Ziding Feng

Appointments and Affiliations
 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Cancer Prevention and Biostatistics
Full Member, Appointed: 2001
University of Washington
School of Public Health and Community Medicine
Biostatistics
Affiliate Full Professor, Appointed: 2003
 Professional Headshot of Ziding Feng

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North, M2-B500
P.O. Box 19024
Seattle, Washington 98109
United States

Contact

Phone: (206) 667-6038
Fax: (206) 667-5977
zfeng@fhcrc.org

Degrees

Ph.D., Cornell University, Biometry, 1990.

Research Interests

My statistical methods research, in conjunction with colleagues and students, aims to improve the design and analysis of disease prevention trials, and observational studies. One emphasis has been the development of efficient design and analysis strategies for group randomized trials. Recent efforts include the proposal of a weighted permutation inference and a global test for multiple endpoints. Another emphasis has been the development of methods for cancer biomarker studies. Recent efforts include the development of guidelines for biomarker evaluation in cancer early detection, analysis methods for high dimensional data such as protein expression data from mass spectrometry, and Finite Mixture Models.

My applied research, in conjunction with colleagues and staff members, include the coordination of the national Early Detection Research Network (EDRN). This network includes 31 institutions in US with the mission to identify and validate biomarkers for early detection of cancer. We at FHCRC provide logistic, bioinformatics, and data management support for EDRN, and develop statistical methodology useful for EDRN mission.

I also collaborate with a large number of colleagues on variety of research projects including prostate cancer epidemiology and outcome, GI cancer etiology and biomarkers, community intervention trials, and occupational epidemiology.

Languages

(Reading, Writing, Speaking)

Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

American Statistical Association
Biometric Society

Honors and Awards

1990, Cornell Graduate School Fellowship,
1988-1989, Cornell Outstanding Teaching Assistant Award,
1984, Cornell Graduate School Liu Memorial Award,

Previous Positions

1997-2003, Affiliate Associate Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1996-2001, Associate Member, Fred Hutchinson Cancer Research Center, Cancer Prevention Research
1990-1997, Affiliate Assistant Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1990-1996, Assistant Member, Fred Hutchinson Cancer Research Center, Cancer Prevention Research

Funding

  • National Institutes of Health (NIH)/National Cancer Institute (NCI): Early Detection Research Network: Data Management and Coordinating Center, 2001 to 2010.
  • National Institutes of Health (NIH): Statistical Methods for Medical Studies (Project 3 Leader, PI Ross Prentice), 2001 to 2011.
  • National Institutes of Health (NIH)/National Cancer Institute (NCI): Statistical Methods for Community Intervention Trials, 2000 to 2006.
  • National Institutes of Health (NIH)/National Cancer Institute (NCI): Cancer Prevention Research Program, 1995 to 2001.

 

