Katherine A. Guthrie
Ph.D., University of Washington, Biostatistics, 2001.
M.S., University of Washington, Biostatistics, 1997.
B.S., Bates College, Mathematics, 1989.
The majority of my research involves collaborative projects with investigators of the Clinical Research Division. These projects include the design and analysis of Phase I, II, and III clinical trials, which aim to expand and improve our ability to treat patients with a wide range of diseases and prognoses. In addition, I carry out a variety of retrospective analyses that make use of the large volume of data generated from past transplants. These studies help to generate hypotheses for future prospective studies, as well as allow us to monitor progress made in the field.
Additional interests include studies of the health effects of microchimerism with J. Lee Nelson's lab, where microchimerism refers to small numbers of cells that traffic from a mother into the fetus and from the fetus into the mother during pregnancy and which may persist in their respective hosts decades later. I am a collaborator in studies related to autoimmune diseases, cancer and pregnancy outcomes.
American Statistical Association
International Biometric Society
Honors and Awards
Phi Beta Kappa, 1989, Bates College
Outstanding Student Award, Department of Biostatistics, 2000, University of Washington
Self Collection of Foam Nasal Swabs for Respiratory Virus Detection by PCR among Immunocompetent Subjects and Hematopoietic Cell Transplant Recipients.. Journal of clinical microbiology. 51(1):324-327.. 2013.
Design and methods of a multi-site, multi-behavioral treatment trial for menopausal symptoms: The MsFLASH experience.. Contemporary clinical trials. 35(1):25-34.. 2013.
WU and KI Polyomaviruses in Respiratory Samples from Allogeneic Hematopoietic Cell Transplant Recipients.. Emerging infectious diseases. 18(10):1580-8.. 2012.
Sexual function in nondepressed women using escitalopram for vasomotor symptoms: a randomized controlled trial.. Obstetrics and gynecology. 119(3):527-38.. 2012.
Effect of escitalopram on hot flash interference: a randomized, controlled trial.. Fertility and sterility. 97(6):1399-1404.e1.. 2012.
Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer.. Molecular and cellular biology. 32(11):2160-7.. 2012.
Keratinocyte Dysplasia in Hematopoietic Stem Cell Transplantation Recipients in the Day-28-to-84 Posttransplantation Period.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2012.
Male microchimerism in the human female brain.. PloS one. 7(9):e45592.. 2012.
Soluble donor DNA and islet injury after transplantation.. Transplantation. 92(5):607-11.. 2011.
Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism.. Arthritis and rheumatism. 63(3):640-4.. 2011.
Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(3):341-50.. 2011.
Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial.. JAMA : the journal of the American Medical Association. 305(3):267-74.. 2011.
Mantle cell lymphoma international prognostic index but not pretransplantation induction regimen predicts survival for patients with mantle-cell lymphoma receiving high-dose therapy and autologous stem-cell transplantation.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 29(22):3023-9.. 2011.
Parity and HLA alleles in risk of rheumatoid arthritis.. Chimerism (Print). 2(1):11-15.. 2011.
Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host? Blood. 116(15):2706-12.. 2010.
Respiratory virus pneumonia after hematopoietic cell transplantation (HCT): associations between viral load in bronchoalveolar lavage samples, viral RNA detection in serum samples, and clinical outcomes of HCT.. The Journal of infectious diseases. 201(9):1404-13.. 2010.
Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis and rheumatism. 62(7):1842-8.. 2010.
The impact of a change in antibacterial prophylaxis from ceftazidime to levofloxacin in allogeneic hematopoietic cell transplantation.. Bone marrow transplantation. 45(4):675-81.. 2010.