Charles L. Kooperberg
Ph.D., University of California, Berkeley, Statistics, 1991.
M.A., University of California, Berkeley, Statistics, 1988.
B.Sc., Delft University of Technology, Mathematics, 1985.
Adaptive function estimation for genomic data .
My main research area is nonparametric function estimation and the analysis of high dimensional data, in particular as applied to genomic and proteomics data.
The publication of the sequence of the human genome and breakthroughs in the high throughput technologies for single nucleotide polymorphism (SNP) genotyping, gene expression, and protein measurements have offered new opportunities for the study of genome complexity. New technologies are generating large amounts of high-dimensional data at an astounding speed. Relative to the high dimension of the data the number of independent samples is often rather small, either because the techniques are too expensive, or because it is hard to obtain enough independent biological samples. Clearly, the development of new statistical techniques is required for the extraction of useful biological information from such data.
Adaptive regression methods, which combine variable selection and nonlinear modeling, are well suited for many of these problems. In my research I try to develop and enhance these methods to address the practical problems that arise directly from several collaborative projects. In particular I focus on association studies with SNP, microarray, and proteomics data.
For SNP association studies we have developed Logic Regression. Logic Regression is a methodology for regression problems in which all (most) of the predictors are binary, and in which our interest is to discover potential high order interactions between these predictors. In Logic Regression new predictors that are logic (Boolean) combinations of the binary predictors are constructed.
There are numerous situations in which data is generated by some (unknown) mechanism, where interest lies in estimating a function that is related to a model for the data. In the polynomial spline approach we model such a function to be in a linear space of smooth piecewise polynomials (splines). In practice we often use stepwise algorithms to determine this space adaptively. For example, in the popular proportional hazards model the dependence of survival times on the covariates is modeled fully parametrically. Hazard regression (HARE) employs an adaptive algorithm based on splines to model the conditional log-hazard function. It does not assume a proportional hazards model, but it contains these models as a special subclass. I am both interested in developing similar nonparametric methodologies for other function estimation problems, as in the extension of existing methods to applications of these methodologies.
In addition, I am actively involved in the activities of the Clinical Coordinating Center of the Women's Health Initiative. This is a 15-year program that involves a clinical trial of 67,500 postmenopausal women and an observational study of an additional 100,000 women. The primary outcomes that are studied are breast cancer, colorectal cancer, coronary heart disease and hip fractures. Within the coordinating center I am primarily involved in the outcomes procedures and the periodic reporting to the Data Safety and Monitoring Board.
1999-2003, Affiliate Associate Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1997-2002, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics
1991-1997, Assistant Professor, University of Washington, College of Arts and Sciences, Statistics
Leveraging Multi-ethnic Evidence for Mapping Complex Traits in Minority Populations: An Empirical Bayes Approach.. American journal of human genetics. 96(5):740-52.. 2015.
The TERT gene harbors multiple variants associated with pancreatic cancer susceptibility.. International journal of cancer. Journal international du cancer.. 2015.
Characterization of large structural genetic mosaicism in human autosomes.. American journal of human genetics. 96(3):487-97.. 2015.
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.. Nature. 518(7537):102-6.. 2015.
Genetic studies of body mass index yield new insights for obesity biology.. Nature. 518(7538):197-206.. 2015.
New genetic loci link adipose and insulin biology to body fat distribution.. Nature. 518(7538):187-96.. 2015.
Genetic variation predicts serum lycopene concentrations in a multiethnic population of postmenopausal women.. The Journal of nutrition. 145(2):187-92.. 2015.
Hormone Use, Reproductive History and Risk of Lung Cancer: The Women's Health Initiative Studies.. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.. 2015.
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses.. Human molecular genetics.. 2014.
Genome-wide interaction study of smoking and bladder cancer risk.. Carcinogenesis.. 2014.
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.. The New England journal of medicine. 371(1):22-31.. 2014.
Comparative Analysis of Metabolic Syndrome Components in over 15,000 African Americans Identifies Pleiotropic Variants: Results from the PAGE Study.. Circulation. Cardiovascular genetics.. 2014.
A variational Bayes discrete mixture test for rare variant association.. Genetic epidemiology. 38(1):21-30.. 2014.
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.. American journal of human genetics. 94(2):223-32.. 2014.
Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.. American journal of human genetics. 94(2):233-45.. 2014.
Meta-analysis of loci associated with age at natural menopause in African-American women.. Human molecular genetics.. 2014.
Meta-analysis of gene-level tests for rare variant association.. Nature genetics. 46(2):200-4.. 2014.
Leveraging population admixture to characterize the heritability of complex traits.. Nature genetics. 46(12):1356-62.. 2014.
Trans-ethnic Meta-analysis of White Blood Cell Phenotypes.. Human molecular genetics.. 2014.