Li Hsu

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Biostatistics
Public Health Sciences
Full Member, Appointed: 2005
University of Washington
School of Public Health and Community Medicine
Biostatistics
Affiliate Associate Professor, Appointed: 2000
Professional Headshot of Li Hsu

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N.
PO Box 19024, M2-B500
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-2854
Fax: (206) 667-7004
lih@fhcrc.org

Degrees

Ph.D., University of Washington, Biostatistics, 1994.
M.S., University of Washington, Biostatistics, 1991.
B.S., Nanjing University, Computer Science, 1989.

Research Interests

My principal research area is statistical genomics. These include assessing familial aggregation using variable age at onset as disease outcomes, discovering latent genes via linkage and association techniques, and characterizing the effect of the genes and their interaction with environmental risk factors on the time course of the disease. I have been involved in a number of family studies, such as case-control population based family studies of early onset breast cancer and prostate cancer and a school-based family study of learning disabilities.

I am also interested in the large scale of genomic data that are generated using the high throughput technologies. I am developing methods for evaluating the genome-wide pattern for the loss of heterzygosity (LOH) using the single nucleotide polymorphisms data from microarray chip. It is hypothesized that the genome-wide pattern of LOH may shed light on the mechanisms of tumor initiation and expansion. Complementary to the LOH study, I am also studying the methods for analyzing the gene expression data from the spotted array. Understanding the gene expression changes between tumor and normal tissues may help in clinical diagnosis, yielding useful biomarkers for early diagnosis, elucidating the genetic pathway, and mechanisms of cell cycles.

Additional Experience

Academic Experiences:

Associate Editor for Biometrics, 2000-present;
Statistical Editor for Journal of National Cancer Institute.

Industry

drug development and preventive strategies for cancer and other diseases.

Languages

(Reading, Writing, Speaking)

Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)

Memberships

American Society of Human Genetics
American Statistical Association
International Biometric Society

Honors and Awards

1991, Donovan J. Thompson Award for outstanding student in biostatistics, University of Washington
1991-1994, Merck, Sharp & Dohme Research Laboratories, Predoctoral Fellowship.,

Previous Positions

2000-2005, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics and Biomathematics Program
1997-2000, Assistant Member, Fred Hutchinson Cancer Research Center
1996-1997, Staff Scientist, Fred Hutchinson Cancer Research Center
1996-2000, Affiliate Assistant Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1994-1995, Research Fellow, Fred Hutchinson Cancer Research Center, Public Health Sciences

Funding

  • National Institutes of Health (NIH): Northwest Cancer Genetics Network (Potter), $659,993, 11/01/98 to 02/28/03.
  • DOD Idea Award: Genome-wide Examination of Allelic Loss in Lobular and Ductal Breast Cancer (Porter), 146,643, 09/01/02 to 08/31/05.
  • National Institutes of Health (NIH): Barrett's Esophagus: Predictors of Progression, Core C -- Bioinformatics and Biostatistics (Reid), 99,167, 07/01/02 to 06/30/07.
  • National Institutes of Health (NIH): Methods for Age at Onset Data in Genetic Epidemiology, $113,488, 06/01/97 to 05/31/02.
  • National Institutes of Health (NIH): Molecular Epidemiology of Testicular Carcinoma (Schwartz), 25,000, 04/01/02 to 05/31/05.
  • National Institutes of Health (NIH): Molecular Alterations in Lobular and Ductal Breast Cancer (Porter), 254,347, 04/01/02 to 03/31/06.
  • National Institutes of Health (NIH): Statistical Methods for Epidemiologic Studies(Prentice), $333,968, 01/01/01 to 12/31/05.

 

Recent Publications

2014
2013
Fitzgerald, LM, Kumar A, Boyle EA, Zhang Y, McIntosh LM, Kolb S, Stott-Miller M, Smith T, Karyadi DM, Ostrander EA et al..  2013.  Germline Missense Variants in the BTNL2 Gene Are Associated with Prostate Cancer Susceptibility.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(9):1520-8. Abstract
2012
Gong, J, Hutter C, Baron JA, Berndt S, Caan B, Campbell PT, Casey G, Chan AT, Cotterchio M, Fuchs CS et al..  2012.  A pooled analysis of smoking and colorectal cancer: timing of exposure and interactions with environmental factors.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(11):1974-85. Abstract