Yunda Huang

Appointments and Affiliations

Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Division
Public Health Sciences Division
Statistical Center for HIV/AIDS Research and Prevention
Senior Staff Scientist, Appointed: 2009
Professional Headshot of Yunda Huang

Mailing Address

Fred Hutchinson Cancer Research Center
M2-C200
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-5780
Fax: (206) 667-4378
yunda@scharp.org

Degrees

Ph.D., University of California, Biostatistics, 2004.
B.S, University of Texas, Statistics, 1997.

Research Interests

  • Design and analysis of clinical trials for vaccines against infectious diseases
  • Statistical methods in immunological assay validation and evaluation
  • Statistical methods in equivalence testing
  • Immune correlates of protection
  • Meta-analysis

Previous Positions

2010-2011: Director, Data Analysis Unit, Statistical Center for HIV/AIDS Research and Prevention
2004-2009: Staff Scientist, Statistical Center for HIV/AIDS Research and Prevention.
2004: Bioinformatics Specialist, The Salk Institute, Plant Biology Laboratory.
2001-2003: Statistical Consultant, University of California, Los Angeles, Array Data Analysis Group, Department of Biostatistics.
2002: Research Assistant, University of California, Los Angeles, Department of Human Genetics and Department of Biostatistics.
2000-2002: Research Assistant, University of California, Los Angeles, Department of Biostatistics.
1999: Research Assistant, University of Texas at Austin, Department of Civil Engineering.

Additional Experience

Collaboration of AIDS Vaccine Discovery (CAVD), Head, Biostatistics Collaboration, Appointed: 2011
Statistical Center for HIV/AIDS Research and Prevention, HVTN SDMC Leadership Team
Member, Appointed: 2011
2009: Invited member, FHCRC/UW delegation to China CDC, Delegation Chairs: Dr. Lee Hartwell
2008: Invited member, FHCRC/UW delegation to China CDC, Beijing, Delegation Chairs: Drs. Tuofu Zhu & Steve Self

Memberships

2004-present: International Society for Computational Biology
2003-present: American Statistical Association

Honors and Awards

2002-2003: Dissertation Fellowship, Graduate Division at UCLA
2002-2003: Phi Beta Kappa Fellowship (PBK)
2002: Raymond D. Goodman Scholarship, School of Public Health at UCLA
2000: Young Investigator Award, Transplant 2000
2000: School of Public Health Travel Grant, UCLA
1999: George R. Jordan, Actuarial Science Scholarship, UT Austin

Editorial Positions

2010-present: Editorial Board Member, Journal of AIDS & Clinical Research

Funding

  • Bill & Melinda Gates Foundation, Vaccine Immunology Statistical Center (VISC), Head of Biostatistical Unit, (PI: Steven Self), 2011-2016.
  • NIH/NIAID: Leadership for HIV/AIDS Clincal Trials Networks: HIV Vaccine Trials Network, (PI: Steven Self), 2006-2013.

