David Fredricks

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
Vaccine and Infectious Diseases Division
Program in Infectious Diseases
Full Member, Appointed: 2012
University of Washington
School of Medicine, Allergy and Infectious Diseases
Professor, Appointed: 2013
 
University of Washington
Adjunct Associate Professor, Microbiology
 
University of Washington
Director, Infectious Diseases Fellowship Training Program
Professional Headshot of David  Fredricks

Mailing Address

Fred Hutchinson Cancer Research Center
P.O. Box 19024
Vaccine and Infectious Disease Division
E4-100
Seattle, Washington 98109-1024
United States

Degrees

M.D., Case Western Reserve University, Medicine, 1990.

Research Interests

The Fredicks laboratory develops and applies molecular diagnostic tests for the detection and identification of microbial pathogens, including those pathogens that are difficult to culture in the laboratory. We employ the polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) to detect and localize bacteria and fungi in human tissues. These molecular approaches are applied to improve the detection of well known pathogens, and to investigate the role of novel or uncultivated microbes in unexplained human diseases (pathogen discovery). The laboratory has developed a suite of PCR assays for the detection of fungal pathogens in immunocompromised patients.

We also study the constituents of the human indigenous microbiota, using cultivation-independent approaches to characterize microbes present on human mucosal and epithelial surfaces. The microbiology of the human vagina is an area of research focus, and we are particularly interested in the role of fastidious bacteria in the syndrome bacterial vaginosis. We also study the role of fastidious vaginal bacteria in other adverse health conditions in women.

Additional Experience

Previous research has been performed on the cultivation-resistant pathogens Tropheryma whipplei (bacterial cause of Whipple Disease) and Rhinosporidium seeberi (protistan parasite that causes nasal and ocular tumors in rhinosporidiosis).

Memberships

American Association for the Advancement of Science
American Society for Microbiology
Infectious Diseases Society of America

Honors and Awards

Physician Scientist Award, National Institutes of Health, Stanford University
Program Commitee Choice Award, Infectious Diseases Society of America, Best abstract at 2004 annual meeting, Boston.
James McDougall Faculty Mentor Award, Fred Hutchinson Cancer Research Center

Previous Positions

2007-2013, Associate Professor, University of Washington, School of Medicine, Allergy, and Infectious Diseases
2007-2012, Associate Member, Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division & Clinical Research Division
2001-2007, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Program in Infectious Diseases
2001-2007, Assistant Professor, University of Washington, School of Medicine, Medicine, Allergy and Infectious Diseases
1998-2001, Research Associate, Stanford University, School of Medicine, Medicine, Infectious Diseases

Funding

  • National Institutes of Health (NIH): R01, The role of uncultivated bacteria in bacterial vaginosis, 2006 to .
  • National Institutes of Health (NIH): R01, Quantitative PCR for the detection of fungal infections, 2004 to .

 

Recent Publications

2014
2013
2012
Rickerts, V, Khot PD, Ko DL, Fredricks DN.  2012.  Enhanced fungal DNA-extraction from formalin-fixed, paraffin-embedded tissue specimens by application of thermal energy.. Medical mycology : official publication of the International Society for Human and Animal Mycology. 50(6):667-72. Abstract
2011
2010
2009