Anneclaire J. De Roos

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Epidemiology
Associate Member, Appointed: 2008
University of Washington
School of Public Health and Community Medicine
Epidemiology
Associate Professor, Appointed: 2009
University of Washington
School of Public Health
Environmental and Occupational Health Sciences
Adjunct Associate Professor, Appointed: 2009
Professional Headshot of Anneclaire J. De Roos

Mailing Address

1100 Fairview Avenue N.
P.O. Box 19024
M4-B874
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-7315
Fax: (206) 667-4787
deroos@u.washington.edu

Degrees

Ph.D., University of North Carolina at Chapel Hill, Epidemiology, 2000.
M.P.H., University of California, Berkeley, Epidemiology/Biostatistics, 1995.
B.A., University of California, Los Angeles, Geography, 1990.

Research Interests

Dr. De Roos' research interests and experience are primarily in occupational and environmental exposures to chemicals and radiation as risk factors for cancer, other chronic diseases, and intermediate biologic effects. She has conducted studies of lymphomas, leukemias, autoimmune diseases, childhood cancers, and adult brain tumors.

A focus of Dr. De Roos' research is in health effects of exposure to persistent organic pollutants (POPs). In a study of POPs in plasma as contributors to non-Hodgkin lymphoma (NHL) risk (Cancer Res, 2005), Dr. De Roos and colleagues found that certain moderate- and highly-chlorinated polychlorinated biphenyl (PCB) congeners were associated with two- to three-fold increased risk of NHL (comparing extreme quartiles). The dioxin-like furan compounds measured were also strongly associated with NHL incidence, with a significant trend across quartiles (p=0.006), and the toxic equivalency quotient (TEQ), a summed metric that weights congeners by their dioxin-like potency, was associated with 35% increased risk of NHL per 10 TEQ units. These results suggest that exposures to POPs, particularly dioxin-like POPs and certain non-dioxin-like PCBs, contribute to NHL risk. Dr. De Roos is currently investigating how PCB concentrations change during weight loss in a group of women participating in an exercise intervention trial, and how PCBs may affect immune function in these women.

Dr. De Roos is investigating environmental and occupational exposures in relation to lymphohematopoietic cancers in the Women's Health Initiative (WHI) study, including insecticide exposures and farming history. A possible mechanism by which environmental exposures may contribute to NHL risk is by affecting the immune system, either through immune suppression or B-cell activation and proliferation. In a case-control study nested within the WHI Observational Study, Dr. De Roos is investigating viral and immune markers in prediagnostic biologic samples as predictors of incident NHL. Markers of interest are antibodies to Epstein-Barr virus (EBV) antigens, circulating EBV DNA, and cytokines and other molecules involved in B-lymphocyte response, including IL6, IL10, TNFα, sCD23, sCD27, sCD30, sCD44, and CXCL13.

Several of Dr. De Roos' studies are exploring the use of geographic information systems and geographically-referenced environmental surveillance data to estimate individual-level exposures. One project focuses on environmental exposure to industrial pollution in relation to NHL risk, using data on industry locations, reported emissions, and census data. In another study, Dr. De Roos and investigators at the University of British Columbia are characterizing the possible role of air pollution in the incidence and exacerbation of rheumatoid arthritis in the Vancouver metropolitan region.

Memberships

International Society for Environmental Epidemiology

Honors and Awards

2001-2001, Intramural Research Award, Division of Cancer Epidemiology and Genetics, National Cancer Institute
2000-2000, Delta Omega National Honor Society in Public Health, Delta Omega National Honor Society

Previous Positions

2003-2009, Assistant Professor, University of Washington, School of Public Health, Department of Epidemiology
2003-2008, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
2000-2002, Postdoctoral Fellow, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch
1990-1992, Environmental Scientist, AeroVironment, Inc.

Funding

  • National Institute of Health/National Heart, Lung and Blood Institute: Markers of B-Cell Stimulation as Potential Predictors of Non-Hodgkin Lymphoma, $728,796, 2009 to 2011.
  • National Institute of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases: Role of Air Pollution in Rheumatoid Arthritis Incidence and Exacerbation, $100,000, 2007 to 2009.
  • National Institute of Health/National Institute for Environmental Health Sciences: Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects, $100,000, 2007 to 2009.
  • Amgen, Inc/Global Epidemiology Division: Descriptive Epidemiology of Clinical Course of Myelodysplastic Syndromes (MDS) in a Health Maintenance Organization, $257,768, 2006 to 2008.
  • National Cancer Institute: Transdisciplinary Research in Energetics and Cancer: Energy Balance, Polychlorinated Biphenyl (PCB) Exposure and Possible Toxicologic Effects, $25,000, 2006 to 2007.
  • Fred Hutchinson Cancer Research Center, Hartwell Innovation Fund: Immunotoxicology of Persistent Organochlorine Pollutant Exposure from Weight Loss, $50,000, 2006 to 2007.
  • National Institute of Health/National Cancer Institute: Industrial Pollutants and Risk of Non-Hodgkin's Lymphoma, $100,000, 2005 to 2007.
  • National Cancer Institute/Surveillance, Epidemiology, and End Results (SEER): Descriptive Epidemiology of Clinical Course of Myelodysplastic Syndromes and Potential Space-Time Clustering in Incidence, $69,114, 2005 to 2006.
  • The Arthritis Foundation: Predictors of Work Disability in Rheumatoid Arthritis, $20,000, 1997 to 1999.

 

Recent Publications

2014
2013
Andreotti, G, Birmann B, De Roos AJ, Spinelli J, Cozen W, Camp NJ, Moysich K, Chiu B, Steplowski E, Krzystan J et al..  2013.  A pooled analysis of alcohol consumption and risk of multiple myeloma in the international multiple myeloma consortium.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(9):1620-7. Abstract
De Roos, AJ, Martinez-Maza O, Jerome KR, Mirick DK, Kopecky KJ, Madeleine MM, Magpantay L, Edlefsen KL, LaCroix AZ.  2013.  Investigation of Epstein-Barr Virus as a Potential Cause of B-Cell Non-Hodgkin Lymphoma in a Prospective Cohort.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
2012
2011