Larry Corey

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
President and Director
Clinical Research Division
Member
Public Health Sciences Division
Member
Vaccine and Infectious Disease Division
Member
University of Washington
School of Medicine
Medicine
Allergy and Infectious Diseases
Professor, Appointed: 1984
University of Washington
School of Medicine
Laboratory Medicine
Virology
Professor
University of Washington
School of Medicine
Laboratory Medicine
Holder of Lawrence Corey Endowed Chair in Medical Virology
Professional Headshot of Larry Corey

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N.
P.O. Box 19024
D1-060
Seattle, Washington 98109-1024
United States

Degrees

Fellowship, University of Washington, Infectious Diseases, 1977.
EIS Officer, Centers for Disease Control and Prevention (CDC), Internal Medicine Training, 1975.
Residency, University of Michigan, Medical Center Hospitals, Internal Medicine, 1973.
M.D., University of Michigan, 1971.

Research Interests

The herpes virus research program at the University of Washington involves studies in HSV, CMV, HHV-6 and HHV-8. The genital HSV program has been the most longstanding, having had continuous NIH funding since 1978. This program involves clinical investigations of HSV reactivation and transmission, laboratory based studies on the cellular immunology of HSV, and characterization of HSV-HIV interactions. In the last few years, the laboratory has focused on developing an HSV vaccine by defining the T-cell responses to HSV, especially cytotoxic T-cell responses as a means of developing CTL-based vaccines for immunotherapy or prophylaxis of genital HSV. The laboratory based programs involve collaborations with Drs. Jia Zhu, Research Assistant Professor; David Koelle, Professor of Medicine; Keith Jerome, Professor of Laboratory Medicine, University of Washington and now Head of the Diagnostic Virology Division; and Christine Posavad, Senior Scientist at the Hutchinson Center. The Clinical Research Program in genital herpes is directed by Dr. Anna Wald, Professor of Medicine, University of Washington and Dr. Christine Johnston, Assistant Professor of Medicine, University of Washington. Dr. Wald is medical director of the Viral Disease Clinic, a specialty clinic dedicated to a wide range of clinical studies on HSV infection, including resolution frequency, vaccine efficacy and technology development.

The program in HHV-8 infection encompasses studies of the transmission of HHV-8 and the mechanism by which HHV-8 induces Kaposi’s sarcoma. This work is done with Dr. Corey Casper, Associate Member at the Hutchinson Center. Clinical trials for HHV-8 prevention are conducted in the newly formed Uganda Program on Cancer and Infectious Diseases under the direction of Dr. Orem Jackson of the Uganda Cancer Institute and Dr. Corey Casper and Dr. Warren Phipps at the Hutchinson Center.

The Vaccine and Infectious Disease Division (VIDD) of the Hutchinson Center is home to many researchers studying prevention of CMV and HHV-6 infections in the immunocompromised host and the role these infections play in the morbidity of HSCT. Dr. Michael Boeckh, Professor of Medicine heads research on CMV infection in collaboration with Dr. Steven Pergam, Associate Professor in Medicine.

The HIV research program directed by Dr. Corey includes both laboratory and clinical investigation. Dr. Corey is the co-PI of the NIAID supported HIV Vaccine Trials Network (HVTN), a global network of clinical trial sites and laboratories dedicated to phase I-III trials of candidate HIV vaccines and other preventative and treatment options. Other faculty members involved in the effort are Drs. Juliana McElrath, Peter Gilbert and Jim Kublin. Training opportunities for postdoctoral fellows interested in learning vaccine biology and clinical trial research are available within the network.

Additional Experience

Dr. Corey is a member of numerous committees and editorial boards in areas of infectious diseases, HIV infection, and HIV vaccines. He is a member of the National Cancer Institute Board of Scientific Counselors, Basic Sciences.

Memberships

American Epidemiological Society
American Federation for Clinical Research
American Society of Clinical Investigation
Association of American Physicians
Infectious Diseases Society of America
Institute of Medicine
Western Association of Physicians

Honors and Awards

2012, Recipient, 2012 Cubist-ICAAC Award, American Society for Microbiology
2012, Elected, Member, American Academy of Arts and Sciences
2011, Lifelong AIDS Alliance "Ned Behnke Leadership Award"
2008, Elected, National Academy of Sciences, Institute of Medicine, National Academy of Sciences

Previous Positions

2007-2010, Co-Director, Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
2007-2010, Senior Vice President, Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division
1996-2010, Head, Fred Hutchinson Cancer Research Center, Clinical Research Division, Infectious Disease Sciences
1978-2010, Head, Virology Division, Department of Laboratory Medicine, School of Medicine, University of Washington

 

Recent Publications

2014
2013
2012
Zerr, DM, Boeckh MJ, Delaney C, Martin PJ, Xie H, Adler AL, Huang M-L, Corey L, Leisenring WM.  2012.  HHV-6 Reactivation and Associated Sequelae after Hematopoietic Cell Transplant.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 18(11):1700-1708. Abstract