Katherine A. Guthrie

Appointments and Affiliations
 
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
Clinical Statistics
Associate Member, Appointed: 2008
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics
Associate Member, Appointed: 2008
 Professional Headshot of Katherine A. Guthrie

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
P.O. Box 19024
D5-360
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-5595
Fax: (206) 667-6358
kguthrie@fhcrc.org

Degrees

Ph.D., University of Washington, Biostatistics, 2001.
M.S., University of Washington, Biostatistics, 1997.
B.S., Bates College, Mathematics, 1989.

Research Interests

The majority of my research involves collaborative projects with investigators of the Clinical Research Division. These projects include the design and analysis of Phase I, II, and III clinical trials, which aim to expand and improve our ability to treat patients with a wide range of diseases and prognoses. In addition, I carry out a variety of retrospective analyses that make use of the large volume of data generated from past transplants. These studies help to generate hypotheses for future prospective studies, as well as allow us to monitor progress made in the field.

Additional interests include studies of the health effects of microchimerism with J. Lee Nelson's lab, where microchimerism refers to small numbers of cells that traffic from a mother into the fetus and from the fetus into the mother during pregnancy and which may persist in their respective hosts decades later. I am a collaborator in studies related to autoimmune diseases, cancer and pregnancy outcomes.

Memberships

American Statistical Association
International Biometric Society

Honors and Awards

Phi Beta Kappa, 1989, Bates College
Outstanding Student Award, Department of Biostatistics, 2000, University of Washington

