Mario Kratz

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Cancer Prevention Program
Associate Member, Appointed: 2013
 
University of Washington
School of Public Health
Epidemiology
Research Associate Professor, Appointed: 2013
 
University of Washington
School of Medicine
Medicine
Metabolism, Endocrinology, and Nutrition
Adjunct Research Associate Professor, Appointed: 2013
 
University of Washington
Diabetes Research Center
Immunology and Inflammation Core
Associate Director
 
University of Washington
School of Public Health
Nutritional Sciences Program
Core Faculty Member
Professional Headshot of Mario  Kratz

Mailing Address

Mail Stop M4-B402
1100 Fairview Ave N
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-7362
Fax: (206) 667-7850
mkratz@fredhutch.org

Degrees

Ph.D., University of Bonn, Nutritional Sciences, 2001.
M.S., University of Bonn, Nutritional Sciences, 1996.

Research Interests

Dr. Kratz’s research focuses on the relationship between diet, obesity, and chronic diseases such as type 2 diabetes, cardiovascular disease, and cancers associated with obesity. Current projects include controlled dietary intervention studies in humans to better understand how diet composition affects energy and glucose homeostasis, or major determinants of glucose homeostasis including insulin sensitivity, pancreatic beta-cell function, liver fat content, and low-grade chronic inflammation. We are also conducting translational studies to improve our understanding of the etiology of low-grade chronic adipose tissue inflammation, and its relationship to adiposity and insulin resistance.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)

Memberships

American Diabetes Association
American Society for Nutrition

Previous Positions

2007-2013, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Cancer Prevention Program
2008-2013, Research Assistant Professor, University of Washington, School of Public Health, Epidemiology
2003-2007, Post-doctoral fellow, University of Washington, Medicine, Metabolism, Endocrinology & Nutrition
2001-2003, Post-doctoral fellow, Leibnitz-Institute of Arteriosclerosis Research
1997-2001, Ph.D. student, Leibnitz-Institute of Arteriosclerosis Research, Muenster, Germany

Current Studies

  • Diet and Metabolic Inflammation (AIM) Study
  • Adipose Tissue Inflammation & Therapeutic Estrogen Suppression Trial (ATTEST)
  • The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis
  • Inflammation in Diabetes Etiology Assessment (IDEA) Study
  • Metabolically Activated Macrophage in Obesity & Insulin Resistance (MAC) Study

