Kathleen E. Malone
Ph.D., University of Washington, Epidemiology, 1993.
M.P.H., Yale University, Epidemiology, 1984.
B.S.W., Temple University, Social Work, 1978.
The primary focus of my research is on the epidemiology of breast cancer, with foci on the etiologic and genetic determinants of developing breast cancer as well as predictors of outcomes after breast cancer, particularly second primaries, recurrences, and survival. Most of this research is interdisciplinary, links the strengths of large population-based epidemiologic studies with molecular genetics, research pathology, biostatistics, oncology, and other disciplines, and involves a large number of colleagues and staff. Investigations include studies of the risk of developing breast cancer in relation to various genetic pathways ranging from rare but high risk mutations in BRCA1/2 to more common variants in hormone-mediating genes and immune-related genes, studies of a wide spectrum of risk factors including some that are potentially modifiable, and studies of prognosis in relation to patient exposures, therapies and novel markers in tumors. The ultimate goal of these studies is to improve strategies for (1) identifying those at higher (lower) risk of developing breast cancer, and (2) reducing the risk of breast cancer, and similarly, (3) identifying those at higher (lower) risk of disease progression or second primary breast cancer, and (4) reducing risk of adverse outcomes after breast cancer.
American Association for Cancer Research
2010-2011, Co-Program Head, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Program in Epidemiology
2002-2007, Associate Professor (Research), University of Washington, School of Public Health and Community Medicine, