Appointments and Affiliations
Ph.D., University of Oregon, Mathematics, 1990.
M.A., University of Oregon, Mathematics, 1987.
B.A., University of Minnesota, Mathematics, 1984.
Using differential and difference equations to model the biology of HIV and the immune system.
2001-2007: Senior Staff Scientist, Fred Hutchinson Cancer Research Center.
2003-2004: Research Associate Professor, Mathematics, North Carolina State University.
1995-2001: Staff Scientist, Fred Hutchinson Cancer Research Center.
1995: Statistical Research Associate, Fred Hutchinson Cancer Research Center.
1993-1995: Postdoctoral Fellow, Department of Biostatistics, University of Washington.
1990-1995 (on leave 9/93-6/95): Assistant Professor, Department of Mathematics, University of Missouri-Rolla.
2008-present: Director of Fred Hutchinson Center Public Health Sciences Biostatistics Shared Resource.
1999-present: Director of Biostatistics Core for Seattle Primary Infection Program (SeaPIP).
1999-2003: Director of Statistical Center for Acute/Early HIV Infection Network (AIEDRP).
- NIH/NIAID P30 AI-27757: Center for AIDS Research, University of Washington, Director, Biometrics Core, Co-Investigator (PI King Holmes, MD. PhD, University of Washington).
- NIH/NIAID P01 AI-057005: Immunological and Virological Events in Early HIV Infection, Director, Biostatistics Core, Co-Investigator (PI James Mullin, PhD).
- NIH R01 AI055343: Mathematical and Experimental Models for HIV Dynamics, Principal Investigator, April 2003 – December 2009.
- NIH R01 GM67299: Modeling, Estimation and Control in HIV Dynamics, Co-Investigator (Principal Investigator H.T. Banks, North Carolina State University), July 2002 - December 2004.
- Missouri Research Board: Modeling Dynamical Systems With Inverse Limits, Principal Investigator, June 1993- August 1994.
- Oak Ridge Associated Universities Junior Faculty Enhancement Award, Principal Investigator, June 1992-August 1993.
Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.. The Journal of infectious diseases. 207(8):1206-15.. 2013.
Do Workplace and Home Protective Practices Protect Farm Workers? Findings From the "For Healthy Kids" Study. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. 54(9):1163-1169.. 2012.
Efficient use of longitudinal CD4 counts and viral load measures in survival analysis.. Statistics in medicine.. 2012.
Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria and Death in Young Children.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 54(8):1137-44.. 2012.
Cervicovaginal shedding of hepatitis C viral RNA is associated with the presence of menstrual or other blood in cervicovaginal fluids.. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 50(1):4-7.. 2011.
Identifying the Early Post-HIV Antibody Seroconversion Period.. The Journal of infectious diseases. 204(4):526-533.. 2011.
IL28B genotype effects during early treatment with peginterferon and ribavirin in difficult-to-treat hepatitis C virus infection.. The Journal of infectious diseases. 204(3):419-25.. 2011.
Organophosphate pesticide exposure and residential proximity to nearby fields: evidence for the drift pathway.. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. 53(8):884-91.. 2011.
Dynamics of viral evolution and CTL responses in HIV-1 infection.. PloS one. 6(1):e15639.. 2011.
Prevalence and Impact of Minority Variant Drug Resistance Mutations in Primary HIV-1 Infection.. PloS one. 6(12):e28952.. 2011.
Strategies for increasing mammography screening in primary care in Chile: results of a randomized clinical trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 19(9):2254-61.. 2010.
Genetic drift of HIV populations in culture.. PLoS genetics. 5(3):e1000431.. 2009.
Monotypic human immunodeficiency virus type 1 genotypes across the uterine cervix and in blood suggest proliferation of cells with provirus.. Journal of virology. 83(12):6020-8.. 2009.
A decrease in albumin in early SIV infection is related to viral pathogenicity.. AIDS research and human retroviruses. 25(4):433-40.. 2009.
HIV dynamics in seminal plasma during primary HIV infection.. AIDS research and human retroviruses. 24(10):1269-74.. 2008.
The effect of mental illness, substance use, and treatment for depression on the initiation of highly active antiretroviral therapy among HIV-infected individuals.. AIDS patient care and STDs. 22(3):233-43.. 2008.
A comparison of methods for determining HIV viral set point.. Statistics in medicine. 27(1):121-39.. 2008.