Janet R. Daling

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Member
University of Washington
School of Public Health and Community Medicine
Epidemiology
Professor, Appointed: 1986
Professional Headshot of Janet R. Daling

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N. M4-C308
PO Box 19024
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-4630
Fax: (206) 667-5948
jdaling@fhcrc.org

Degrees

Ph.D., University of Washington, Epidemiology, 1977.
M.S., University of Washington, Biostatistics, 1973.
B.A., Washington State University, Mathematics, 1957.

Research Interests

My expertise is in the following area:

Etiology And Genetics Of Breast Cancer - A major emphasis of my research in recent years has been breast cancer. Working with Dr. Kathleen Malone, we have completed interviews on 1,400 women who were diagnosed with breast cancer before age 45 during the years 1983-1992 and a similar number of general population controls. A primary interest in these studies was the role of oral contraceptive use and induced abortion in the etiology of these tumors. Currently, we are funded to follow-up this cohort of women to determine their survival and relate it to tumor markers as well as patient characteristics and exposures. This cohort, as well as their control group, also are the focus of family studies looking at the genetics of breast cancer. We are also using DNA samples collected from these women and their controls to assess the role that the BRCA1, BRCA2 and AT genes play in this disease and to identify other genes. These studies are done in collaboraton with Drs. Peggy Porter, Elaine Ostrander, and Lue Ping Zhao.

We are also participating in a seven-year multicenter case-control study of breast cancer in women 35-64 years of age. The FHCRC study site is the genetics coordinating center for this study. This study,which includes 5,500 breast cancer cases and 5,500 controls, has as its primary goal to evaluate the risk of breast cancer associated with use of both oral contraceptives and hormone replacement therapy. Although previous studies have shown only modest increases in risk, if any, associated with oral contraceptive use, the risk associated use of both oral contraceptives and hormone replacement therapy can only now be evaluated. This study also has the goal to contrast risk factors for breast cancer in African Americans and Caucasians. One third of the study population is African American.

Additional Experience

A second major interest we have had is evaluating the role of human papilloma viruses (HPVs) in the etiology of anogenital cancers; i.e., cervix, vulva, vagina, anal and penile. Although we now know the infection with HPV is necessary for the developmentof these tumors, since infection with HPV is relatively common, other exposures or patient characteristics are necessary for cancer to occur. One co-factor we have identified is being a cigarette smoker at diagnosis. We are exploring this association by looking for genetic susceptibility markers among our cases, particularly those that may be involved in the metabolism and detoxification of the active metabolities of the carcinogenics in tobacco. The gluathione S-transferases and debrisoquine hydroxylasegenes are currently being studied. These studies are done in collaboration with Drs. Steve Schwartz, Chu Chen, Denise Galloway, and James McDougall. Studies of thyroid cancer, prostate cancer, ovarian cysts and neoplasms, ovarian cancer, and uterine leiomyomas are also research topics that I
collaborate on with other faculty members in our group.

Memberships

American Epidemiological Society
Public Health Association
Society for Epidemiologic Research

Previous Positions

1983-1986, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Dept. of Epidemiology
1981-1983, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1981-1983, Associate Professor, University of Washington, School of Public Health and Community Medicine, Dept. of Epidemiology
1978-1982, Assistant Professor, University of Washington, Dept. of Epidemiology, School of Public Health and Comm. Med.
1978-1981, Associate in Epidemiology, Fred Hutchinson Cancer Research Center, Dept. of Epidemiology, Public Health Sciences
1977-1978, Chronic Disease Epidemiologist, State of Washington, Dept. of Social and Health Services, Division of Health
1967-1976, Research Analyst, State of Washington, Dept. of Social and Health Services, Division of Health

 

Recent Publications

2014
2013
2012
2011
Huang, Y, Malone KE, Cushing-Haugen KL, Daling JR, Li CI.  2011.  Relationship between menopausal symptoms and risk of postmenopausal breast cancer.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(2):379-88. Abstract
Malone, KE, Daling JR, Doody DR, O'Brien C, Resler A, Ostrander EA, Porter PL.  2011.  Family History of Breast Cancer in Relation to Tumor Characteristics and Mortality in a Population-Based Study of Young Women with Invasive Breast Cancer.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(12):2560-2571. Abstract
2010
2009
Reding, KW, Weiss NS, Chen C, Li CI, Carlson CS, Wilkerson H-W, Farin FM, Thummel KE, Daling JR, Malone KE.  2009.  Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(5):1461-7. Abstract