Funding

  • 2015-2017 Dairy Research Institute award (PI: Kratz) for the project The impact of low-fat and full-fat dairy consumption on glucose homeostasis. Role in project: Principal Investigator.
  • 2014-2015 Fred Hutchinson Cancer Research Center Cancer Center Support Grant (CCSG) Pilot Award (PI: Kratz) for the project Diet-induced metabolic activation as a key initiator of low-grade chronic inflammation. Role in project: Principal Investigator
  • 2013-2014 Fred Hutchinson Cancer Research Center Specialized Program of Research Excellence (SPORE) Pilot & Feasibility award (PI: Kratz, Korde) for the project Aromatase Inhibitor Therapy: Effects on Adipose Tissue Inflammation. Role in project: Co-Principal Investigator.
  • 2013-2016 NIH R24 MD008068 (PI: Ko, Perry). National Institute on Minority Health and Health Disparities (NIMHD) award for the project Collaboration for a Healthy Community. Role in project: Co-Investigator
  • 2012-2017 NIH U54 HD0424541 (PI: Bremner, project PI: Page). National Institute of Child Health and Human Development (NICHD) award for the Male Contraception Research Center, project Impact of Male Hormonal Contraceptives on Risk Factors for Cardiometabolic Disease. Role in the project: Co-Investigator.
  • 2012-2017 NIH P30 DK017047 (PI: Kahn). National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) award for the Diabetes Research Center. Role in project: Co-Investigator.
  • 2011-2016 NIH R01 DK089036 (PI: Schur). National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) award for the project A Twin Study of Obesity Pathogenesis using fMRI. Role in the project: Co-Investigator.
  • 2010-2015 NIH P50 CA148143 (PI: Thompson, project PI: Neuhouser). National Cancer Institute (NCI) grant for the project Understanding and Preventing Breast Cancer Disparities in Latinas. Role in project: Co-Investigator.
  • 2011-2014 NIH R21 HL 108257 (PI: Kratz). National Heart, Lung, and Blood Institute (NHLBI) grant for the project Dietary Fructose and Low-Grade Inflammation. Role in project: Principal Investigator.
  • 2011-2014 NIH R01 DK089528 (PI: Cummings, Flum). National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) award for the project Feasibility, Efficacy, and Mechanisms of Surgical vs Medical Diabetes Therapy. Role in project: Co-Investigator.
  • 2011-2014 University of Washington Diabetes Research Center (DRC) Pilot & Feasibility Award (PI: Kratz) for the project Dietary Fructose and Intestinal Permeability. Role in project: Principal Investigator.
  • 2010-2013 NIH R21 CA143248 (PI: Kratz). National Cancer Institute (NCI) grant for the project Adipose tissue inflammation and estrogen synthesis. Role in project: Principal Investigator.
  • 2011-2013 University of Washington Nutrition Obesity Research Center (NORC) Pilot & Feasibility Award (PI: Kratz) for the project Vitamin D and Chronic Low-Grade Adipose Tissue Inflammation. Role in project: Principal Investigator.
  • 2009-2013 American Diabetes Association 7-09-CT-36 (PI: Kratz). Clinical/Translational Research Award for the project Inflammatory dendritic cells in adipose tissue inflammation and insulin resistance. Role in project: Principal Investigator.
  • 2008-2009 NIH Transdisciplinary Research on Energetics and Cancer (TREC) Developmental Research Project Grant for the Fat & Inflammation-Study. Role in project: Principal Investigator.
  • 2008-2009 University of Washington Institute of Translational Health Sciences (ITHS) Technology Access Grant for the study Effects of fructose and glucose on caloric intake and eating behavior - A pilot study using Functional Magnetic Resonance Imaging. Role in project: Principal Investigator.
  • 2007-2008 NIH Transdisciplinary Research on Energetics and Cancer (TREC) Developmental Research Project Grant for the study The impact of diet and physical activity on the number and type of macrophages in subcutaneous abdominal adipose tissue. Role in project: Principal Investigator.
  • 2006-2008 American Diabetes Association Clinical Research Award (PI: Weigle) for Study The impact of dietary omega-3-polyunsaturated fatty acids on the regulation of body weight. Role in project: Co-Investigator.
  • 2004-2005 German Research Foundation [Deutsche Forschungsgemeinschaft (DFG)] Postdoctoral Fellowship award [KR 2284/2-1 (PI: Kratz)] for project entitled The impact of dietary -3-polyunsaturated fatty acids on the regulation of body weight. Role in project: Principal Investigator.
  • 2004-2006 Dick & Julia McAbee Endowed Fellowship in Diabetes Research (PI: Kratz) for the project The impact of dietary -3-polyunsaturated fatty acids on the regulation of body weight. Role in project: Principal Investigator.
  • 2002-2003 Stifterverband für die Deutsche Wissenschaft grant [TS 022/12372/2002 (PI: Kratz)] for the project Effect of margarines enriched in plant sterols or stanols on the serum plant sterol and stanol concentrations in subjects heterozygous for mutations known to cause sitosterolemia. Role in project: Principal Investigator.
  • 2000-2002 Union for the Promotion of oil- and protein-producing plants & Central Marketing Agency of the German Agricultural Industry grant (PI: Wahrburg, Kratz) for the project Comparison of a high-fat and a low-fat diet, both rich in monounsaturated fatty acids, with regards to composition, oxidizability, and atherogenicity of low-density lipoprotein. Role in the project: Co-Principal Investigator.

Recent Publications

2015
2014
Hardikar, S, Onstad L, Song X, Wilson AM, Montine TJ, Kratz M, Anderson GL, Blount PL, Reid BJ, White E et al..  2014.  Inflammation and oxidative stress markers and esophageal adenocarcinoma incidence in a Barrett's esophagus cohort.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 23(11):2393-403. Abstract
2013
2012
2011
2010
2009