
1983-1986, Postdoctoral Individual National Research Service Award, NCI, NIH

Previous Positions

2001-2006, Affiliate Associate Professor, University of Washington, School of Medicine, Otolaryngology: Head and Neck Surgery
2000-2006, Affiliate Associate Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1999-2005, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
1999-1999, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
1995-1999, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Cancer Biology
1992-1997, Founder and Director of Core Laboratory, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Cancer Biology
1992-1993, Clinical Chemist, Providence Hospital
1974-1976, Research Technician II, Case Western Reserve University, Surgery, Opthalmology, Project: Chemistry of Rhodopsin
1972-1972, Medical Mycologist/Microbiologist, W.A. Foote Memorial Hospital, Clinical Laboratory
1972-1974, Senior Research Technician, Michigan State University, Atomic Energy Commission Plant Research Laboratory, Physiology of Abscisic Acid and Xanthoxin

Funding

  • NIH/NCI R01 CA85064: IGF-1 Levels and the Incidence of Prostate Cancer. PI: Noel S. Weiss, Role on Project: Co-Investigator, $722,389, 7/14/00 to 12/31/03.
  • NIH/NCI R01 CA75332: Diet, Cell Proliferation, and Breast Cancer in Shanghai. PI: David Thomas, Role on Project: Co-Investigator, $363,782, 7/01/97 to 6/30/02.
  • NIH/NCI R01 HD40398: Reproductive and Hormonal Risk Factors for Adenomyosis. PI: Victoria Holt, Role on Project: Co-Investigator, $1,984,349, 3/1/02 to 1/31/07.
  • NIH/NCI R01 CA111703: Molecular Epidemiology of Lung Cancer, Role on Project: Principal Investigator, $1,270,390, 2006 to 2010.
  • NIH/NCI R01 CA112523: Steroid Hormone Genes and Ovarian Cancer Risk, PI: MaryAnne Rossing, Role on Project: Co-Investigator, $1,913,589, 2006 to 2011.
  • NIH/NIEHS/NCI R01 CA104786: Environment, Gene & Testicular Cancer, PI: Tongzhang Zheng (Yale University), Role on Project: PI of Subcontract, $188,575, 2006 to 2011.
  • NIH/NCI, 5 R01 CA85914: Molecular Epidemiology of Testicular Carcinoma (Supplement), PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $2,844,513, 2005 to 2010.
  • NIH/NCI R01 CA105212: Molecular Epidemiology of Endometrial Cancer. Role on Project: Principal Investigator, $1,255,730, 2004 to 2008.
  • NIH/NCI R01 CA95419: Oral Cancer: Molecular Profiles & Clinical Outcomes. Role on Project: Principal Investigator, $2,523,488, 2003 to 2008.
  • NIH R01 CA97090: Night Shift Workers and Hormone Levels in Women, PI: Scott Davis, Role on Project: Co-Investigator, $1,471,412, 2002 to 2007.
  • NIH/NCI R03 CA99897: Insulin-like Growth Factors and Esophageal Adenocarcinoma. PI: Thomas Vaughan, Role on Project: Co-Investigator, $100,000, 2002 to 2004.
  • NIH/NCI R01 CA78812: Endogenous Sex Hormones, Genetics, and Prostate Cancer, Role on Project: Principal Investigator, $988,629, 1999 to 2003.
  • NIH/NCI N01 WH22110: Clinical Coordinating Center for the Clinical Trial and Observation of the Women's Health Initiative. PI: Ross Prentice, Role on Project: Investigator, $150,185,267, 1992 to 2007.
  • F32 CA07491, Recipient of Individual National Research Service Award: GM3 Sialytransferase and Cell Transformation. Role on Project: Principal Investigator, $59,736, 11/03/83 to 11/02/86.
  • NIH/NCI R03 CA80636: Endometrial Cancer and CYP1A1, GSTM1 & T1 Polymorphisms. Role on Project: Principal Investigator, $100,000, 10/01/98 to 8/31/01,.
  • NIH/NCI R01 CA95790: Persistent Organochlorines and Testicular Cancer Risk. PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $800,000, 09/27/01 to 2006.
