Michael L. Linenberger

Appointments and Affiliations

Fred Hutchinson Cancer Research Center
Clinical Research
Associate Member, Appointed: 2001
Seattle Cancer Care Alliance
Blood and Blood Component Services
Director, Appointed: 2001
University of Washington
School of Medicine
Associate Professor, Appointed: 2000
Professional Headshot of Michael L. Linenberger

Mailing Address

Seattle Cancer Care Alliance
825 Eastlake Ave. E. (G6-800)
P. O. Box 19023
Seattle, Washington 98109
United States


Phone: (206) 288-2038
Fax: (206) 288-1130


M.D., University of Kansas, 1982.
B.S., University of Kansas, 1978.

Research Interests

Current research interests include studies of mechanisms of drug resistance in acute myeloid leukemia (AML), including drug transporter mechanisms active against antibody-directed therapy. Other interests include optimization of methods for stem cell procurement, therapeutic apheresis approaches for post-transplant graft-versus-host disease, and cellular therapy applications relevant to hematopoietic stem cell transplantation.

Additional Experience

Clinical Interests:
Therapeutic Apheresis;
Marrow and peripheral blood tem cell procurement;
AML treatment with antibody-based agents;
Hypercoagulable disorders;
Iron overload disorders;
Benign and malignant hematologic disorders.

Prior Research Activity:
Mechanisms of retroviral-mediated hematopoietic suppression and leukemogenesis.

Future Research

We are working to apply our knowledge of drug resistance mechanisms against antibody-based therapies for AML toward conducting clinical trials using drug resistance modulating agents.

We are working to develop clinical protocols to study the mechanisms and therapeutic efficacy of extracorporeal photochemotherapy for graft-versus-host disease.


Alpha Chi Sigma
Alpha Omega Alpha
American Association of Blood Banks
American College of Physicians
American Society for Apheresis
American Society of Hematology
International Society for Cellular Therapy

Previous Positions

1993-2000, Assistant Professor, University of Washington, School of Medicine, Medicine, Hematology
1989-1993 University of Washington, Hematology, Acting Instructor

Recent Publications

Valji, K, Linenberger ML.  2009.  Chasing clot: thrombophilic states and the interventionalist.. Journal of vascular and interventional radiology : JVIR. 20(11):1403-16;quiz1417. Abstract