Anneclaire J. De Roos
Ph.D., University of North Carolina at Chapel Hill, Epidemiology, 2000.
M.P.H., University of California, Berkeley, Epidemiology/Biostatistics, 1995.
B.A., University of California, Los Angeles, Geography, 1990.
Dr. De Roos' research interests and experience are primarily in occupational and environmental exposures to chemicals and radiation as risk factors for cancer, other chronic diseases, and intermediate biologic effects. She has conducted studies of lymphomas, leukemias, autoimmune diseases, childhood cancers, and adult brain tumors.
A focus of Dr. De Roos' research is in health effects of exposure to persistent organic pollutants (POPs). In a study of POPs in plasma as contributors to non-Hodgkin lymphoma (NHL) risk (Cancer Res, 2005), Dr. De Roos and colleagues found that certain moderate- and highly-chlorinated polychlorinated biphenyl (PCB) congeners were associated with two- to three-fold increased risk of NHL (comparing extreme quartiles). The dioxin-like furan compounds measured were also strongly associated with NHL incidence, with a significant trend across quartiles (p=0.006), and the toxic equivalency quotient (TEQ), a summed metric that weights congeners by their dioxin-like potency, was associated with 35% increased risk of NHL per 10 TEQ units. These results suggest that exposures to POPs, particularly dioxin-like POPs and certain non-dioxin-like PCBs, contribute to NHL risk. Dr. De Roos is currently investigating how PCB concentrations change during weight loss in a group of women participating in an exercise intervention trial, and how PCBs may affect immune function in these women.
Dr. De Roos is investigating environmental and occupational exposures in relation to lymphohematopoietic cancers in the Women's Health Initiative (WHI) study, including insecticide exposures and farming history. A possible mechanism by which environmental exposures may contribute to NHL risk is by affecting the immune system, either through immune suppression or B-cell activation and proliferation. In a case-control study nested within the WHI Observational Study, Dr. De Roos is investigating viral and immune markers in prediagnostic biologic samples as predictors of incident NHL. Markers of interest are antibodies to Epstein-Barr virus (EBV) antigens, circulating EBV DNA, and cytokines and other molecules involved in B-lymphocyte response, including IL6, IL10, TNFα, sCD23, sCD27, sCD30, sCD44, and CXCL13.
Several of Dr. De Roos' studies are exploring the use of geographic information systems and geographically-referenced environmental surveillance data to estimate individual-level exposures. One project focuses on environmental exposure to industrial pollution in relation to NHL risk, using data on industry locations, reported emissions, and census data. In another study, Dr. De Roos and investigators at the University of British Columbia are characterizing the possible role of air pollution in the incidence and exacerbation of rheumatoid arthritis in the Vancouver metropolitan region.
International Society for Environmental Epidemiology
Honors and Awards
2001-2001, Intramural Research Award, Division of Cancer Epidemiology and Genetics, National Cancer Institute
2000-2000, Delta Omega National Honor Society in Public Health, Delta Omega National Honor Society
2003-2009, Assistant Professor, University of Washington, School of Public Health, Department of Epidemiology
2003-2008, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
2000-2002, Postdoctoral Fellow, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch
1990-1992, Environmental Scientist, AeroVironment, Inc.
Multiple myeloma and occupation: a pooled analysis by the International Multiple Myeloma Consortium.. Cancer epidemiology. 37(3):300-5.. 2013.
Phthalates and risk of endometriosis.. Environmental research.. 2013.
Investigation of Epstein-Barr Virus as a Potential Cause of B-Cell Non-Hodgkin Lymphoma in a Prospective Cohort.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2013.
Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium.. Cancer causes & control : CCC. 24(1):125-34.. 2013.
Evaluation of seasonality in the diagnosis of acute myeloid leukaemia among adults in the United States, 1992-2008.. British journal of haematology. 160(3):343-50.. 2013.
Associations between allergies and risk of hematologic malignancies:Results from the VITamins and lifestyle (VITAL) cohort study.. American journal of hematology.. 2013.
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.. Nature genetics. 45(8):868-76.. 2013.
Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations.. Journal of exposure science & environmental epidemiology.. 2012.
Poultry and livestock exposure and cancer risk among farmers in the agricultural health study.. Cancer causes & control : CCC. 23(5):663-70.. 2012.
Anthropometric factors, physical activity, and risk of non-Hodgkin's lymphoma in the Women's Health Initiative.. Cancer epidemiology. 36(1):52-9.. 2012.
The relationship between multiple myeloma and occupational exposure to six chlorinated solvents.. Occupational and environmental medicine. 68(6):391-9.. 2011.
Fine Particulate Matter (PM(2.5)) Air Pollution and Immune Status Among Women in the Seattle Area.. Archives of environmental & occupational health. 66(3):155-65.. 2011.
Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants.. Journal of immunotoxicology. 8(1):95-100.. 2011.
A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma.. Environmental health perspectives. 119(2):232-8.. 2011.
Diet and risk of endometriosis in a population-based case-control study.. The British journal of nutrition. 105(3):459-67.. 2011.
Insecticide use and risk of rheumatoid arthritis and systemic lupus erythematosus in the Women's Health Initiative Observational Study.. Arthritis care & research. 63(2):184-94.. 2011.
Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes.. Fertility and sterility. 96(6):1401-1406.e3.. 2011.
Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control study.. Environmental health : a global access science source. 10:63.. 2011.
Non-dioxin-like polychlorinated biphenyls and risk of endometriosis.. Environmental health perspectives. 118(9):1280-5.. 2010.
Incidence of myelodysplastic syndromes within a nonprofit healthcare system in western Washington state, 2005-2006.. American journal of hematology. 85(10):765-70.. 2010.
A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age.. Environmental research. 110(4):388-95.. 2010.
Physical activity, physical exertion, and miscarriage risk in women textile workers in Shanghai, China.. American journal of industrial medicine. 53(5):497-505.. 2010.
Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State.. Occupational and environmental medicine. 67(6):375-86.. 2010.