Ph.D., Massachusetts Institute of Technology, 1964.
My interests have increasingly turned to how we can use the enormous knowledge that has accumulated over the last 50 years in genetics and biochemistry to benefit cancer patients. I believe the most efficient path is to improve molecular diagnostics to identify individuals at high risk for disease, detect cancer and other disease at an early stage when they can be cured, provide prognostic information and monitor therapeutic response. Over the last 10 years we have experienced advances in nucleic acid diagnostics that provide answers for some of these questions and demonstrate the potential for additional insights. However, proteins will likely provide deeper diagnostic information because of their greater diversity and because their state reflects biological function. The technology for protein diagnostics, however, is in its infancy. My efforts are directed toward improving the field of protein diagnostics. To do so, I am involved in national and international projects to increase the number of laboratories working in the area, develop more team science, improve the availability of informatics for data sharing, provide standardized reagents, and stimulate new technology development.
1997-2010, President and director, Fred Hutchinson Cancer Research Center, Human Biology Division, Director's Office
1973-2010, Professor, University of Washington, College of Arts and Sciences, Genetics