Kenneth J. Kopecky
Ph.D., Oregon State University, 1977.
M.S., Oregon State University, 1975.
Southwest Oncology Group Statistical Center (Leukemia And Leukemia Biology) And Radiation Epidemiology.
The Leukemia Committee and Leukemia Biology Program of the Southwest Oncology Group conduct a variety of studies concerning adult leukemias. These include clinical trials of new and promising treatments for the various kinds of leukemia, as well as laboratory studies to elucidate the biological mechanisms underlying the pathogenesis and prognosis of these diseases. The investigators at the Southwest Oncology Group Statistical Center collaborate in the design, conduct, analysis and reporting of these studies.
A continuing major focus of the Southwest Oncology Group's leukemia research is the problem of multidrug resistance. Patients whose leukemia is resistant to remission induction therapy have a very poor prognosis. Recent and ongoing studies have shown that such resistance is a complex phenomenon, possibly involving multiple mechanisms, some of which protect leukemic cells from cytotoxic agents,and others of which may interfere with that protection. The Group's studies are intended to elucidate these mechanisms, with the ultimate goal of finding ways to overcome multidrug resistance.
Radiation epidemiology is the study of how risks of diseases such as certain types of cancer are affected when people are exposed to radiation. The Hanford Thyroid Disease Study investigated whether thyroid disease, including thyroid cancer, has been increased among persons exposed to radioactive iodine released from the Hanford Nuclear Site in south-central Washington State during the 1940s and 1950s. Scientists from the Fred Hutchinson Cancer Research Center are also engaged with Russian colleagues in a multinational project (the International Consortium for Research on the Health Effects of Radiation) to investigate the radiation doses and health consequences in areas of Russia contaminated by fallout from the Chernobyl accident in April 1986. This project includes a case-control studies of thyroid cancer and leukemia among persons who were exposed to radiation from the accident.
SWOG Cooperative Group Biorepository Resource: Access for Scientific Research Studies.. Clinical cancer research : an official journal of the American Association for Cancer Research. 17(16):5239-46.. 2011.
Relationship between radiation exposure and risk of second primary cancers among atomic bomb survivors.. Cancer research. 70(18):7187-98.. 2010.
Incidence of myelodysplastic syndromes within a nonprofit healthcare system in western Washington state, 2005-2006.. American journal of hematology. 85(10):765-70.. 2010.
Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study.. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 24(5):909-13.. 2010.
Timing of menarche and first birth in relation to risk of breast cancer in A-bomb survivors.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 19(7):1746-54.. 2010.
Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials.. JAMA : the journal of the American Medical Association. 301(22):2349-61.. 2009.
Basal cell skin cancer after total-body irradiation and hematopoietic cell transplantation.. Radiation research. 171(2):155-63.. 2009.
Identification of genes with abnormal expression changes in acute myeloid leukemia.. Genes, chromosomes & cancer. 47(1):8-20.. 2008.
ret/PTC activation is not associated with individual radiation dose estimates in a pilot study of neoplastic thyroid nodules arising in Russian children and adults exposed to Chernobyl fallout.. Thyroid : official journal of the American Thyroid Association. 18(8):839-46.. 2008.
Thyrotropin levels in a population with no clinical, autoantibody, or ultrasonographic evidence of thyroid disease: implications for the diagnosis of subclinical hypothyroidism.. The Journal of clinical endocrinology and metabolism. 93(4):1224-30.. 2008.