Michael LeBlanc

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Full Member, Appointed: 2001
Fred Hutchinson Cancer Research Center
Public Health Sciences
 
Professional Headshot of Michael  LeBlanc

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave N
M3-C102
Seattle, Washington 98109
United States

Contact

Phone: (206) 667-6089
Fax: (206) 667-4408
mleblanc@fhcrc.org
http://mike-leblanc.fhcrc.org/

Degrees

Ph.D., University of Washington, 1989.
M.Math., University of Waterloo, 1985.
B.S., Simon Fraser University, 1984.

Research Interests

My research interests include the design and analysis of clinical trials, methods for exploratory analysis of survival data and adaptive non-parametric regression.

Most of my collaborative research focuses on the design, analysis and conduct of therapeutic clinical trials. I lead the statistical activities related to Phase II and Phase III clinical trials in lymphoma for the Southwest Oncology Group (SWOG). Recently I have been investigating design and analysis methods for targeting patient subgroups appropriate for both Phase II and Phase III clinical trials.

I am interested in the study of adaptive regression methods and their application to data arising from clinical trials. I have developed extensions or alternatives to tree-based methods to yield simple prognostic decision rules in collaboration with Dr. John Crowley (Cancer Research And Biostatistics, CRAB). One example of such methodology is a strategy for constructing prognostic groups based on recursive refinement or peeling algorithms which allow for calibration of the risk group in terms of outcome or fraction of patients in the group.

In addition, I have recently developed an algorithm called Extreme Regression for constructing either high- or low-risk outcome groups in collaboration with Dr. Charles Kooperberg and James Moon (FHCRC). The model leads to a simple inverse regression function which is represented as a Boolean decision rule similar to tree models. However, unlike trees, the new method can control the fraction of subjects identified by the rule.

Some of my other work has included methods for analyzing gene-expression and SNP data. A successful project was Logic Regression, a method which constructs predictors based on Boolean combinations of binary feature variables (led by Charles Kooperberg and originally part of Ingo Ruczinski's dissertation).

I am also currently working on methods that allow specification of genetic structure into the high dimensional regression problem.

Previous Positions

1996-2001, Associate Member, Fred Hutchinson Cancer Research Center
1995-1996, Assistant Member, Fred Hutchinson Cancer Research Center
1990-1995, Assistant Professor, University of Toronto, Preventive Medicine and Biostatistics

Recent Publications

2014
2013
Redman, MW, Goldman BH, LeBlanc M, Schott A, Baker LH.  2013.  Modeling the relationship between progression-free survival and overall survival: the phase II/III trial.. Clinical cancer research : an official journal of the American Association for Cancer Research. 19(10):2646-56. Abstract
2012
Schilsky, RL, Doroshow JH, LeBlanc M, Conley BA.  2012.  Development and use of integral assays in clinical trials.. Clinical cancer research : an official journal of the American Association for Cancer Research. 18(6):1540-6. Abstract
LeBlanc, M, Tangen C.  2012.  Choosing Phase II Endpoints and Designs: Evaluating the Possibilities.. Clinical cancer research : an official journal of the American Association for Cancer Research. 18(8):2130-2. Abstract
2011
2010