Georg Luebeck

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Computational Biology
Member, Appointed: 2013
University of Washington
School of Public Health and Community Medicine
Biostatistics
Affiliate Associate Professor, Appointed: 2007
Professional Headshot of Georg  Luebeck

Mailing Address

1100 Fairview Ave. N. M1-B514
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-4282
Mobile: (253) 229-4483
gluebeck@fhcrc.org

Degrees

Ph.D., University of Washington, Physics, 1986.
M.S., University of Washington, Physics, 1983.
Diplom in Physik (equiv. MS), University of Tuebingen, 1982.

Research Interests

My lab focuses primarily on the development of biomathematical descriptions of carcinogenesis, the identification and characterization of relevant spatio-temporal scales, and their impact on cancer incidence. From these descriptions we derive methods for the quantitative analysis of both experimental and epidemiological data, including data on precursor lesions from screening studies. The ultimate goal is to being able to model/optimize the benefits of cancer screening, prevention, and intervention - based on a biological description of the natural history of cancer.

Highlights of recent activities: investigation of mathematical and statistical properties of the Multistage Clonal Expansion (MSCE) carcinogenesis model, derivation of hazard functions (used to estimate the age-specific cancer incidence/mortality), development of fast algorithms for the computation of hazard and survival functions for constant and piecewise constant parameters, exploration of parameter identifiability, stable reparameterizations. We are also working on model extensions that capture more biological detail of neoplastic progression, including the spatial organization of normal and neoplastic tissues.

Highlights of past activities: radiation-induced carcinogenesis, multistage carcinogenesis as a framework to model the benefits of screening, interventions and cancer prevention strategies, multiscale modeling of neoplastic progression in colon and in Barrett's esophagus, stochastic modeling of DNA methylation and its somatic inheritance. These activities include the development of new computational approaches, high-performance (parallel) computing, hierarchical Bayesian models, and Markov Chain Monte Carlo (MCMC) techniques.

Additional Experience

Much of the computer code we develop is in High Performance Fortran (HPF), which allows for parallelization of code on multiprocessor systems. We have set up two Beowulf clusters (the first at FHCRC!) running under Linux with dynamic load balancing using MOSIX. This configuration has been essential for the analysis of very large data sets.

I have extensive experience in scientific and statistical computing. My preferred programming environment for prototyping code and for statistical problems is R (a clone of S). I am author of the Bhat package, a set of tools written in F90 and R for the exploration of general likelihood functions (found at http://cran.r-project.org ).

Future Research

Computational and Theoretical Biology. Development of a Center for Experimental and Mathematical Oncology (CEMO) jointly with Kristin Swanson (UW Pathology and Applied Mathematics).

Further topics of interest are:

Epigenetics and DNA Methylation. See our publication in JTB on the "Dynamics, Stability and Inheritance of somatic DNA Methylation Imprints."

Phylogenetics. In collaboration with Dr. Li Hsu (FHCRC), I have developed R-based software to explore SNP/LOH data and to construct maximum weight spanning trees based on Desper's algorithm. We are currently working on stochastic extensions of this approach.

Industry

Our mathematical models of carcinogenesis are useful tools for biologically informed cancer risk prediction and quantitative risk assessment of environmental carcinogens.

Languages

Reading, Writing, Speaking

English: Fluent, Fluent, Fluent
German: Fluent, Fluent, Fluent
French: Functional, Basic, Basic

Previous Positions

2006-2013, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division
2002-2006, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division
1993-2002, Senior Staff Scientist, Fred Hutchinson Cancer Research Center, Public Health Sciences Division
1988-1993, Staff Scientist, Fred Hutchinson Cancer Research Center, Public Health Sciences Division
1986-1988, Postdoctoral Fellow, Niels Bohr Institut, Copenhagen

 

Recent Publications

2014
Kong, CY, Kroep S, Curtius K, Hazelton WD, Jeon J, Meza R, Heberle C, Miller M, Choi SE, Lansdorp-Vogelaar I et al..  2014.  Exploring the Recent Trend in Esophageal Adenocarcinoma Incidence and Mortality Using Comparative Simulation Modeling.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
2013
2012
2011
2010
2008
Chao, DL, Eck TJ, Brash DE, Maley CC, Luebeck EG.  2008.  Preneoplastic lesion growth driven by the death of adjacent normal stem cells.. Proceedings of the National Academy of Sciences of the United States of America. 105(39):15034-9. Abstract
Meza, R, Jeon J, Moolgavkar SH, Luebeck EG.  2008.  Age-specific incidence of cancer: Phases, transitions, and biological implications.. Proceedings of the National Academy of Sciences of the United States of America. 105(42):16284-9. Abstract
Luebeck, EG, Moolgavkar SH, Liu AY, Boynton A, Ulrich CM.  2008.  Does folic acid supplementation prevent or promote colorectal cancer? Results from model-based predictions. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 17(6):1360-7. Abstract
2006