David M. Hockenbery

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Gastroenterolgy/Hepatology
Clinical Research
Member, Clinical Research Division, Appointed: 2004
Fred Hutchinson Cancer Research Center
Gastroenerology
Clinical Research Divison
Head, Appointed: 2010
University of Washington
School of Medicine
Medicine
Gastroenterology
Professor, Appointed: 2005
Fred Hutchinson Cancer Research Center
Basic Sciences Division
Human Biology
Member, Appointed: 2004
Professional Headshot of David M. Hockenbery

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N.
P.O. Box 19024
D2-190
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-4611
Fax: (206) 667-6519
http://labs.fhcrc.org/hockenbery/index.html

Degrees

M.D., Washington University, 1982.
B.S., University of Rochester, 1978.

Research Interests

Members of Dr. Hockenbery's laboratory study the genetic and biochemical mechanisms of programmed cell death, or apoptosis, in a variety of experimental systems. Normal cell death occurring during development and following terminal differentiation has typical morphologic and biochemical features collectively termed apoptosis. The precise control of these events is obviously of great importance to the organism and many model systems have demonstrated the requirement for active RNA and protein synthesis for cell death to proceed, suggesting an internally programmed process. One regulator of this process is the bcl-2 oncogene, which blocks apoptosis in vitro and in vivo and appears to normally control the timing of cell death in many cell lineages. The following projects are currently active in the lab:

a. Investigation of the mitochondrial functions of the Bcl-2 family of apoptotic regulatory proteins. Recent efforts have led to the discovery of novel small molecules that inhibit Bcl-2 and related proteins.

b. Structure-function analysis of Bcl-xL homodimers, with recent demonstration of x-ray crystal structure of 3D domain swapped dimers.

c. Analysis of mitochondrial proteomics and mitochondrial assembly in apoptosis, with a focus on the effects of Hsp90 inhibitors on mitochondrial protein turnover.

d. Investigation of the role of the c-myc transcription factor in bioenergetic regulation in different cell contexts, including cell growth and division, neoplastic transformation and apoptosis.

e. Analysis of cell signaling and transcriptional responses to nutrient excess, in particular glucose sensing mechanisms employed in cells susceptible to neoplastic transformation.

Memberships

American Association for the Advancement of Science
American Society for Cell Biology
American Society of Clinical Investigation
Biophysical Society
Mitochondria Research Society

Honors and Awards

2002, Member, American Society of Clinical Investigation
1991-1997, Scholar Award, Lucille P. Markey

Previous Positions

1999-2004, Associate Member, Fred Hutchinson Cancer Research Center, Clinical Research and Human Biology
1998-2005, Associate Professor, University of Washington, School of Medicine, Medicine, Gastroenterology
1992-1998, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research Division

 

Recent Publications

In Press
Hockenbery, DM, Strasser SI, McDonald GB.  In Press.  Gastrointestinal and hepatic complications. Thomas’ Hematopoietic Cell Transplantation.
2014
2012
2011
2010
2009
2008
2005