  • NIH R01 DE12609: Oral Cancer: DNA Polymorphisms in Carcinogen Metabolism. PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $1,058,643, 09/01/98 to 06/30/02.
  • NIH R01 CA80346: 60-Hz Magnetic Fields and Hormone Levels in Women. PI: Scott Davis, Role on Project: Co-Investigator, $1,234,735, 09/01/98 to 3/31/02.
  • NIH/NIEHS R01 ES08305: Phytoestrogens, Organochlorines, and Fibroid Risk. PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $665,420, 09/01/96 to 08/31/01.
  • NIH/NICHD R01 HD33792: Reproductive/Contraceptive Risk Factors & Endometriosis. PI: Victoria Holt, Role on Project: Co-Investigator, $445,874, 07/01/99 to 04/30/03.
  • NIH/NCI N01 HD23166: Breast Cancer & the Birth Control Pill: Case-Control Study of Perimenopausal & Past Oral Contraceptive Use. PI: Janet Daling, $7,811,162. Supplement: Genetic Susceptibility & Risk of Breast Cancer, PI: Kathleen Malone, Role on Project: Co-Investigator, $99,535, 07/01/98 to 9/29/03.
  • NIH/NCI R01 CA85914: Molecular Epidemiology of Testicular Carcinoma. PI: Stephen M. Schwartz, Role on Project: Co-Investigator, $2,941,143, 06/01/00 to 05/31/05.
  • NIH R01 ES06728: Glutathione S-transferases and Anogenital Cancers, Role on Project: Principal Investigator, $725,988, 05/1/94 to 04/30/97.
  • NIH/NCI R01 CA84141: Breast Cancer and Gene Polymorphisms in Chinese Women. Role on Project: Principal Investigator, $818,101, 04/01/01 to 2006.
  • NIH R03 CA91251: Adiposity Related Biomarkers and Breast Tumor Size, PI: Kathleen Malone, Role on Project: Co-Investigator, $171,905, 04/01/01 to 03/31/03.
  • EPA R829438: Persistent Organic Pollutants and Endometriosis Risk, PI: Victoria Holt, Role on Project: Co-Investigator, $966,841, 03/28/02 to 2006.
  • NCI Contract 263-MQ-822580: Prostate Cancer in Chinese Men, PI: Ann Hsing. Role on Project: Principal Investigator of Lab Component, $80,080, 02/01/99 to 08/31/99.
  • NIH/NCI R21 CA66186, Parent Project PI: David Thomas: Estrogen Receptor Polymorphisms and Breast Cancer in Young Women: A Pilot Project, Role on Project: Principal Investigator, $15,415, 01/01/98 to 12/31/98.
  • NIH/NCI R21 CA66186, Parent Project PI: David Thomas: Effects of Soy and Wheat Bran Feeding on Serum and Urinary Steroid Hormone Levels in Premenopausal Women: A Pilot Project, Role on Project: Principal Investigator, $15,000, 01/01/96 to 12/31/96.
  • NIH R01 CA70913: Glutathione Transferases in Humans: Dietary Influences, PI: Johanna Lampe, Role on Project: Co-Investigator, $1,877,846, 01/01/02 to 2006.

 

Recent Publications

2014
Marks, MA, Chaturvedi AK, Kelsey K, Straif K, Berthiller J, Schwartz SM, Smith E, Wyss A, Brennan P, Olshan AF et al..  2014.  Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 23(1):160-71. Abstract
2013
Mirick, DK, Bhatti P, Chen C, Nordt F, Stanczyk FZ, Davis S.  2013.  Night Shift Work and Levels of 6-Sulfatoxymelatonin and Cortisol in Men.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Lohavanichbutr, P, Méndez E, Holsinger CF, Rue TC, Zhang Y, Houck J, Upton MP, Futran N, Schwartz SM, Wang P et al..  2013.  A 13-Gene Signature Prognostic of HPV-Negative OSCC: Discovery and External Validation.. Clinical cancer research : an official journal of the American Association for Cancer Research. 19(5):1197-203. Abstract
Setiawan, VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang Y-B, Wolk A, Wentzensen N, Weiss NS, Webb PM et al..  2013.  Type I and II Endometrial Cancers: Have They Different Risk Factors? Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 31(20):2607-18. Abstract
2012