Bruce E. Clurman
M.D., Cornell University, Medicine, 1989.
Ph.D., Cornell University, Medical Sciences, 1988.
B.A., University of Virginia, Philosophy, 1981.
My lab's research focuses on two areas: 1) normal cell cycle control in mammalian cells, and how the relationships between abnormal cell division and tumorigenesis, and 2) mechanisms of ubiquitin-mediated proteolysis and the role of ubiquitin ligases in cancer. We use a broad range of approaches, including gene targeting in human cells and mice, biochemistry, proteomics, developing new methods of phosphoproteome analysis, and high throughput RNAi and drug screening.
My clinical practice is largely restricted to hematopoietic stem cell transplantation.
Stem Cell Transplantation
American Society for Clinical Investigation
Honors and Awards
2006-2011, Scholar in Translational Research, Burroughs Welcome Fund, Fred Hutchinson Cancer Research Center
1999-2005, Distinguished Young Scholar in Medical Research, W.M. Keck Foundation, Fred Hutchinson Cancer Research Center
1997-2000, James S. McDonnell Foundation Scholar, James S. McDonnell Foundation, Fred Hutchinson Cancer Research Center
1994, Jose Carreras Fellowship, Jose Carreras Foundation, Fred Hutchinson Cancer Research Center
1994, Young Investigator Award, American Society of Clinical Oncology, Fred Hutchinson Cancer Research Center
1994-1999, Clinical Investigator Award, National Cancer Institute, Fred Hutchinson Cancer Research Center
1985, Horsfall Award for Outstanding Academic Achievement, Memorial Sloan-Kettering Cancer Center, Cornell University
1981-1988, Rudin Foundation Medical Scientist Fellowship, Sloan Kettering Institute, Cornell University
Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.. Proceedings of the National Academy of Sciences of the United States of America. 110(22):8954-9.. 2013.
Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.. Cell. 153(1):206-15.. 2013.
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.. Genes & development. 27(2):151-6.. 2013.
Phosphorylation of Eukaryotic Elongation Factor 2 (eEF2) by Cyclin A-Cyclin-Dependent Kinase 2 Regulates Its Inhibition by eEF2 Kinase.. Molecular and cellular biology. 33(3):596-604.. 2013.
Fbw7 dimerization determines the specificity and robustness of substrate degradation.. Genes & development. 27(23):2531-6.. 2013.
Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer.. Molecular and cellular biology. 32(11):2160-7.. 2012.
Hypoxia-Inducible Factor 1 Is Activated by Dysregulated Cyclin E during Mammary Epithelial Morphogenesis.. Molecular and cellular biology. 31(18):3885-95.. 2011.
Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.. Molecular and cellular biology. 31(6):1214-24.. 2011.
Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma.. PloS one. 6(3):e14758.. 2011.
Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase.. The Journal of cell biology. 181(6):913-20.. 2008.
Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.. Genes & development. 22(12):1677-89.. 2008.
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.. Nature reviews. Cancer. 8(2):83-93.. 2008.
Identification of CDK2 substrates in human cell lysates.. Genome biology. 9(10):R149.. 2008.
A mechanism misregulating p27 in tumors discovered in a functional genomic screen.. PLoS genetics. 3(12):e219.. 2007.
Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.. Proceedings of the National Academy of Sciences of the United States of America. 99(17):11293-8.. 2002.