Anneclaire J. De Roos

Appointments and Affiliations
 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Epidemiology
Associate Member, Appointed: 2008
University of Washington
School of Public Health and Community Medicine
Epidemiology
Associate Professor, Appointed: 2009
University of Washington
School of Public Health
Environmental and Occupational Health Sciences
Adjunct Associate Professor, Appointed: 2009
 Professional Headshot of Anneclaire J. De Roos

Mailing Address

1100 Fairview Avenue N.
P.O. Box 19024
M4-B874
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-7315
Fax: (206) 667-4787
deroos@u.washington.edu

Degrees

Ph.D., University of North Carolina at Chapel Hill, Epidemiology, 2000.
M.P.H., University of California, Berkeley, Epidemiology/Biostatistics, 1995.
B.A., University of California, Los Angeles, Geography, 1990.

Research Interests

Dr. De Roos' research interests and experience are primarily in occupational and environmental exposures to chemicals and radiation as risk factors for cancer, other chronic diseases, and intermediate biologic effects. She has conducted studies of lymphomas, leukemias, autoimmune diseases, childhood cancers, and adult brain tumors.

A focus of Dr. De Roos' research is in health effects of exposure to persistent organic pollutants (POPs). In a study of POPs in plasma as contributors to non-Hodgkin lymphoma (NHL) risk (Cancer Res, 2005), Dr. De Roos and colleagues found that certain moderate- and highly-chlorinated polychlorinated biphenyl (PCB) congeners were associated with two- to three-fold increased risk of NHL (comparing extreme quartiles). The dioxin-like furan compounds measured were also strongly associated with NHL incidence, with a significant trend across quartiles (p=0.006), and the toxic equivalency quotient (TEQ), a summed metric that weights congeners by their dioxin-like potency, was associated with 35% increased risk of NHL per 10 TEQ units. These results suggest that exposures to POPs, particularly dioxin-like POPs and certain non-dioxin-like PCBs, contribute to NHL risk. Dr. De Roos is currently investigating how PCB concentrations change during weight loss in a group of women participating in an exercise intervention trial, and how PCBs may affect immune function in these women.

Dr. De Roos is investigating environmental and occupational exposures in relation to lymphohematopoietic cancers in the Women's Health Initiative (WHI) study, including insecticide exposures and farming history. A possible mechanism by which environmental exposures may contribute to NHL risk is by affecting the immune system, either through immune suppression or B-cell activation and proliferation. In a case-control study nested within the WHI Observational Study, Dr. De Roos is investigating viral and immune markers in prediagnostic biologic samples as predictors of incident NHL. Markers of interest are antibodies to Epstein-Barr virus (EBV) antigens, circulating EBV DNA, and cytokines and other molecules involved in B-lymphocyte response, including IL6, IL10, TNFα, sCD23, sCD27, sCD30, sCD44, and CXCL13.

Several of Dr. De Roos' studies are exploring the use of geographic information systems and geographically-referenced environmental surveillance data to estimate individual-level exposures. One project focuses on environmental exposure to industrial pollution in relation to NHL risk, using data on industry locations, reported emissions, and census data. In another study, Dr. De Roos and investigators at the University of British Columbia are characterizing the possible role of air pollution in the incidence and exacerbation of rheumatoid arthritis in the Vancouver metropolitan region.

Memberships

International Society for Environmental Epidemiology

Honors and Awards

2001-2001, Intramural Research Award, Division of Cancer Epidemiology and Genetics, National Cancer Institute
2000-2000, Delta Omega National Honor Society in Public Health, Delta Omega National Honor Society

Previous Positions

2003-2009, Assistant Professor, University of Washington, School of Public Health, Department of Epidemiology
2003-2008, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
2000-2002, Postdoctoral Fellow, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch
1990-1992, Environmental Scientist, AeroVironment, Inc.

