Johanna W. Lampe

Appointments and Affiliations

Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Cancer Prevention Program
Full Member, Appointed: 2004
University of Washington
School of Public Health and Community Medicine
Epidemiology
Research Professor, Appointed: 2006
Professional Headshot of Johanna W. Lampe

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N., M4-B402
P.O. Box 19024
Seattle, Washington 98109
United States

Degrees

Ph.D., University of Minnesota, Nutrition Sciences, 1990.
B.S., University of Minnesota, Nutrition and Dietetics, 1982.
R.D., University of Minnesota, Nutrition and Dietetics, 1982.

Research Interests

My research interests relate to understanding the mechanisms by which components of diet, particularly constituents of plant foods, alter risk factors for cancer. We use controlled dietary studies and other types of interventions in humans to examine biologic responses to diet and to evaluate biomarkers of dietary exposure. Several of our recent studies have focused on gene-diet interactions in relation to biotransformation enzyme activities. Numerous low-penetrance, high-prevalence genetic polymorphisms in metabolizing enzymes, such as the cytochromes P450 and conjugating enzymes (e.g., glutathione S-transferases, UDP-glucuronosyltransferases), can contribute to interindividual variation in enzyme activities. Many of these enzymes metabolize and inactivate potential carcinogens and cancer-promoting agents. They can also metabolize various compounds in plant foods and can be induced by specific phytochemicals. The relationship between genetic differences in enzyme activities and differences in plant food intake may be an important determinant of cancer susceptibility. Controlled feeding studies in humans are a useful method to examine these interactions.

The Lampe laboratory also investigates the metabolism and activities of isoflavones and lignans (estrogenic compounds found in soybeans and other plant foods). The phytoestrogens, like other plant food constituents, are made more biologically active when they undergo bacterial metabolism in the colon. Differences in colonic bacterial populations and aspects of diet that alter colonic environment influence exposure to potential chemoprotective agents. We are using cross-sectional, intervention, and in vitro studies to determine how dietary factors contribute to these differences in metabolism, whether metabolism can be altered by diet, and what are the biologic implications of these metabolic differences, particularly in relation to colorectal neoplasia. The laboratory also measures phytoestrogen concentrations in biologic samples for several large-scale epidemiologic studies.

Memberships

American Association for Cancer Research
American Dietetic Association
American Society for Nutritional Sciences
Society for Experimental Biology and Medicine

Previous Positions

2002-2006, Research Associate Professor, University of Washington
1999-2004, Associate Member, Fred Hutchinson Cancer Research Center
1999-2002, Research Assistant Professor, University of Washington
1998-1999, Assistant Member, Fred Hutchinson Cancer Research Center
1994-1998, Associate, Fred Hutchinson Cancer Research Center
1993-1994, Research Associate, University of Minnesota, Food, Agricultural & Natural Resource Sciences, College of-Minneapolis/St. Paul, Food Science & Nutrition

Recent Publications

2014
2013
Kantor, ED, Ulrich CM, Owen RW, Schmezer P, Neuhouser ML, Lampe JW, Peters U, Shen DD, Vaughan TL, White E.  2013.  Specialty supplement use and biologic measures of oxidative stress and DNA damage.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Lampe, JW.  2013.  Application of Nutrigenomics Toward Personalized Dietary Recommendations. Menopause-the Journal of the North American Menopause Society. 20:1316-1317. Abstract
2012