Sarah Holte

Appointments and Affiliations

Principal Staff Scientist
Public Health Sciences Division
Biostatistics and Biomathematics Program
Principal Staff Scientist, Appointed 2007
University of Washington
Department of Biostatistics
Department of Global Health
Affiliate Associate Professor, Appointed 2004
 Professional Headshot of NAME

Mailing Address

Fred Hutchinson Cancer Research Center
M2-B500
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-6975
Fax: (206) 667-7004
sholte@fhcrc.org

Degrees

Ph.D., University of Oregon, Mathematics, 1990.
M.A., University of Oregon, Mathematics, 1987.
B.A., University of Minnesota, Mathematics, 1984.

Research Interests

Using differential and difference equations to model the biology of HIV and the immune system.

Previous Positions

2001-2007: Senior Staff Scientist, Fred Hutchinson Cancer Research Center.
2003-2004: Research Associate Professor, Mathematics, North Carolina State University.
1995-2001: Staff Scientist, Fred Hutchinson Cancer Research Center.
1995: Statistical Research Associate, Fred Hutchinson Cancer Research Center.
1993-1995: Postdoctoral Fellow, Department of Biostatistics, University of Washington.
1990-1995 (on leave 9/93-6/95): Assistant Professor, Department of Mathematics, University of Missouri-Rolla.

Additional Experience

2008-present: Director of Fred Hutchinson Center Public Health Sciences Biostatistics Shared Resource.
1999-present: Director of Biostatistics Core for Seattle Primary Infection Program (SeaPIP).
1999-2003: Director of Statistical Center for Acute/Early HIV Infection Network (AIEDRP).

Funding

  • NIH/NIAID P30 AI-27757: Center for AIDS Research, University of Washington, Director, Biometrics Core, Co-Investigator (PI King Holmes, MD. PhD, University of Washington).
  • NIH/NIAID P01 AI-057005: Immunological and Virological Events in Early HIV Infection, Director, Biostatistics Core, Co-Investigator (PI James Mullin, PhD).
  • NIH R01 AI055343: Mathematical and Experimental Models for HIV Dynamics, Principal Investigator, April 2003 – December 2009.
  • NIH R01 GM67299: Modeling, Estimation and Control in HIV Dynamics, Co-Investigator (Principal Investigator H.T. Banks, North Carolina State University), July 2002 - December 2004.
  • Missouri Research Board: Modeling Dynamical Systems With Inverse Limits, Principal Investigator, June 1993- August 1994.
  • Oak Ridge Associated Universities Junior Faculty Enhancement Award, Principal Investigator, June 1992-August 1993.

