Ph.D., Carnegie Mellon University, Statistics, 1990.
M.S., Carnegie Mellon University, Statistics, 1987.
B.S., University of Cape Town, Statistics, 1985.
Methods for evaluating diagnostic tests
Modeling and outcomes research in prostate cancer
Modeling impact of PSA screening and other interventions on prostate cancer incidence and mortality
Costs and benefits of prostate cancer screening
Trends in prostate cancer screening and related behaviors
Dr. Ruth (Douglas) Etzioni is a Full Member in Biostatistics of the Division of Public Health Sciences at the Fred Hutchinson Cancer Research Center. Her work focuses on the development and implementation of statistical methods for prostate cancer studies. In the past, she has worked on assessing the efficacy of PSA screening from population studies, estimating the frequency of overdiagnosis associated with PSA, evaluating novel prostate cancer biomarkers, and tracking patterns and outcomes of prostate cancer care. Her work in prostate cancer surveillance is conducted as part of the Cancer Intervention and Surveillance Modeling Network (CISNET).
As leader of the biostatistics core for the Northwest Prostate Cancer SPORE, Dr. Etzioni has developed methods for analyzing immunohistochemical studies, and combining results from microarray experiments, while working with SPORE investigators to select the most appropriate design and analysis approaches for a broad array of studies. She is an affiliate investigator on the Data Management Coordination Center for the Early Detection Research Network (EDRN) and continues to work with EDRN statisticians on methods for biomarker development. In addition to these projects, her current interests include modeling the development of resistance to androgen ablation therapy.
American Statistical Association
Institute of Mathematical Statistics
International Biometric Society
Society for Medical Decision Making
Economic Return From the Women's Health Initiative Estrogen Plus Progestin Clinical Trial: A Modeling Study.. Annals of internal medicine. 160(9):594-602.. 2014.
Oversimplifying Overdiagnosis.. Journal of general internal medicine.. 2014.
RE: A Model Too Far.. Journal of the National Cancer Institute.. 2014.
Comparison of Survival Outcomes Among Cancer Patients Treated In and Out of Clinical Trials.. Journal of the National Cancer Institute.. 2014.
Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms and benefits.. Annals of internal medicine. 161(2):104-12.. 2014.
Overdiagnosis and Overtreatment of Prostate Cancer.. European urology.. 2014.
Is prostate cancer screening cost-effective? A microsimulation model of prostate-specific antigen-based screening for British Columbia, Canada. International journal of cancer. Journal international du cancer.. 2014.
Individualized estimates of overdiagnosis in screen-detected prostate cancer.. Journal of the National Cancer Institute. 106(2):djt367.. 2014.
Biological correlates of biochemical recurrence free survival using multiple markers in a large tissue microarray cohort.. Annals of clinical and laboratory science. 43(1):11-21.. 2013.
Advanced diagnostic breast cancer imaging: variation and patterns of care in washington state.. Journal of oncology practice / American Society of Clinical Oncology. 9(5):e194-202.. 2013.
Modeling grade progression in an active surveillance study.. Statistics in medicine.. 2013.
Early Detection of Prostate Cancer: AUA Guideline.. The Journal of urology.. 2013.
Alternative prostate cancer screening strategies--in response.. Annals of internal medicine. 158(10):778-9.. 2013.
American Cancer Society lung cancer screening guidelines.. CA: a cancer journal for clinicians. 63(2):106-17.. 2013.
Influence of study features and methods on overdiagnosis estimates in breast and prostate cancer screening.. Annals of internal medicine. 158(11):831-8.. 2013.
Comparative effectiveness of alternative prostate-specific antigen-based prostate cancer screening strategies: model estimates of potential benefits and harms.. Annals of internal medicine. 158(3):145-53.. 2013.
Effects of Screening on Radical Prostatectomy Efficacy: The Prostate Cancer Intervention Versus Observation Trial.. Journal of the National Cancer Institute.. 2013.
Response: Reading between the lines of cancer screening trials: using modeling to understand the evidence.. Medical care. 51(4):304-6.. 2013.
Evaluation of new technologies for cancer control based on population trends in disease incidence and mortality.. Journal of the National Cancer Institute. Monographs. 2013(46):117-23.. 2013.
Building better models: if we build them, will policy makers use them? Toward integrating modeling into health care decisions. Medical decision making : an international journal of the Society for Medical Decision Making. 32(5):656-9.. 2012.
Prostate Cancer Mortality following Active Surveillance versus Immediate Radical Prostatectomy.. Clinical cancer research : an official journal of the American Association for Cancer Research. 18(19):5471-5478.. 2012.