Tobias M. Hohl
M.D., Cornell University, 2001.
Ph.D., Cornell University, 2001.
B.S., Duke University, Biochemistry and Molecular Biology, 1993.
I am a physician scientist with a clinical interest in treating infections in patients with highly compromised immune function. In this patient group, invasive fungal infections are a major infection-related cause of morbidity and mortality.
My laboratory research focuses on opportunistic fungal infections in the lung. Our studies center on host-pathogen interactions between the respiratory immune system and inhaled fungal spores. We are dissecting the molecular and cellular mechanisms that mediate host resistance to the fungal pathogen Aspergillus fumigatus, the most common etiologic agent of invasive aspergillosis.
In the laboratory, host-pathogen interactions are modeled using live fungal cells, mammalian cell lines, primary cell cultures, and transgenic or knockout mice with defined genetic alterations. Interactions between fungal and mammalian cells or intact mice are analyzed and quantitated using microscopic, flow cytometric, proteomic, and other standard methods in molecular biology, cell biology, and immunology.
Research in the laboratory targets the following areas.
1. The dynamic role of monocytes and derivative cells in the induction of respiratory innate and CD4 T cell responses against Aspergillus spores.
2. The contribution of resident and recruited leukocyte subsets and the alveolar epithelium in the generation of inflammation following respiratory fungal challenge.
3. The requirement for specific innate immune signaling pathways (TLRs, dectin) in the cell stage-specific recognition of Aspergillus and the calibration of inflammation.
4. Immunomodulatory effects of antifungal therapies.
(Reading, Writing, Speaking)
English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)
French: (Functional, Functional, Functional)
Italian: (Basic, Basic, Basic)
American Society of Microbiology
Infectious Diseases Society of America
Honors and Awards
2009, Young Investigator Award, American Society of Microbiology
2008, Basic Sciences Research Award, 2nd Infections in Cancer Symposium, M.D. Anderson Cancer Center
2005, Basic Science Research Award, 1st Infection in Cancer Symposium, M.D. Anderson Cancer Center
2005, New York Infectious Diseases Society Fellows Basic Science Research Award, New York Infectious Diseases Society
1999, Julian R. Rachele Award of Excellence, Weill Graduate School of Medical Sciences of Cornell University.
1993, Phi Beta Kappa, Duke University
1992, Faculty Scholar Award, Duke University
2009-2013, Assistant Member, Fred Hutchinson Cancer Research Center, Division of Vaccine and Infectious Diseases.
2007-2009, Instructor, Weill Medical College of Cornell University, Medicine
2007-2009, Assistant Attending Physician, Memorial Sloan-Kettering Cancer Center, Infectious Diseases
Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions.. Journal of immunology (Baltimore, Md. : 1950). 191(6):3358-72.. 2013.
Reply to Mikulska et al.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2013.
The Serum Galactomannan Index Predicts Mortality in Hematopoietic Stem Cell Transplant Recipients With Invasive Aspergillosis.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2013.
Inflammatory Monocytes Mediate Early and Organ-Specific Innate Defense During Systemic Candidiasis.. The Journal of infectious diseases.. 2013.
Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice.. Journal of immunology (Baltimore, Md. : 1950). 190(8):4175-84.. 2013.
Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation.. Microbes and infection / Institut Pasteur.. 2012.
iNKTs Foil Fungi.. Cell host & microbe. 10(5):421-2.. 2011.
Ly6G+ Neutrophils Are Dispensable for Defense against Systemic Listeria monocytogenes Infection.. Journal of immunology (Baltimore, Md. : 1950). 187(10):5293-8.. 2011.
In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis.. PLoS pathogens. 7(7):e1002145.. 2011.
Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation.. The Journal of experimental medicine. 208(2):369-81.. 2011.
Immune responses against Aspergillus fumigatus: what have we learned? Current opinion in infectious diseases. 24(4):315-22.. 2011.