Andrea Z. Lacroix
Ph.D., University of North Carolina, 1984.
Dr. Andrea LaCroix has expertise in epidemiologic methods; large randomized controlled clinical trials; osteoporosis and fracture; women's health; aging; and cardiovascular disease. Dr. LaCroix is Co-Principal Investigator of the Women's Health Initiative Clinical Coordinating Center at the Fred Hutchinson Cancer Research Center; Scientific Investigator at the Center for Health Studies, Group Health Cooperative of Puget Sound; and Professor of Epidemiology at the University of Washington in Seattle. Her research focuses on prevention of osteoporosis and fracture in women of all ages, as well as prevention of coronary disease and cancer. She has published widely on these topics with an emphasis on identifying effective pharmacologic and lifestyle interventions for healthy aging among women.
In the past year, Dr. LaCroix published the results of a three-year randomized controlled trial started in 1993 showing that low dose hydrochlorothiazide preserved bone density at the hip and spine in older adults. She also presented the results of an analysis from the Women's Health Initiative Observational Study, a prospective cohort study of 93,724 women, showing that women who took statin medications for lipid lowering had similar rates of hip, lower arm/wrist and other clinical fractures as women who did not take statin medications. These findings contrast with earlier studies showing a benefit of statins on risk of hip fracture. Dr. LaCroix and her colleagues have developed and tested a workbook designed to assist women with making informed decisions about whether or not to take hormone replacement therapy. Evaluation of the workbook with a randomized controlled trial showed significant improvements in knowledge about HRT among women who received the workbook. This document will be published in the spring 2001 catalogue of the US Government Printing Office and will also be disseminated through a website under development by the Centers for Disease Control. Dr. LaCroix is collaborating as the senior investigator on a new randomized trial testing the effects of selected herbal remedies on vasomotor symptoms, cardiovascular risk factors and bone density in symptomatic perimenopausal women.
American Heart Association
American Public Health Association
American Society for Bone and Mineral Research
Society for Epidemiologic Research
Dispositional Optimism and Terminal Decline in Global Quality of Life.. Developmental psychology.. 2015.
Global quality of life modifies terminal change in physical functioning among older adult women.. Age and ageing. 44(3):520-4.. 2015.
A comparison of self-reported oral contraceptive use and automated pharmacy data in perimenopausal and early postmenopausal women.. Annals of epidemiology. 25(1):55-9.. 2015.
Genetic factors associated with longevity: a review of recent findings.. Ageing research reviews. 19:1-7.. 2015.
Placebo improvement in pharmacologic treatment of menopausal hot flashes: time course, duration, and predictors.. Psychosomatic medicine. 77(2):167-75.. 2015.
Concern about the use of venlafaxine to treat vasomotor symptoms-reply.. JAMA internal medicine. 175(4):658-9.. 2015.
Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers.. International journal of cancer. Journal international du cancer.. 2014.
Sexual Function in Women on Estradiol or Venlafaxine for Hot Flushes: A Randomized Controlled Trial.. Obstetrics and gynecology.. 2014.
Effects of Escitalopram on Markers of Bone Turnover: a Randomized Clinical Trial.. The Journal of clinical endocrinology and metabolism. :jc20142288.. 2014.
Factors Associated with Successful Discontinuation of Hormone Therapy.. Journal of women's health (2002).. 2014.
Cytokines in serum in relation to future non-Hodgkin lymphoma risk: Evidence for associations by histologic subtype.. International journal of cancer. Journal international du cancer.. 2014.
Empirically Based Composite Fracture Prediction Model from the Global Longitudinal Study of Osteoporosis in Postmenopausal Women (GLOW).. The Journal of clinical endocrinology and metabolism. :jc20133468.. 2014.
Obesity and late-age survival without major disease or disability in older women.. JAMA internal medicine. 174(1):98-106.. 2014.
Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study.. The American journal of clinical nutrition.. 2014.
Biomarker-calibrated protein intake and bone health in the Women's Health Initiative clinical trials and observational study.. The American journal of clinical nutrition.. 2014.
Sedentary Behavior and Mortality in Older Women: The Women's Health Initiative.. American journal of preventive medicine. 46(2):122-35.. 2014.
Trajectories of positive aging: observations from the women's health initiative study.. International psychogeriatrics / IPA. :1-12.. 2014.
Efficacy of yoga for vasomotor symptoms: a randomized controlled trial.. Menopause (New York, N.Y.). 21(4):339-46.. 2014.
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.. BMJ (Clinical research ed.). 349:g4164.. 2014.