Janet R. Daling
Ph.D., University of Washington, Epidemiology, 1977.
M.S., University of Washington, Biostatistics, 1973.
B.A., Washington State University, Mathematics, 1957.
My expertise is in the following area:
Etiology And Genetics Of Breast Cancer - A major emphasis of my research in recent years has been breast cancer. Working with Dr. Kathleen Malone, we have completed interviews on 1,400 women who were diagnosed with breast cancer before age 45 during the years 1983-1992 and a similar number of general population controls. A primary interest in these studies was the role of oral contraceptive use and induced abortion in the etiology of these tumors. Currently, we are funded to follow-up this cohort of women to determine their survival and relate it to tumor markers as well as patient characteristics and exposures. This cohort, as well as their control group, also are the focus of family studies looking at the genetics of breast cancer. We are also using DNA samples collected from these women and their controls to assess the role that the BRCA1, BRCA2 and AT genes play in this disease and to identify other genes. These studies are done in collaboraton with Drs. Peggy Porter, Elaine Ostrander, and Lue Ping Zhao.
We are also participating in a seven-year multicenter case-control study of breast cancer in women 35-64 years of age. The FHCRC study site is the genetics coordinating center for this study. This study,which includes 5,500 breast cancer cases and 5,500 controls, has as its primary goal to evaluate the risk of breast cancer associated with use of both oral contraceptives and hormone replacement therapy. Although previous studies have shown only modest increases in risk, if any, associated with oral contraceptive use, the risk associated use of both oral contraceptives and hormone replacement therapy can only now be evaluated. This study also has the goal to contrast risk factors for breast cancer in African Americans and Caucasians. One third of the study population is African American.
A second major interest we have had is evaluating the role of human papilloma viruses (HPVs) in the etiology of anogenital cancers; i.e., cervix, vulva, vagina, anal and penile. Although we now know the infection with HPV is necessary for the developmentof these tumors, since infection with HPV is relatively common, other exposures or patient characteristics are necessary for cancer to occur. One co-factor we have identified is being a cigarette smoker at diagnosis. We are exploring this association by looking for genetic susceptibility markers among our cases, particularly those that may be involved in the metabolism and detoxification of the active metabolities of the carcinogenics in tobacco. The gluathione S-transferases and debrisoquine hydroxylasegenes are currently being studied. These studies are done in collaboration with Drs. Steve Schwartz, Chu Chen, Denise Galloway, and James McDougall. Studies of thyroid cancer, prostate cancer, ovarian cysts and neoplasms, ovarian cancer, and uterine leiomyomas are also research topics that I
collaborate on with other faculty members in our group.
American Epidemiological Society
Public Health Association
Society for Epidemiologic Research
1983-1986, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Dept. of Epidemiology
1981-1983, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1981-1983, Associate Professor, University of Washington, School of Public Health and Community Medicine, Dept. of Epidemiology
1978-1982, Assistant Professor, University of Washington, Dept. of Epidemiology, School of Public Health and Comm. Med.
1978-1981, Associate in Epidemiology, Fred Hutchinson Cancer Research Center, Dept. of Epidemiology, Public Health Sciences
1977-1978, Chronic Disease Epidemiologist, State of Washington, Dept. of Social and Health Services, Division of Health
1967-1976, Research Analyst, State of Washington, Dept. of Social and Health Services, Division of Health
Oral contraceptives and breast cancer risk overall and by molecular subtype among young women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
Use of menopausal hormone therapy and risk of ductal and lobular breast cancer among women 55-74 years of age.. Breast cancer research and treatment.. 2014.
Long-Term Statin Use and Risk of Ductal and Lobular Breast Cancer among Women 55 to 74 Years of Age.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(9):1529-37.. 2013.
Reproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20-44 years of age.. Breast cancer research and treatment. 137(2):579-87.. 2013.
Use of antihypertensive medications and breast cancer risk.. Cancer causes & control : CCC. 24(2):365-71.. 2013.
Use of Antihypertensive Medications and Breast Cancer Risk Among Women Aged 55 to 74 Years.. JAMA internal medicine.. 2013.
Estrogen receptor, progesterone receptor, and HER2-neu expression in first primary breast cancers and risk of second primary contralateral breast cancer.. Breast cancer research and treatment. 135(3):849-55.. 2012.
Cohort Profile: The Skin Cancer After Organ Transplant Study.. International journal of epidemiology.. 2012.
Estrogen-related genes and their contribution to racial differences in breast cancer risk.. Cancer causes & control : CCC. 23(5):671-81.. 2012.
Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: A hybrid case-parent triad and case-control study.. International journal of cancer. Journal international du cancer.. 2012.
Oral contraceptive formulation and risk of breast cancer.. Contraception. 85(4):342-350.. 2012.
Relationship between diabetes and risk of second primary contralateral breast cancer.. Breast cancer research and treatment. 125(2):545-51.. 2011.
Smoking during first pregnancy and breast cancer: a case-control study using Washington State registry data.. Annals of epidemiology. 21(1):53-5.. 2011.
Relationship between menopausal symptoms and risk of postmenopausal breast cancer.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(2):379-88.. 2011.
Family History of Breast Cancer in Relation to Tumor Characteristics and Mortality in a Population-Based Study of Young Women with Invasive Breast Cancer.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(12):2560-2571.. 2011.
Age-related variation in the relationship between menopausal hormone therapy and the risk of dying from breast cancer.. Breast cancer research and treatment. 126(3):749-61.. 2011.
Genus beta human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study.. BMJ (Clinical research ed.). 341:c2986.. 2010.
Adjuvant hormonal therapy for breast cancer and risk of hormone receptor-specific subtypes of contralateral breast cancer.. Cancer research. 69(17):6865-70.. 2009.
Pregnancy outcomes in female childhood and adolescent cancer survivors: a linked cancer-birth registry analysis.. Archives of pediatrics & adolescent medicine. 163(10):879-86.. 2009.
Reproductive outcomes in male childhood cancer survivors: a linked cancer-birth registry analysis.. Archives of pediatrics & adolescent medicine. 163(10):887-94.. 2009.
Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.. American journal of epidemiology. 170(10):1241-9.. 2009.
Relationship between potentially modifiable lifestyle factors and risk of second primary contralateral breast cancer among women diagnosed with estrogen receptor-positive invasive breast cancer.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 27(32):5312-8.. 2009.
Genetic polymorphisms in the catechol estrogen metabolism pathway and breast cancer risk.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(5):1461-7.. 2009.