Recent Publications

2013
Joffe, H, Guthrie KA, Larson J, Cohen LS, Carpenter JS, LaCroix AZ, Freeman EW.  2013.  Relapse of vasomotor symptoms after discontinuation of the selective serotonin reuptake inhibitor escitalopram: results from the menopause strategies: finding lasting answers for symptoms and health research network.. Menopause (New York, N.Y.). 20(3):261-8. Abstract
Campbell, AP, Kuypers J, Englund JA, Guthrie KA, Corey L, Boeckh MJ.  2013.  Self Collection of Foam Nasal Swabs for Respiratory Virus Detection by PCR among Immunocompetent Subjects and Hematopoietic Cell Transplant Recipients.. Journal of clinical microbiology. 51(1):324-327. Abstract
Sternfeld, B, Lacroix A, Caan BJ, Dunn AL, Newton KM, Reed SD, Guthrie KA, Booth-Laforce C, Sherman KJ, Cohen L et al..  2013.  Design and methods of a multi-site, multi-behavioral treatment trial for menopausal symptoms: The MsFLASH experience.. Contemporary clinical trials. 35(1):25-34. Abstract
2012
Joffe, H, Guthrie KA, Larson J, Cohen LS, Carpenter JS, LaCroix AZ, Freeman EW.  2012.  Relapse of vasomotor symptoms after discontinuation of the selective serotonin reuptake inhibitor escitalopram: results from the Menopause Strategies: Finding Lasting Answers for Symptoms and Health Research Network.. Menopause (New York, N.Y.). Abstract
Kuypers, J, Campbell AP, Guthrie KA, Wright NL, Englund JA, Corey L, Boeckh MJ.  2012.  WU and KI Polyomaviruses in Respiratory Samples from Allogeneic Hematopoietic Cell Transplant Recipients.. Emerging infectious diseases. 18(10):1580-8. Abstract
Ensrud, KE, Joffe H, Guthrie KA, Larson JC, Reed SD, Newton KM, Sternfeld B, LaCroix AZ, Landis CA, Woods NF et al..  2012.  Effect of escitalopram on insomnia symptoms and subjective sleep quality in healthy perimenopausal and postmenopausal women with hot flashes: a randomized controlled trial.. Menopause (New York, N.Y.). Abstract
Reed, SD, Guthrie KA, Joffe H, Shifren JL, Seguin RA, Freeman EW.  2012.  Sexual function in nondepressed women using escitalopram for vasomotor symptoms: a randomized controlled trial.. Obstetrics and gynecology. 119(3):527-38. Abstract
Carpenter, JS, Guthrie KA, Larson JC, Freeman EW, Joffe H, Reed SD, Ensrud KE, LaCroix AZ.  2012.  Effect of escitalopram on hot flash interference: a randomized, controlled trial.. Fertility and sterility. 97(6):1399-1404.e1. Abstract
Grim, JE, Knoblaugh SE, Guthrie KA, Hagar A, Swanger J, Hespelt J, Delrow JJ, Small T, Grady WM, Nakayama KI et al..  2012.  Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer.. Molecular and cellular biology. 32(11):2160-7. Abstract
Li, N, Guthrie KA, Storer BE, Martin PJ, Sale GE, Argenyi ZB, Myerson D.  2012.  Keratinocyte Dysplasia in Hematopoietic Stem Cell Transplantation Recipients in the Day-28-to-84 Posttransplantation Period.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. Abstract
Blake, JM, Nicoud IB, Weber D, Voorhies H, Guthrie KA, Heimfeld S, Delaney C.  2012.  Improved immunomagnetic enrichment of CD34 (+) cells from umbilical cord blood using the CliniMACS cell separation system.. Cytotherapy. 14(7):818-822. Abstract
Chan, WFN, Gurnot C, Montine TJ, Sonnen JA, Guthrie KA, Nelson JL.  2012.  Male microchimerism in the human female brain.. PloS one. 7(9):e45592. Abstract
2011
Gadi, VK, Nelson JL, Guthrie KA, Anderson CC, Boespflug ND, Redinger JW, Paul B, Dinyari P, Shapiro JAM.  2011.  Soluble donor DNA and islet injury after transplantation.. Transplantation. 92(5):607-11. Abstract
Yan, Z, Aydelotte T, Gadi VK, Guthrie KA, Nelson JL.  2011.  Acquisition of the rheumatoid arthritis HLA shared epitope through microchimerism.. Arthritis and rheumatism. 63(3):640-4. Abstract
Nemecek, ER, Guthrie KA, Sorror ML, Wood BL, Doney K, Hilger RA, Scott BL, Kovacsovics TJ, Maziarz RT, Woolfrey AE et al..  2011.  Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic cell transplantation for high-risk hematologic malignancies.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(3):341-50. Abstract
Gopal, AK, Guthrie KA, Rajendran J, Pagel JM, Oliveira G, Maloney DG, Matesan MC, Storb R, Press OW.  2011.  90Y-Ibritumomab tiuxetan, fludarabine, and TBI-based nonmyeloablative allogeneic transplantation conditioning for patients with persistent high-risk B-cell lymphoma.. Blood. 118(4):1132-9. Abstract
Freeman, EW, Guthrie KA, Caan B, Sternfeld B, Cohen LS, Joffe H, Carpenter JS, Anderson GL, Larson JC, Ensrud KE et al..  2011.  Efficacy of escitalopram for hot flashes in healthy menopausal women: a randomized controlled trial.. JAMA : the journal of the American Medical Association. 305(3):267-74. Abstract
Budde, LE, Guthrie KA, Till BG, Press OW, Chauncey TR, Pagel JM, Petersdorf SH, Bensinger WI, Holmberg L, Shustov AR et al..  2011.  Mantle cell lymphoma international prognostic index but not pretransplantation induction regimen predicts survival for patients with mantle-cell lymphoma receiving high-dose therapy and autologous stem-cell transplantation.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 29(22):3023-9. Abstract
Guthrie, KA, Gammill HS, Madeleine MM, Dugowson CE, Nelson JL.  2011.  Parity and HLA alleles in risk of rheumatoid arthritis.. Chimerism (Print). 2(1):11-15. Abstract
2010
Gammill, HS, Guthrie KA, Aydelotte TM, Waldorf KAM, Nelson JL.  2010.  Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host? Blood. 116(15):2706-12. Abstract
Campbell, AP, Chien JW, Kuypers J, Englund JA, Wald A, Guthrie KA, Corey L, Boeckh MJ.  2010.  Respiratory virus pneumonia after hematopoietic cell transplantation (HCT): associations between viral load in bronchoalveolar lavage samples, viral RNA detection in serum samples, and clinical outcomes of HCT.. The Journal of infectious diseases. 201(9):1404-13. Abstract
Milano, F, Campbell AP, Guthrie KA, Kuypers J, Englund JA, Corey L, Boeckh MJ.  2010.  Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients.. Blood. 115(10):2088-94. Abstract
Guthrie, KA, Dugowson CE, Voigt LF, Koepsell TD, Nelson JL.  2010.  Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis and rheumatism. 62(7):1842-8. Abstract
Guthrie, KA, Yong M, Frieze D, Corey L, Fredricks DN.  2010.  The impact of a change in antibacterial prophylaxis from ceftazidime to levofloxacin in allogeneic hematopoietic cell transplantation.. Bone marrow transplantation. 45(4):675-81. Abstract
2009
Oehler, VG, Guthrie KA, Cummings CL, Sabo K, Wood BL, Gooley TA, Yang T, Epping MT, Shou Y, Pogosova-Agadjanyan E et al..  2009.  The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells.. Blood. 114(15):3299-308. Abstract