Tobias M. Hohl

Appointments and Affiliations

 
 
Memorial Sloan-Kettering Cancer Center
Department of Medicine
Assistant Member, Appointed: August 2013
Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease
Affiliate Investigator, Appointed: August 2013
Professional Headshot of Tobias M. Hohl

Mailing Address

Memorial Sloan-Kettering Cancer Center
1275 York Avenue, Box 9
New York, NY 10021
United States

Degrees

M.D., Cornell University, 2001.
Ph.D., Cornell University, 2001.
B.S., Duke University, Biochemistry and Molecular Biology, 1993.

Research Interests

I am a physician scientist with a clinical interest in treating infections in patients with highly compromised immune function. In this patient group, invasive fungal infections are a major infection-related cause of morbidity and mortality.

My laboratory research focuses on opportunistic fungal infections in the lung. Our studies center on host-pathogen interactions between the respiratory immune system and inhaled fungal spores. We are dissecting the molecular and cellular mechanisms that mediate host resistance to the fungal pathogen Aspergillus fumigatus, the most common etiologic agent of invasive aspergillosis.

In the laboratory, host-pathogen interactions are modeled using live fungal cells, mammalian cell lines, primary cell cultures, and transgenic or knockout mice with defined genetic alterations. Interactions between fungal and mammalian cells or intact mice are analyzed and quantitated using microscopic, flow cytometric, proteomic, and other standard methods in molecular biology, cell biology, and immunology.

Future Research

Research in the laboratory targets the following areas.

1. The dynamic role of monocytes and derivative cells in the induction of respiratory innate and CD4 T cell responses against Aspergillus spores.

2. The contribution of resident and recruited leukocyte subsets and the alveolar epithelium in the generation of inflammation following respiratory fungal challenge.

3. The requirement for specific innate immune signaling pathways (TLRs, dectin) in the cell stage-specific recognition of Aspergillus and the calibration of inflammation.

4. Immunomodulatory effects of antifungal therapies.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)
French: (Functional, Functional, Functional)
Italian: (Basic, Basic, Basic)

Memberships

American Society of Microbiology
Infectious Diseases Society of America

Honors and Awards

2009, Young Investigator Award, American Society of Microbiology
2008, Basic Sciences Research Award, 2nd Infections in Cancer Symposium, M.D. Anderson Cancer Center
2005, Basic Science Research Award, 1st Infection in Cancer Symposium, M.D. Anderson Cancer Center
2005, New York Infectious Diseases Society Fellows Basic Science Research Award, New York Infectious Diseases Society
1999, Julian R. Rachele Award of Excellence, Weill Graduate School of Medical Sciences of Cornell University.
1993, Phi Beta Kappa, Duke University
1992, Faculty Scholar Award, Duke University

Previous Positions

2009-2013, Assistant Member, Fred Hutchinson Cancer Research Center, Division of Vaccine and Infectious Diseases.
2007-2009, Instructor, Weill Medical College of Cornell University, Medicine
2007-2009, Assistant Attending Physician, Memorial Sloan-Kettering Cancer Center, Infectious Diseases

Funding

  • NIH RO1 AI093809: Initiation of the Immune Response Against Aspergillus fumigatus, 2011 to 2015.
  • American Heart Association (AHA): Monocyte-mediated Defense Against Candida albicans, 2010 to 2012.
  • Royalty Research Fund: Visualizing Neutrophil Trafficking and Function During Respiratory Fungal Infection, 2010 to 2011.
  • Cancer Center Support Grant (NIH/NCI): Visualizing Microbial Eradication during Pulmonary Infection, 2010 to 2011.
  • NIH KO8 AI071998: Monocyte-Mediated Defense Against Aspergillus fumigatus, 2008 to 2012.
  • Charles F. Revson Foundation: Biomedical Research Fellow, 2006 to 2007.

 

Recent Publications

2014
2013
Fisher, CE, Leisenring W, Boeckh MJ, Hohl TM.  2013.  Reply to Mikulska et al.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
Fisher, CE, Boeckh MJ, Hohl TM.  2013.  Reply to King and Stover.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2012
2011
Prlic, M, Hohl TM.  2011.  iNKTs Foil Fungi.. Cell host & microbe. 10(5):421-2. Abstract