Philip D. Greenberg

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research
 
University of Washington
School of Medicine
Immunology
Professor, Appointed: 1988
University of Washington
School of Medicine
Medicine
Oncology
Professor, Appointed: 1988
Professional Headshot of Philip D. Greenberg

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N.
P.O. Box 19024
D3-100
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 543-8306
Fax: (206) 685-3128
pgreen@u.washington.edu
http://labs.fhcrc.org/pgreenberg/index.html
 

Degrees

M.D. (Summa Cum Laude), University of California, San Diego, 1971.
Degree, University of California, San Diego, Biology.
Postdoctoral Training, University of California, San Diego.

Research Interests

Tumor and viral immunobiology

The overall goals of the laboratory are to elucidate principles underlying T cell recognition of viruses and cancer cells, determine why such responses often fail to eliminate the viral pathogen or cancer, and develop cellular and molecular approaches to manipulate cellular immunity to treat human viral and malignant diseases. Several ongoing projects are:

1. Immunobiology of malignancies.
Studies in transgenic mice are examining the requirements for inducing T cell responses to self-proteins over-expressed in tumors. The molecular basis for non-responsiveness to such potential therapeutic targets is being evaluated by studying gene expression in homogenous populations of tolerant transgenic T cells both biochemically and with microarrays, and strategies for rescuing function in such T cells are being investigated. Differential gene expression in human tumors is also being assessed to identify candidate human tumor antigens, and T cells reactive to such antigens are being generated and analyzed for the ability to selectively recognize malignant and not normal tissues. Clinical trials are currently being developed for the treatment of human leukemias by adoptive transfer of T cell clones previously expandedto large numbers in vitro that are specific for already identified over-expressed oncogenic proteins.

2. Genetic modification of T cells.
Many obstacles to generating or maintaining an effective T cell response to infections and tumors are being identified. Genetic modification of T cells via retroviral shuttle vectors provides a means to impart new functions or disrupt interfering or regulatory pathways, and expression in T cells of molecules such as chimeric receptors, homing receptors, signaling molecules, dominant-negative proteins, and siRNAs is being studied both in vitro and in vivo in murine models.

3. Immunobiology of HIV.
Studies are evaluating strategies to develop protective vaccine in a primate model, employing a hybrid SIV/HIV virus. A trial is being developed in which autologous SHIV-specific CD8+ T cell clones expanded in vitro are being administered with or without monoclonal neutralizing antibodies to uninfected macaques to determine the immunologic requirements for protection from infection and to define standards for the nature and magnitude of immune responses that must be achieved by vaccination strategies. Cellular and molecular assays are being used to monitor the persistence, function, and in vivo homing of these transferred T cells.

Additional Experience

Joined the Fred Hutchinson Cancer Research Center and the Division of Oncology at the University of Washington in 1976

Since 1988 he has also served as the Director of the Immunology Program of the UW Center for AIDS Research.

 

Memberships

Alpha Omega Alpha

Previous Positions

1989, Professor, University of Washington,
1988, Professor, University of Washington,
1988, Director, University of Washington, Center for AIDS Research, Immunology
1983-1988, Adjunct Associate Professor, University of Washington
1991-present, Fred Hutchinson Cancer Research Center, Immunology, Head
1982-1988, University of Washington, Associate Professor

 

Recent Publications

2014
2013
2012
2011
Greenberg, PD.  2011.  Ralph M. Steinman: A man, a microscope, a cell, and so much more.. Proceedings of the National Academy of Sciences of the United States of America. 108(52):20871-2.
2010