Recent Publications

In Press
Duerr, A, Huang Y.  In Press.  Extended follow-up of participants in a cell-mediated immunity HIV vaccine trial (Step study): Vaccine effect on HIV acquisition in male wanes over time. Journal of Infectious Diseases.
2013
Duerr, A, Huang Y, Buchbinder S, Coombs RW, Sanchez J, del Rio C, Casapia M, Santiago S, Huang Y, Gilbert P et al..  2013.  Reply to richie and villasante.. The Journal of infectious diseases. 207(4):690-2.
2012
Duerr, A, Huang Y, Buchbinder S, Coombs RW, Sanchez J, del Rio C, Casapia M, Santiago S, Gilbert P, Corey L et al..  2012.  Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study).. The Journal of infectious diseases. 206(2):258-266. Abstract
Frahm, N, Decamp AC, Friedrich DP, Carter DK, Defawe OD, Kublin JG, Casimiro DR, Duerr A, Robertson MN, Buchbinder SP et al..  2012.  Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine.. The Journal of clinical investigation. 122(1):359-67. Abstract
Huang, Y, Gottardo R.  2012.  Comparability and reproducibility of biomedical data.. Briefings in bioinformatics. Abstract
Huang, Y, Huang Y, Moodie Z, Li S, Self SG.  2012.  Comparing and combining data across multiple sources via integration of paired-sample data to correct for measurement error.. Statistics in medicine. 31(28):3748-59. Abstract
Haynes, BF, Gilbert PB, McElrath MJ, Zolla-Pazner S, Tomaras GD, Alam MS, Evans DT, Montefiori DC, Karnasuta C, Sutthent R et al..  2012.  Immune-correlates analysis of an HIV-1 vaccine efficacy trial.. The New England journal of medicine. 366(14):1275-86. Abstract
Todd, CA, Greene KM, Yu X, Ozaki DA, Gao H, Huang Y, Wang M, Li G, Brown R, Wood B et al..  2012.  Development and implementation of an international proficiency testing program for a neutralizing antibody assay for HIV-1 in TZM-bl cells.. Journal of immunological methods. 375(1-2):57-67. Abstract
2011
De Rosa, SC, Thomas EP, Bui J, Huang Y, DeCamp A, Morgan C, Kalams SA, Tomaras GD, Akondy R, Ahmed R et al..  2011.  HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable.. Journal of immunology (Baltimore, Md. : 1950). 187(6):3391-3401. Abstract
Friedrich, D, Jalbert E, Dinges WL, Sidney J, Sette A, Huang Y, McElrath MJ, Horton H.  2011.  Vaccine-induced HIV-specific CD8+ T cells utilize preferential HLA alleles and target-specific regions of HIV-1.. Journal of acquired immune deficiency syndromes (1999). 58(3):248-52. Abstract
Baden, LR, Blattner WA, Morgan C, Huang Y, Defawe OD, Sobieszczyk ME, Kochar N, Tomaras GD, McElrath MJ, Russell N et al..  2011.  Timing of Plasmid Cytokine (IL-2/Ig) Administration Affects HIV-1 Vaccine Immunogenicity in HIV-Seronegative Subjects.. The Journal of infectious diseases. 204(10):1541-1549. Abstract
Barnabas, RV, Wasserheit JN, Huang Y, Janes H, Morrow RA, Fuchs J, Mark KE, Casapia M, Mehrotra DV, Buchbinder SP et al..  2011.  Impact of Herpes Simplex Virus Type 2 on HIV-1 Acquisition and Progression in an HIV Vaccine Trial (the Step Study).. Journal of acquired immune deficiency syndromes (1999). 57(3):238-244. Abstract
Spearman, P, Lally MA, Elizaga M, Montefiori D, Tomaras GD, McElrath MJ, Hural J, De Rosa SC, Sato A, Huang Y et al..  2011.  A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers.. The Journal of infectious diseases. 203(8):1165-73. Abstract
Pine, SO, Kublin JG, Hammer SM, Borgerding J, Huang Y, Casimiro DR, McElrath MJ.  2011.  Pre-existing adenovirus immunity modifies a complex mixed Th1 and Th2 cytokine response to an Ad5/HIV-1 vaccine candidate in humans.. PloS one. 6(4):e18526. Abstract
2010
Gill, DK, Huang Y, Levine GL, Sambor A, Carter DK, Sato A, Kopycinski J, Hayes P, Hahn B, Birungi J et al..  2010.  Equivalence of ELISpot assays demonstrated between major HIV network laboratories.. PloS one. 5(12):e14330. Abstract
Rohan, LC, Moncla BJ, Kunjara Na Ayudhya RP, Cost M, Huang Y, Gai F, Billitto N, Lynam JD, Pryke K, Graebing P et al..  2010.  In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide.. PloS one. 5(2):e9310. Abstract
Huang, Y.  2010.  A Comparison of Testing Parameters and the Implementation of a Group Sequential Design for Equivalence Studies Using Paired-Sample Analysis. Statistics in Biopharmaceutical Research. 2(3):336-347.
2009
Huang, Y, Gilbert PB, Montefiori DC, Self SG.  2009.  Simultaneous Evaluation of the Magnitude and Breadth of a Left and Right Censored Multivariate Response, with Application to HIV Vaccine Development.. Statistics in biopharmaceutical research. 1(1):81-91. Abstract
2008
Shulman, N, Bellew M, Snelling G, Carter D, Huang Y, Li H, Self SG, McElrath MJ, De Rosa SC.  2008.  Development of an automated analysis system for data from flow cytometric intracellular cytokine staining assays from clinical vaccine trials.. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 73(9):847-56. Abstract