Recent Publications

2013
Bull, ME, Heath LM, McKernan-Mullin JL, Kraft KM, Acevedo L, Hitti JE, Cohn SE, Tapia KA, Holte SE, Dragavon JA et al..  2013.  Human immunodeficiency viruses appear compartmentalized to the female genital tract in cross-sectional analyses but genital lineages do not persist over time.. The Journal of infectious diseases. 207(8):1206-15. Abstract
2012
Coronado, GD, Holte SE, Vigoren EM, Griffith WC, Barr DB, Faustman EM, Thompson B.  2012.  Do Workplace and Home Protective Practices Protect Farm Workers? Findings From the "For Healthy Kids" Study. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. 54(9):1163-1169. Abstract
Liu, Y, Holte S, Rao U, McClure J, Konopa P, Swain VJ, Lanxon-Cookson E, Kim M, Chen L, Mullins JI.  2012.  A sensitive real-time PCR based assay to estimate the impact of amino acid substitutions on the competitive replication fitness of human immunodeficiency virus type 1 in cell culture.. Journal of virological methods. Abstract
Holte, SE, Randolph TW, Ding J, Tien J, McClelland RS, Baeten JM, Overbaugh J.  2012.  Efficient use of longitudinal CD4 counts and viral load measures in survival analysis.. Statistics in medicine. Abstract
Gwamaka, M, Kurtis JD, Sorensen BE, Holte S, Morrison R, Mutabingwa TK, Fried M, Duffy PE.  2012.  Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria and Death in Young Children.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 54(8):1137-44. Abstract
Graham, SM, Holte SE, Dragavon JA, Ramko KM, Mandaliya KN, McClelland SR, Peshu NM, Sanders EJ, Krieger JN, Coombs RW.  2012.  HIV-1 RNA may decline more slowly in semen than in blood following initiation of efavirenz-based antiretroviral therapy.. PloS one. 7(8):e43086. Abstract
Slyker, JA, Chung MH, Lehman DA, Kiarie J, Kinuthia J, Holte S, Tapia K, Njiri F, Overbaugh J, John-Stewart G.  2012.  Incidence and correlates of HIV-1 RNA detection in the breast milk of women receiving HAART for the prevention of HIV-1 transmission.. PloS one. 7(1):e29777. Abstract
2011
Wang, CC, Cook L, Tapia KA, Holte S, Krows M, Bagabag A, Santos A, Corey L, Jerome KR.  2011.  Cervicovaginal shedding of hepatitis C viral RNA is associated with the presence of menstrual or other blood in cervicovaginal fluids.. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 50(1):4-7. Abstract
Hecht, FM, Wellman R, Busch MP, Pilcher CD, Norris PJ, Margolick JB, Collier AC, Little SJ, Markowitz M, Routy J-P et al..  2011.  Identifying the Early Post-HIV Antibody Seroconversion Period.. The Journal of infectious diseases. 204(4):526-533. Abstract
Scott, J, Holte S, Urban T, Burgess C, Coppel E, Wang C, Corey L, McHutchison J, Goldstein D.  2011.  IL28B genotype effects during early treatment with peginterferon and ribavirin in difficult-to-treat hepatitis C virus infection.. The Journal of infectious diseases. 204(3):419-25. Abstract
Coronado, GD, Holte S, Vigoren E, Griffith WC, Barr DB, Faustman E, Thompson B.  2011.  Organophosphate pesticide exposure and residential proximity to nearby fields: evidence for the drift pathway.. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. 53(8):884-91. Abstract
Liu, Y, McNevin JP, Holte S, McElrath MJ, Mullins JI.  2011.  Dynamics of viral evolution and CTL responses in HIV-1 infection.. PloS one. 6(1):e15639. Abstract
Stekler, JD, Ellis GM, Carlsson J, Eilers B, Holte S, Maenza J, Stevens CE, Collier AC, Frenkel LM.  2011.  Prevalence and Impact of Minority Variant Drug Resistance Mutations in Primary HIV-1 Infection.. PloS one. 6(12):e28952. Abstract
2010
Püschel, K, Coronado G, Soto G, Gonzalez K, Martinez J, Holte S, Thompson B.  2010.  Strategies for increasing mammography screening in primary care in Chile: results of a randomized clinical trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 19(9):2254-61. Abstract
2009
Voronin, Y, Holte S, Overbaugh J, Emerman M.  2009.  Genetic drift of HIV populations in culture.. PLoS genetics. 5(3):e1000431. Abstract
Bull, ME, Learn GH, McElhone S, Hitti J, Lockhart D, Holte S, Dragavon J, Coombs RW, Mullins JI, Frenkel LM.  2009.  Monotypic human immunodeficiency virus type 1 genotypes across the uterine cervix and in blood suggest proliferation of cells with provirus.. Journal of virology. 83(12):6020-8. Abstract
Graham, SM, Holte S, Kimata JT, Wener MH, Overbaugh J.  2009.  A decrease in albumin in early SIV infection is related to viral pathogenicity.. AIDS research and human retroviruses. 25(4):433-40. Abstract
Bull, M, Learn G, Genowati I, McKernan J, Hitti J, Lockhart D, Tapia K, Holte S, Dragavon J, Coombs R et al..  2009.  Compartmentalization of HIV-1 within the female genital tract is due to monotypic and low-diversity variants not distinct viral populations.. PloS one. 4(9):e7122. Abstract
2008
Stekler, J, Sycks BJ, Holte S, Maenza J, Stevens CE, Dragavon J, Collier AC, Coombs RW.  2008.  HIV dynamics in seminal plasma during primary HIV infection.. AIDS research and human retroviruses. 24(10):1269-74. Abstract
Tegger, MK, Crane HM, Tapia KA, Uldall KK, Holte SE, Kitahata MM.  2008.  The effect of mental illness, substance use, and treatment for depression on the initiation of highly active antiretroviral therapy among HIV-infected individuals.. AIDS patient care and STDs. 22(3):233-43. Abstract
Mei, Y, Wang L, Holte SE.  2008.  A comparison of methods for determining HIV viral set point.. Statistics in medicine. 27(1):121-39. Abstract