Keith R. Jerome

Appointments and Affiliations

 
 

Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Division
Associate Member

University of Washington
Associate Professor, Laboratory Medicine
Adjunct Associate Professor, Microbiology
Head, Virology Division
Director, Molecular Virology Laboratory, Laboratory Medicine

Professional Headshot of Keith R. Jerome

Mailing Address

1100 Fairview Ave. N.
E5-110
Seattle, Washington 98109
United States

Degrees

M.D., Duke University, 1993.
Ph.D., Duke University, Immunology, 1992.
B.S., Georgetown College, Chemistry, 1985.

Research Interests

My research focuses on chronic and latent viruses, their immune evasion mechanisms, and potential curative therapeutic approaches to these infections. Recent work involves the use of DNA editing enzymes such as homing endonucleases and zinc finger nucleases to specifically target latent viral DNA for cleavage and inactivation. This approach may allow precise elimination of functional viral DNA from infected cell reservoirs, offering the prospect of cure for HIV, hepatitis B, herpes simplex, and human papillomavirus infections.

Clinically, I serve as Director of the University of Washington molecular virology laboratory, and consult regarding all aspects of virology testing. Specific areas of interest include real time PCR, automation of nucleic acid extraction, and diagnosis of disease caused by herpesviruses, enterovirus, JC and BK viruses, parvovirus B19, and hepatitis virus.

Memberships

American Society for Microbiology
Infectious Diseases Society of America

Funding

  • University of Washington Center for AIDS Research (CFAR):  Scientific Working Group – Curative Therapies for HIV, 2013 to 2018.
  • National Institutes of Health (NIH): Target Modification of Host and Proviral DNA to Treat Latent HIV Infection, 2011 to 2015.
  • University of Washington Center for AIDS Research: Dendritic Cell-Based Delivery for Genetic Therapy of Latent HIV Infection,  2011 to 2012.
  • National Institutes of Health (NIH): Hepatitis B Research Network Central Lab, 2010 to 2015.
  • Bill & Melinda Gates Foundation: Homing Endonucleases for the Cure of Latent HIV Infection, 2010 to 2012.
  • Northwest Genome Engineering Consortium/Seattle Children's: Homing Endonucleases for the Cure of Latent HIV Infections in Humans, 2009 to 2011.

 

Recent Publications

2014
2013
Weber, ND, Stone D, Jerome KR.  2013.  TALENs targeting HBV: designer endonuclease therapies for viral infections.. Molecular therapy : the journal of the American Society of Gene Therapy. 21(10):1819-20.
De Roos, AJ, Martinez-Maza O, Jerome KR, Mirick DK, Kopecky KJ, Madeleine MM, Magpantay L, Edlefsen KL, LaCroix AZ.  2013.  Investigation of Epstein-Barr Virus as a Potential Cause of B-Cell Non-Hodgkin Lymphoma in a Prospective Cohort.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
2012
2011