Funding

  • National Institute of Health/National Heart, Lung and Blood Institute: Markers of B-Cell Stimulation as Potential Predictors of Non-Hodgkin Lymphoma, $728,796, 2009 to 2011.
  • National Institute of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases: Role of Air Pollution in Rheumatoid Arthritis Incidence and Exacerbation, $100,000, 2007 to 2009.
  • National Institute of Health/National Institute for Environmental Health Sciences: Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects, $100,000, 2007 to 2009.
  • Amgen, Inc/Global Epidemiology Division: Descriptive Epidemiology of Clinical Course of Myelodysplastic Syndromes (MDS) in a Health Maintenance Organization, $257,768, 2006 to 2008.
  • National Cancer Institute: Transdisciplinary Research in Energetics and Cancer: Energy Balance, Polychlorinated Biphenyl (PCB) Exposure and Possible Toxicologic Effects, $25,000, 2006 to 2007.
  • Fred Hutchinson Cancer Research Center, Hartwell Innovation Fund: Immunotoxicology of Persistent Organochlorine Pollutant Exposure from Weight Loss, $50,000, 2006 to 2007.
  • National Institute of Health/National Cancer Institute: Industrial Pollutants and Risk of Non-Hodgkin's Lymphoma, $100,000, 2005 to 2007.
  • National Cancer Institute/Surveillance, Epidemiology, and End Results (SEER): Descriptive Epidemiology of Clinical Course of Myelodysplastic Syndromes and Potential Space-Time Clustering in Incidence, $69,114, 2005 to 2006.
  • The Arthritis Foundation: Predictors of Work Disability in Rheumatoid Arthritis, $20,000, 1997 to 1999.

 

