Stephen C. DeRosa

Appointments and Affiliations

 
 
University of Washington
School of Medicine
Laboratory Medicine
Virology
Research Assistant Professor
Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Division
Associate Member
Professional Headshot of Stephen C. De Rosa

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. North, E4-200
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-1681
sderosa@fhcrc.org

Degrees

M.D., Stanford University, School of Medicine, 1990.
B.S., Columbia University, Chemical Engineering, 1983.

Research Interests

My research focuses on the flow cytometric characterization of T cells induced by candidate T cell vaccines tested within the HIV Vaccine Trials Network (HVTN). We have developed assays that examine multiple T cell markers and functions simultaneously. An ultimate goal of this research is to identify the characteristic features of effective immune responses. This goal may not be achievable until larger phase II and III efficacy trials are performed, but in the interim, we use these assays to compare T cells induced by different vaccine regimens. Recent studies in our laboratory related to the failure of the vaccine tested in the Step trial have resulted in a broader examination of the potential impact of vaccination on the immune system. We are examining T cells that are specific for the vaccine vector. We are also developing methods to identify regulatory or suppressive T cells that can potentially be induced by vaccination.

Memberships

International Society for Analytical Cytology

Previous Positions

Assistant Professor, University of Washington, Virology

 

Recent Publications

2014
2013
2012
De Rosa, SC, Carter DK, McElrath MJ.  2012.  OMIP-014: Validated multifunctional characterization of antigen-specific human T cells by intracellular cytokine staining.. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 81(12):1019-21.
2011
2010
2009
2008