Recent Publications

2013
Lin, DW, Newcomb LF, Brown EC, Brooks JD, Carroll PR, Feng Z, Gleave ME, Lance RS, Sanda MG, Thompson IM et al..  2013.  Urinary TMPRSS2:ERG and PCA3 in an Active Surveillance Cohort: Results from a Baseline Analysis in the Canary Prostate Active Surveillance Study.. Clinical cancer research : an official journal of the American Association for Cancer Research. 19(9):2442-2450. Abstract
Ma, GX, Gao W, Fang CY, Tan Y, Feng Z, Ge S, Nguyen JA.  2013.  Health beliefs associated with cervical cancer screening among vietnamese americans.. Journal of women's health (2002). 22(3):276-88. Abstract
Ankerst, DP, Till C, Boeck A, Goodman P, Tangen CM, Feng Z, Partin AW, Chan DW, Sokoll L, Kagan J et al..  2013.  The impact of prostate volume, number of biopsy cores, and AUA symptom score on the sensitivity of cancer detection using the Prostate Cancer Prevention Trial Risk Calculator.. The Journal of urology. Abstract
Holt, SK, Kwon EM, Fu R, Kolb S, Feng Z, Ostrander EA, Stanford JL.  2013.  Association of variants in estrogen-related pathway genes with prostate cancer risk.. The Prostate. 73(12):1-10. Abstract
Feng, Z, Kagan J, Pepe M, Thornquist M, Ann Rinaudo J, Dahlgren J, Krueger K, Zheng Y, Patriotis C, Huang Y et al..  2013.  The Early Detection Research Network's Specimen Reference Sets: Paving the Way for Rapid Evaluation of Potential Biomarkers.. Clinical chemistry. 59(1):68-74. Abstract
Hawley, S, Fazli L, McKenney JK, Simko J, Troyer D, Nicolas M, Newcomb LF, Cowan JE, Crouch L, Ferrari M et al..  2013.  A model for the design and construction of a resource for the validation of prognostic prostate cancer biomarkers: the Canary Prostate Cancer Tissue Microarray.. Advances in anatomic pathology. 20(1):39-44. Abstract
Chao, T, Ladd JJ, Qiu J, Johnson MM, Israel R, Chin A, Wang H, Prentice RL, Feng Z, Disis ML et al..  2013.  Proteomic profiling of the autoimmune response to breast cancer antigens uncovers a suppressive effect of hormone therapy.. Proteomics. Clinical applications. Abstract
Geybels, MS, Wright JL, Holt SK, Kolb S, Feng Z, Stanford JL.  2013.  Statin Use in Relation to Prostate Cancer Outcomes in a Population-based Patient Cohort Study.. The Prostate. Abstract
Anderson, CAM, Beresford SAA, McLerran D, Lampe JW, Deeb S, Feng Z, Motulsky AG.  2013.  Response of serum and red blood cell folate concentrations to folic acid supplementation depends on methylenetetrahydrofolate reductase C677T genotype: results from a crossover trial.. Molecular nutrition & food research. 57(4):637-44. Abstract
2012
Lin, Y, Fu R, Grant E, Chen Y, Lee JE, Gupta PC, Ramadas K, Inoue M, Tsugane S, Gao Y-T et al..  2012.  Association of body mass index and risk of death from pancreas cancer in Asians: findings from the Asia Cohort Consortium.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). Abstract
Geybels, MS, Hutter CM, Kwon EM, Ostrander EA, Fu R, Feng Z, Stanford JL, Peters U.  2012.  Variation in selenoenzyme genes and prostate cancer risk and survival.. The Prostate. Abstract
Hazelton, WD, Goodman G, Rom WN, Tockman M, Thornquist M, Moolgavkar S, Weissfeld JL, Feng Z.  2012.  Longitudinal multistage model for lung cancer incidence, mortality, and CT detected indolent and aggressive cancers.. Mathematical biosciences. 240(1):20-34. Abstract
Liang, Y, Ankerst DP, Feng Z, Fu R, Stanford JL, Thompson IM.  2012.  The risk of biopsy-detectable prostate cancer using the prostate cancer prevention Trial Risk Calculator in a community setting.. Urologic oncology. Abstract
Zheng, Y, Cai T, Jin Y, Feng Z.  2012.  Evaluating Prognostic Accuracy of Biomarkers under Competing Risk.. Biometrics. 68(2):388-396. Abstract
Lu, H, Ladd J, Feng Z, Wu M, Goodell V, Pitteri SJ, Li CI, Prentice R, Hanash SM, Disis ML.  2012.  Evaluation of Known Oncoantibodies, HER2, p53, and Cyclin B1, in Prediagnostic Breast Cancer Sera.. Cancer prevention research (Philadelphia, Pa.). Abstract
Randolph, TW, Harezlak J, Feng Z.  2012.  Structured penalties for functional linear models-partially empirical eigenvectors for regression.. Electronic journal of statistics. 6:323-353. Abstract
Ankerst, DP, Koniarski T, Liang Y, Leach RJ, Feng Z, Sanda MG, Partin AW, Chan DW, Kagan J, Sokoll L et al..  2012.  Updating risk prediction tools: A case study in prostate cancer.. Biometrical journal. Biometrische Zeitschrift. 54(1):127-142. Abstract
Koopmeiners, JS, Feng Z, Pepe MS.  2012.  Conditional estimation after a two-stage diagnostic biomarker study that allows early termination for futility.. Statistics in medicine. 31(5):420-435. Abstract
Shang, S, Plymoth A, Ge S, Feng Z, Rosen HR, Sangrajrang S, Hainaut P, Marrero JA, Beretta L.  2012.  Identification of osteopontin as a novel marker for early hepatocellular carcinoma.. Hepatology (Baltimore, Md.). 55(2):483-90. Abstract
Shang, S, Plymoth A, Ge S, Feng Z, Rosen HR, Sangrajrang S, Hainaut P, Marrero JA, Beretta L.  2012.  Identification of osteopontin as a novel marker for early hepatocellular carcinoma.. Hepatology (Baltimore, Md.). 55(2):483-90. Abstract
Pepe, MS, Fan J, Seymour CW, Li C, Huang Y, Feng Z.  2012.  Biases introduced by choosing controls to match risk factors of cases in biomarker research.. Clinical chemistry. 58(8):1242-51. Abstract
Ladd, J, Busald Buson T, Johnson M, Zhang Q, Pitteri SJ, Wang H, Brenner DE, Lampe PD, Kucherlapati RS, Feng Z et al..  2012.  Increased plasma levels of the APC-interacting protein MAPRE1, LRG1 and IGFBP2 preceding a diagnosis of colorectal cancer in women.. Cancer prevention research (Philadelphia, Pa.). 5(4):655-664. Abstract
Elashoff, D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A et al..  2012.  Prevalidation of Salivary Biomarkers for Oral Cancer Detection.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(4):664-672. Abstract
Ma, GX, Fang CY, Feng Z, Tan Y, Gao W, Ge S, Nguyen C.  2012.  Correlates of Cervical Cancer Screening among Vietnamese American Women.. Infectious diseases in obstetrics and gynecology. 2012:617234. Abstract
Thu, KL, Vucic EA, Chari R, Zhang W, Lockwood WW, English JC, Fu R, Wang P, Feng Z, MacAulay CE et al..  2012.  Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.. PloS one. 7(3):e33003. Abstract