Michael L. Linenberger

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research
Associate Member
 
Seattle Cancer Care Alliance
Medical Director, Apheresis and Cellular Therapy
 
University of Washington
School of Medicine
Robert & Phyllis Henigson Professor of Hematology
Program Director, Hematology/Oncology Fellowship
Professional Headshot of Michael L. Linenberger

Mailing Address

Fred Hutchinson Cancer Research Center (D5280)
1100 Fairview Avenue N.
Seattle, WA 98109

Contact

Phone: 206-667-5021
Fax: 206-667-5899
linen@u.washington.edu

Degrees

M.D., University of Kansas, 1982.
B.S., University of Kansas, 1978.

Research Interests

Current research interests include studies of mechanisms of drug resistance in acute myeloid leukemia (AML), including drug transporter mechanisms active against antibody-directed therapy. Other interests include optimization of methods for stem cell procurement, therapeutic apheresis approaches for post-transplant graft-versus-host disease, and cellular therapy applications relevant to hematopoietic stem cell transplantation.

Additional Experience

Clinical Interests:
Therapeutic Apheresis;
Marrow and peripheral blood tem cell procurement;
AML treatment with antibody-based agents;
Hypercoagulable disorders;
Iron overload disorders;
Porphyrias;
Benign and malignant hematologic disorders.

Prior Research Activity:
Mechanisms of retroviral-mediated hematopoietic suppression and leukemogenesis.

Future Research

We are working to apply our knowledge of drug resistance mechanisms against antibody-based therapies for AML toward conducting clinical trials using drug resistance modulating agents.

We are working to develop clinical protocols to study the mechanisms and therapeutic efficacy of extracorporeal photochemotherapy for graft-versus-host disease.

Memberships

Alpha Chi Sigma
Alpha Omega Alpha
American Association of Blood Banks
American College of Physicians
American Society for Apheresis
American Society of Hematology
International Society for Cellular Therapy

Previous Positions

1993-2000, Assistant Professor, University of Washington, School of Medicine, Medicine, Hematology
1989-1993 University of Washington, Hematology, Acting Instructor

Recent Publications

2015
2014
2013
2012
2009
Valji, K, Linenberger ML.  2009.  Chasing clot: thrombophilic states and the interventionalist.. Journal of vascular and interventional radiology : JVIR. 20(11):1403-16;quiz1417. Abstract
2008