Recent Publications

2013
Gibson, TM, Smedby KE, Skibola CF, Hein DW, Slager SL, de Sanjosé S, Vajdic CM, Zhang Y, Chiu BC-H, Wang SS et al..  2013.  Smoking, variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma: a pooled analysis within the InterLymph consortium.. Cancer causes & control : CCC. 24(1):125-34. Abstract
Calip, GS, McDougall JA, Wheldon MC, Li CI, De Roos AJ.  2013.  Evaluation of seasonality in the diagnosis of acute myeloid leukaemia among adults in the United States, 1992-2008.. British journal of haematology. 160(3):343-50. Abstract
2012
De Roos, AJ, Mirick DK, Edlefsen KL, LaCroix AZ, Kopecky KJ, Madeleine MM, Magpantay L, Martínez-Maza O.  2012.  Markers of B-Cell Activation in Relation to Risk of Non-Hodgkin Lymphoma.. Cancer research. Abstract
De Roos, AJ, Ulrich CM, Sjodin A, McTiernan A.  2012.  Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations.. Journal of exposure science & environmental epidemiology. Abstract
Beane Freeman, LE, De Roos AJ, Koutros S, Blair A, Ward MH, Alavanja M, Hoppin JA.  2012.  Poultry and livestock exposure and cancer risk among farmers in the agricultural health study.. Cancer causes & control : CCC. 23(5):663-70. Abstract
Kabat, GC, Kim MY, Kim MY, Bea JW, Edlefsen KL, Adams-Campbell LL, De Roos AJ, Rohan TE.  2012.  Anthropometric factors, physical activity, and risk of non-Hodgkin's lymphoma in the Women's Health Initiative.. Cancer epidemiology. 36(1):52-9. Abstract
2011
Gold, LS, Stewart PA, Milliken K, Purdue M, Severson R, Seixas N, Blair A, Hartge P, Davis S, De Roos AJ.  2011.  The relationship between multiple myeloma and occupational exposure to six chlorinated solvents.. Occupational and environmental medicine. 68(6):391-9. Abstract
Williams, L, Ulrich CM, Larson T, Wener MH, Wood B, Chen-Levy Z, Campbell PT, Potter JD, McTiernan A, De Roos AJ.  2011.  Fine Particulate Matter (PM(2.5)) Air Pollution and Immune Status Among Women in the Seattle Area.. Archives of environmental & occupational health. 66(3):155-65. Abstract
Jusko, TA, De Roos AJ, Schwartz SM, Lawrence PB, Palkovicova L, Nemessanyi T, Drobna B, Fabisikova A, Kocan A, Jahnova E et al..  2011.  Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants.. Journal of immunotoxicology. 8(1):95-100. Abstract
Purdue, MP, Bakke B, Stewart P, De Roos AJ, Schenk M, Lynch CF, Bernstein L, Morton LM, Cerhan JR, Severson RK et al..  2011.  A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma.. Environmental health perspectives. 119(2):232-8. Abstract
Trabert, B, Peters U, De Roos AJ, Scholes D, Holt VL.  2011.  Diet and risk of endometriosis in a population-based case-control study.. The British journal of nutrition. 105(3):459-67. Abstract
Parks, CG, Walitt BT, Pettinger M, Chen J-C, De Roos AJ, Hunt J, Sarto G, Howard BV.  2011.  Insecticide use and risk of rheumatoid arthritis and systemic lupus erythematosus in the Women's Health Initiative Observational Study.. Arthritis care & research. 63(2):184-94. Abstract
Trabert, B, Schwartz SM, Peters U, De Roos AJ, Chen C, Scholes D, Holt VL.  2011.  Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes.. Fertility and sterility. 96(6):1401-1406.e3. Abstract
Wheeler, DC, De Roos AJ, Cerhan JR, Morton LM, Severson R, Cozen W, Ward MH.  2011.  Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control study.. Environmental health : a global access science source. 10:63. Abstract
Wang, SS, Lu Y, Rothman N, Abdou AM, Cerhan JR, De Roos AJ, Davis S, Severson RK, Cozen W, Chanock SJ et al..  2011.  Variation in Effects of Non-Hodgkin Lymphoma Risk Factors According to the Human Leukocyte Antigen (HLA)-DRB1*01:01 Allele and Ancestral Haplotype 8.1.. PloS one. 6(11):e26949. Abstract
2010
Trabert, B, De Roos AJ, Schwartz SM, Peters U, Scholes D, Barr DB, Holt VL.  2010.  Non-dioxin-like polychlorinated biphenyls and risk of endometriosis.. Environmental health perspectives. 118(9):1280-5. Abstract
De Roos, AJ, Deeg HJ, Onstad L, Kopecky KJ, Bowles EAJ, Yong M, Fryzek J, Davis S.  2010.  Incidence of myelodysplastic syndromes within a nonprofit healthcare system in western Washington state, 2005-2006.. American journal of hematology. 85(10):765-70. Abstract
Jusko, TA, De Roos AJ, Schwartz SM, Lawrence PB, Palkovicova L, Nemessanyi T, Drobna B, Fabisikova A, Kocan A, Sonneborn D et al..  2010.  A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age.. Environmental research. 110(4):388-95. Abstract
Wong, EY, Ray R, Gao DL, Wernli KJ, Li W, Fitzgibbons DE, Camp JE, Heagerty PJ, De Roos AJ, Holt VL et al..  2010.  Physical activity, physical exertion, and miscarriage risk in women textile workers in Shanghai, China.. American journal of industrial medicine. 53(5):497-505. Abstract
Hofmann, JN, Keifer MC, De Roos AJ, Fenske RA, Furlong CE, van Belle G, Checkoway H.  2010.  Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State.. Occupational and environmental medicine. 67(6):375-86. Abstract
Ross, ME, Wakefield J, Davis S, De Roos AJ.  2010.  Spatial clustering of myelodysplastic syndromes (MDS) in the Seattle-Puget Sound region of Washington State.. Cancer causes & control : CCC. 21(6):829-38. Abstract
De Roos, AJ, Davis S, Colt JS, Blair A, Airola M, Severson RK, Cozen W, Cerhan JR, Hartge P, Nuckols JR et al..  2010.  Residential proximity to industrial facilities and risk of non-Hodgkin lymphoma.. Environmental research. 110(1):70-8. Abstract
De Roos, AJ, Ulrich CM, Ray RM, Mossavar-Rahmani Y, Rosenberg CA, Caan BJ, Thomson CA, McTiernan A, LaCroix AZ.  2010.  Intentional weight loss and risk of lymphohematopoietic cancers.. Cancer causes & control : CCC. 21(2):223-36. Abstract
Gold, LS, Milliken K, Stewart P, Purdue M, Severson R, Seixas N, Blair A, Davis S, Hartge P, De Roos AJ.  2010.  Occupation and multiple myeloma: an occupation and industry analysis.. American journal of industrial medicine. 53(8):768-79. Abstract
Hofmann, JN, Keifer MC, Checkoway H, De Roos AJ, Farin FM, Fenske RA, Richter RJ, van Belle G, Furlong CE.  2010.  Biomarkers of sensitivity and exposure in washington state pesticide handlers.. Advances in experimental medicine and biology. 660:19-27. Abstract