Ph.D., University of Washington, Biostatistics, 1994.
M.S., University of Washington, Biostatistics, 1991.
B.S., Nanjing University, Computer Science, 1989.
My principal research area is statistical genomics. These include assessing familial aggregation using variable age at onset as disease outcomes, discovering latent genes via linkage and association techniques, and characterizing the effect of the genes and their interaction with environmental risk factors on the time course of the disease. I have been involved in a number of family studies, such as case-control population based family studies of early onset breast cancer and prostate cancer and a school-based family study of learning disabilities.
I am also interested in the large scale of genomic data that are generated using the high throughput technologies. I am developing methods for evaluating the genome-wide pattern for the loss of heterzygosity (LOH) using the single nucleotide polymorphisms data from microarray chip. It is hypothesized that the genome-wide pattern of LOH may shed light on the mechanisms of tumor initiation and expansion. Complementary to the LOH study, I am also studying the methods for analyzing the gene expression data from the spotted array. Understanding the gene expression changes between tumor and normal tissues may help in clinical diagnosis, yielding useful biomarkers for early diagnosis, elucidating the genetic pathway, and mechanisms of cell cycles.
Associate Editor for Biometrics, 2000-present;
Statistical Editor for Journal of National Cancer Institute.
drug development and preventive strategies for cancer and other diseases.
(Reading, Writing, Speaking)
Chinese, Mandarin: (Fluent, Fluent, Fluent)
English: (Fluent, Fluent, Fluent)
American Society of Human Genetics
American Statistical Association
International Biometric Society
Honors and Awards
1991, Donovan J. Thompson Award for outstanding student in biostatistics, University of Washington
1991-1994, Merck, Sharp & Dohme Research Laboratories, Predoctoral Fellowship.,
2000-2005, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics and Biomathematics Program
1997-2000, Assistant Member, Fred Hutchinson Cancer Research Center
1996-1997, Staff Scientist, Fred Hutchinson Cancer Research Center
1996-2000, Affiliate Assistant Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1994-1995, Research Fellow, Fred Hutchinson Cancer Research Center, Public Health Sciences
Estimating the heritability of colorectal cancer.. Human molecular genetics.. 2014.
Estimating Risk with Time-to-Event Data: An Application to the Women's Health Initiative.. Journal of the American Statistical Association. 109(506):514-524.. 2014.
Gene-environment interaction involving recently identified colorectal cancer susceptibility loci.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
Genome-wide diet-gene interaction analyses for risk of colorectal cancer.. PLoS genetics. 10(4):e1004228.. 2014.
Imputation of coding variants in African Americans: better performance using data from the exome sequencing project.. Bioinformatics (Oxford, England).. 2013.
Germline Missense Variants in the BTNL2 Gene Are Associated with Prostate Cancer Susceptibility.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(9):1520-8.. 2013.
Calibrated predictions for multivariate competing risks models.. Lifetime data analysis.. 2013.
Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia.. Genes, chromosomes & cancer. 52(5):437-49.. 2013.
Genome-wide association study of serum selenium concentrations.. Nutrients. 5(5):1706-18.. 2013.
A unified mixed-effects model for rare-variant association in sequencing studies.. Genetic epidemiology. 37(4):334-44.. 2013.
SBERIA: Set-Based Gene-Environment Interaction Test for Rare and Common Variants in Complex Diseases.. Genetic epidemiology. 37(5):452-64.. 2013.
Phospholipase A2G1B polymorphisms and risk of colorectal neoplasia.. International journal of molecular epidemiology and genetics. 4(3):140-9.. 2013.
Bootstrap inference for network construction with an application to a breast cancer microarray study. The Annals of Applied Statistics. 7(1):391-417.. 2013.
A pooled analysis of smoking and colorectal cancer: timing of exposure and interactions with environmental factors.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(11):1974-85.. 2012.
Glutathione peroxidase tagSNPs: Associations with rectal cancer but not with colon cancer.. Genes, chromosomes & cancer. 51(6):598-605.. 2012.
Simultaneously testing for marginal genetic association and gene-environment interaction.. American journal of epidemiology. 176(2):164-73.. 2012.
Bias correction in the hierarchical likelihood approach to the analysis of multivariate survival data.. Biostatistics (Oxford, England). 13(3):384-97.. 2012.