Wendy M. Leisenring

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
Clinical Statistics
Member (Primary Appointment), Appointed: 2007
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics
Member (Joint Appointment), Appointed: 2007
University of Washington
School of Public Health and Community Medicine
Biostatistics
Affiliate Professor, Appointed: 2008
Professional Headshot of Wendy M. Leisenring

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N., D5-360
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-4374
Fax: (206) 667-6358
wleisenr@fhcrc.org

Degrees

Sc.D., Harvard University, Biostatistics, 1992.
M.S., Harvard University, Biostatistics, 1990.
A.B., Bryn Mawr College, Mathematics, 1986.

Research Interests

Within the framework of a variety of collaborative and methodological projects, my overall research goals are to ensure that scientific research is carried out that utilizes appropriate statistical methodology. Sometimes this is achieved through application of existing statistical methods and in other instances it involves development of new methodology. My research encompasses several collaborative and methodological subject areas: clinical research related to stem cell transplantation, reproductive epidemiology and developing new statistical methods for the analysis of medical diagnostic test data.

A major focus of my research is collaborative work with clinical investigators who are based in the Center's Clinical Research Division (CRD). CRD is world renown for its pioneering work in stem cell transplantation where the procedure was first used approximately 30 years ago. In collaboration with principal investigators from several large program project grants in the CRD, I carry out the design and analysis of Phase I, II and III clinical trials which aim to further expand and improve our ability to treat patients with a wide range of diseases and prognoses. Over the long history of transplantation at the Center, our group has also developed a large database of patient data that allows us to carry out retrospective analyses to generate hypotheses for future prospective studies.

For patients undergoing stem cell transplantation, infection is a very serious development and more accurate and earlierdetection of disease is an important research topic amongst infectious disease researchers. More globally, diagnostic and screening programs are becoming a large and costly component of our health care system. It is therefore important that research leading to the implementation of new tests be rigorous in determining the accuracy of the tests. A primary goal of my methodological research is to develop statistical methods that allow researchers to answer relevant clinical questions about diagnostic tests. We have described marginal regression methods for the comparison of multiple diagnostic tests and evaluation of covariate impacts on sensitivity and specificity parameters when one or more test outcomes are obtained on each subject studied. Additionally, we developed a new regression methodology for diagnostic likelihood ratios, quantities that describe the degree to which the outcome of a diagnostic test revises the pre-test odds of disease. Most recently, we have developed a statistical test for the comparison of predictive values of diagnostic tests when the data was obtained under paired study designs.

Memberships

American Statistical Association
Biometric Society
Society for Clinical Trials

Honors and Awards

1990-1991, Training Grant Recipient, National Institute of Environmental Health
1989-1991, Harvard University Teaching Fellow,
1988-1990, Training Grant Recipient, National Cancer Institute
1992, Student Prize for Best Paper, ENAR Biometrics Society
1992, Travel Award Recipient, ENAR Biometrics Society
1993, Teratology Society Young Investigators Travel Award,
1994, Best Presentation Award, Society of Toxicology, Risk Assessment Specialty Section

Previous Positions

2002-2008, Affiliate Associate Professor, University of Washington, Department of Biostatistics
2001-2007, Associate Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
2001-2007, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics
1998-2002, Affiliate Assistant Professor, University of Washington, Biostatsitics
1997-2001, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1994-1997, Associate in Clinical Research, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1993-1994, Visiting Investigator, Fred Hutchinson Cancer Research Center

 

Recent Publications

2014
2013
Baker, KS, Chow EJ, Goodman PJ, Leisenring WM, Dietz AC, Perkins JL, Chow L, Sinaiko A, Moran A, Petryk A et al..  2013.  IMPACT OF TREATMENT EXPOSURES ON CARDIOVASCULAR RISK AND INSULIN RESISTANCE IN CHILDHOOD CANCER SURVIVORS.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
2012
Zerr, DM, Boeckh MJ, Delaney C, Martin PJ, Xie H, Adler AL, Huang M-L, Corey L, Leisenring WM.  2012.  HHV-6 Reactivation and Associated Sequelae after Hematopoietic Cell Transplant.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 18(11):1700-1708. Abstract
Veiga, LHS, Bhatti P, Ronckers CM, Sigurdson AJ, Stovall M, Smith SA, Weathers R, Leisenring WM, Mertens AC, Hammond S et al..  2012.  Chemotherapy and Thyroid Cancer Risk: a Report from the Childhood Cancer Survivor Study.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(1):92-101. Abstract
2011
Kirchhoff, AC, Krull KR, Ness KK, Armstrong GT, Park ER, Stovall M, Robison LL, Leisenring WM.  2011.  Physical, Mental, and Neurocognitive Status and Employment Outcomes in the Childhood Cancer Survivor Study Cohort.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(9):1838-49. Abstract