Margaret M. Madeleine

Appointments and Affiliations
 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Program in Epidemiology
Assistant Member, Appointed: 2008
University of Washington
School of Public Health and Community Medicine
Epidemiology
Assistant Research Professor
 Professional Headshot of Margaret M. Madeleine

Mailing Address

1100 Fairview Ave. N
M4-C308
Seattle, Washington 98109-1024
United States

Degrees

Ph.D., University of Washington, Epidemiology, 1996.
M.P.H., Yale University, Epidemiology, 1991.

Research Interests

My major research focus is on the molecular epidemiology of pathogens and our immune response to them that may be associated with cancer development and prognosis. I am also interested in the role that chronic subclinical immune disregulation (such as occurs with age, obesity, physical inactivity, hormone fluctuation, and UV exposure) and sex differences may play in carcinogenesis.

Honors and Awards

2011, Team Science Award, American Association of Cancer Research

Funding

  • National Cancer Institute: Inflammation Pathways in Breast Cancer, 2007 to 2011.
  • National Cancer Institute: Skin Cancer after Organ Transplant, 2007 to 2012.

 

Recent Publications

2013
Resler, AJ, Malone KE, Johnson LG, Malkki M, Petersdorf EW, McKnight B, Madeleine MM.  2013.  Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.. BMC cancer. 13:219. Abstract
2012
De Roos, AJ, Mirick DK, Edlefsen KL, LaCroix AZ, Kopecky KJ, Madeleine MM, Magpantay L, Martínez-Maza O.  2012.  Markers of B-Cell Activation in Relation to Risk of Non-Hodgkin Lymphoma.. Cancer research. Abstract
Stott-Miller, M, Chen C, Doody DR, Carter JL, Galloway DA, Madeleine MM, Schwartz SM.  2012.  A history of allergies is associated with reduced risk of oral squamous cell carcinoma.. Cancer causes & control : CCC. Abstract
Madeleine, MM, Johnson LG, Daling JR, Schwartz SM, Carter JJ, Berg D, Nelson K, Davis CL, Galloway DA.  2012.  Cohort Profile: The Skin Cancer After Organ Transplant Study.. International journal of epidemiology. Abstract
Guo, F, Liu Y, Wang X, He Z, Weiss NS, Madeleine MM, Liu F, Tian X, Song Y, Pan Y et al..  2012.  Human Papillomavirus Infection and Esophageal Squamous Cell Carcinoma: A Case-Control Study.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Bodelon, C, Madeleine MM, Johnson LG, Du Q, Malkki M, Petersdorf EW, Schwartz SM.  2012.  Genetic variation in CD83 and risks of cervical and vulvar cancers: A population-based case-control study.. Gynecologic oncology. 124(3):525-528. Abstract
Hussain, SK, Madeleine MM, Johnson LG, Du Q, Galloway DA, Daling JR, Malkki M, Petersdorf EW, Schwartz SM.  2012.  Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: A hybrid case-parent triad and case-control study.. International journal of cancer. Journal international du cancer. Abstract
2011
Madeleine, MM, Johnson LG, Malkki M, Resler AJ, Petersdorf EW, McKnight B, Malone KE.  2011.  Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.. Breast cancer research and treatment. 129(3):887-899. Abstract
Burnett-Hartman, AN, Newcomb PA, Mandelson MT, Galloway DA, Madeleine MM, Wurscher MA, Carter JJ, Makar KW, Potter JD, Schwartz SM.  2011.  No Evidence for Human Papillomavirus in the Etiology of Colorectal Polyps.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(10):2288-97. Abstract
Engels, EA, Pfeiffer RM, Fraumeni JF, Kasiske BL, Israni AK, Snyder JJ, Wolfe RA, Goodrich NP, Bayakly RA, Clarke CA et al..  2011.  Spectrum of cancer risk among US solid organ transplant recipients.. JAMA : the journal of the American Medical Association. 306(17):1891-901. Abstract
Johnson, LG, Schwartz SM, Malkki M, Du Q, Petersdorf EW, Galloway DA, Madeleine MM.  2011.  Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(1):199-207. Abstract
Paulson, KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR et al..  2011.  Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 29(12):1539-46. Abstract
Guthrie, KA, Gammill HS, Madeleine MM, Dugowson CE, Nelson JL.  2011.  Parity and HLA alleles in risk of rheumatoid arthritis.. Chimerism (Print). 2(1):11-15. Abstract
2010
Paulson, KG, Carter JJ, Johnson LG, Cahill KW, Iyer JG, Schrama D, Becker JC, Madeleine MM, Nghiem P, Galloway DA.  2010.  Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.. Cancer research. 70(21):8388-97. Abstract
2009
Carter, JJ, Paulson KG, Wipf GC, Miranda D, Madeleine MM, Johnson LG, Lemos BD, Lee S, Warcola AH, Iyer JG et al..  2009.  Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma.. Journal of the National Cancer Institute. 101(21):1510-22. Abstract
Bodelon, C, Madeleine MM, Voigt LF, Weiss NS.  2009.  Is the incidence of invasive vulvar cancer increasing in the United States? Cancer causes & control : CCC. 20(9):1779-82. Abstract
Lanoy, E, Dores GM, Madeleine MM, Toro JR, Fraumeni JF, Engels EA.  2009.  Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States.. AIDS (London, England). 23(3):385-93. Abstract
Maley, SN, Schwartz SM, Johnson LG, Malkki M, Du Q, Daling JR, Li SS, Zhao LP, Petersdorf EW, Madeleine MM.  2009.  Genetic variation in CXCL12 and risk of cervical carcinoma: a population-based case-control study.. International journal of immunogenetics. 36(6):367-75. Abstract
Chaturvedi, AK, Madeleine MM, Biggar RJ, Engels EA.  2009.  Risk of human papillomavirus-associated cancers among persons with AIDS.. Journal of the National Cancer Institute. 101(16):1120-30. Abstract
De Vuyst, H, Clifford GM, Nascimento MC, Madeleine MM, Franceschi S.  2009.  Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis.. International journal of cancer. Journal international du cancer. 124(7):1626-36. Abstract
Edelstein, ZR, Madeleine MM, Hughes JP, Johnson LG, Schwartz SM, Galloway DA, Carter JJ, Koutsky LA.  2009.  Age of diagnosis of squamous cell cervical carcinoma and early sexual experience.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(4):1070-6. Abstract
2008
Madeleine, MM, Johnson LG, Smith AG, Hansen JA, Nisperos BB, Li S, Zhao LP, Daling JR, Schwartz SM, Galloway DA.  2008.  Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk.. Cancer research. 68(9):3532-9. Abstract
Hussain, SK, Madeleine MM, Johnson LG, Du Q, Malkki M, Wilkerson H-W, Farin FM, Carter JJ, Galloway DA, Daling JR et al..  2008.  Cervical and vulvar cancer risk in relation to the joint effects of cigarette smoking and genetic variation in interleukin 2.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 17(7):1790-9. Abstract
Insinga, RP, Liaw K-L, Johnson LG, Madeleine MM.  2008.  A systematic review of the prevalence and attribution of human papillomavirus types among cervical, vaginal, and vulvar precancers and cancers in the United States.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 17(7):1611-22. Abstract