Wendy M. Leisenring
Sc.D., Harvard University, Biostatistics, 1992.
M.S., Harvard University, Biostatistics, 1990.
A.B., Bryn Mawr College, Mathematics, 1986.
Within the framework of a variety of collaborative and methodological projects, my overall research goals are to ensure that scientific research is carried out that utilizes appropriate statistical methodology. Sometimes this is achieved through application of existing statistical methods and in other instances it involves development of new methodology. My research encompasses several collaborative and methodological subject areas: clinical research related to stem cell transplantation, reproductive epidemiology and developing new statistical methods for the analysis of medical diagnostic test data.
A major focus of my research is collaborative work with clinical investigators who are based in the Center's Clinical Research Division (CRD). CRD is world renown for its pioneering work in stem cell transplantation where the procedure was first used approximately 30 years ago. In collaboration with principal investigators from several large program project grants in the CRD, I carry out the design and analysis of Phase I, II and III clinical trials which aim to further expand and improve our ability to treat patients with a wide range of diseases and prognoses. Over the long history of transplantation at the Center, our group has also developed a large database of patient data that allows us to carry out retrospective analyses to generate hypotheses for future prospective studies.
For patients undergoing stem cell transplantation, infection is a very serious development and more accurate and earlierdetection of disease is an important research topic amongst infectious disease researchers. More globally, diagnostic and screening programs are becoming a large and costly component of our health care system. It is therefore important that research leading to the implementation of new tests be rigorous in determining the accuracy of the tests. A primary goal of my methodological research is to develop statistical methods that allow researchers to answer relevant clinical questions about diagnostic tests. We have described marginal regression methods for the comparison of multiple diagnostic tests and evaluation of covariate impacts on sensitivity and specificity parameters when one or more test outcomes are obtained on each subject studied. Additionally, we developed a new regression methodology for diagnostic likelihood ratios, quantities that describe the degree to which the outcome of a diagnostic test revises the pre-test odds of disease. Most recently, we have developed a statistical test for the comparison of predictive values of diagnostic tests when the data was obtained under paired study designs.
American Statistical Association
Society for Clinical Trials
Honors and Awards
1990-1991, Training Grant Recipient, National Institute of Environmental Health
1989-1991, Harvard University Teaching Fellow,
1988-1990, Training Grant Recipient, National Cancer Institute
1992, Student Prize for Best Paper, ENAR Biometrics Society
1992, Travel Award Recipient, ENAR Biometrics Society
1993, Teratology Society Young Investigators Travel Award,
1994, Best Presentation Award, Society of Toxicology, Risk Assessment Specialty Section
2002-2008, Affiliate Associate Professor, University of Washington, Department of Biostatistics
2001-2007, Associate Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
2001-2007, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics
1998-2002, Affiliate Assistant Professor, University of Washington, Biostatsitics
1997-2001, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1994-1997, Associate in Clinical Research, Fred Hutchinson Cancer Research Center, Clinical Research Division, Clinical Statistics
1993-1994, Visiting Investigator, Fred Hutchinson Cancer Research Center
Parainfluenza Virus Lower Respiratory Tract Disease after Hematopoietic Cell Transplantation: Viral Detection in the Lung Predicts Outcome.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 2014.
Influence of conventional cardiovascular risk factors and lifestyle characteristics on cardiovascular disease after hematopoietic cell transplantation.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 32(3):191-8.. 2014.
Late Cardiovascular Complications after Hematopoietic Cell Transplantation.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2014.
Recurrent Stroke Risk in Childhood Cancer Survivors. Neuro-Oncology. 15:230–230.. 2013.
IMPACT OF TREATMENT EXPOSURES ON CARDIOVASCULAR RISK AND INSULIN RESISTANCE IN CHILDHOOD CANCER SURVIVORS.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2013.
Outcome of Respiratory Syncytial Virus Lower Respiratory Tract Disease in Hematopoietic Cell Transplant Recipients Receiving Aerosolized Ribavirin: Significance of Stem Cell Source and Oxygen Requirement.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.. 2013.
Absolute risk prediction of second primary thyroid cancer among 5-year survivors of childhood cancer.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 31(1):119-27.. 2013.
HHV-6 Reactivation and Associated Sequelae after Hematopoietic Cell Transplant.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 18(11):1700-1708.. 2012.
Cardiovascular Risk and Insulin Resistance in Childhood Cancer Survivors.. The Journal of pediatrics. 160(3):494-499.. 2012.
Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort.. Pediatric blood & cancer. 59(1):126-132.. 2012.
Chemotherapy and Thyroid Cancer Risk: a Report from the Childhood Cancer Survivor Study.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(1):92-101.. 2012.
Development of a comprehensive health-related needs assessment for adult survivors of childhood cancer.. Journal of cancer survivorship : research and practice.. 2012.
Physical, Mental, and Neurocognitive Status and Employment Outcomes in the Childhood Cancer Survivor Study Cohort.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(9):1838-49.. 2011.
Semiparametric transformation models for joint analysis of multivariate recurrent and terminal events.. Statistics in medicine. 30(25):3010-3023.. 2011.
Decreased fertility among female childhood cancer survivors who received 22-27 Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study.. Fertility and sterility. 95(6):1922-7,1927.e1.. 2011.
An international comparison of current strategies to prevent herpesvirus and fungal infections in hematopoietic cell transplant recipients.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(5):664-73.. 2011.
Associations between polymorphisms in glucuronidation and sulfation enzymes and sex steroid concentrations in premenopausal women in the United States.. The Journal of steroid biochemistry and molecular biology. 124(1-2):10-8.. 2011.