Sunil R. Hingorani

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
Publich Health Sciences Division
Associate Member, Appointed: 2010
University of Washington
School of Medicine
Department of Medicine
Associate Professor, Appointed: 2011
Professional Headshot of Sunil R. Hingorani

Mailing Address

1100 Fairview Avenue North
Mailstop: M5-C800
Seattle, Washington 98109
United States

Contact

Phone: (206) 667-6921
Fax: (206) 667-7576
srh@fhcrc.org

Degrees

M.D., Yale University, Medicine, 1994.
Ph.D., Yale University, Cellular & Molecular Physiology, 1994.
B.S., Yale University, Molecular Biophysics & Biochemistry, 1985.

Research Interests

PDA is a nearly uniformly lethal disease that defies all forms of conventional chemotherapy and radiotherapy. The same factors that conspire to obscure the diagnosis of the disease in patients until very advanced stages also hinder the study of its pathogenesis. Our laboratory has worked to develop animal models that faithfully mimic the clinical and histopathologic progression of human pancreatic ductal adenocarcinoma (PDA) from its earliest precursor lesions to invasive and metastatic disease. The murine models form the basis for our efforts to elucidate mechanisms of disease pathogenesis, to identify biomarkers associated with each stage of disease and, potentially, with disease response to specific therapies; and to develop and test strategies for chemoprevention and treatment. Our investigations have also helped identify unique genetic routes to PDA with distinct clinical and histopathologic features. Thus, the models should also provide more rigorous platforms for preclinical studies of disease-specific detection and treatment strategies that will be more predictive of efficacy in patients.

Memberships

American Association for Cancer Research

Honors and Awards

2007, Scientific Director, Michael Rolfe Pancreatic Cancer Foundation
2005, Laurence A. Mack Career Development Award in Pancreatic Cancer Research, American Association for Cancer Research/PanCAN Foundation
2004, Scholar in Training Award, American Association for Cancer Research
1988-1993, Howard Hughes Pre-Doctoral Fellowship Award, Howard Huges Foundation
1985, Summa cum laude, Yale University
1983, Phi Beta Kappa Honor Society, Phi Beta Kappa Honor Society

Previous Positions

2006-2011, Assistant Professor, Department of Medicine, University of Washington School of Medicine, Seattle, WA
2005-2010, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research, Public Health Sciences
2003-2005, Attending Physician, Philadelphia Veterans' Administration Medical Center, Hematology/Oncology
2002-2005, Instructor, University of Pennsylvania, Abramson Cancer Center and Abramson Family Cancer Research Institute, Medicine and Cancer Biology
1999-2000, Post-Doctoral Research Fellow, Massachusetts Institute of Technology
1997-2000, Clinical Fellow, Brigham and Women's Hospital, Internal Medicine
1997-2000, Clinical Fellow, Dana-Farber/Partners Cancer Care Program, Hematology and Oncology
1994-1997, Intern, Brigham and Women's Hospital, Department of Internal Medicine

 

Recent Publications

2014
2013
2012
2010
2009
2008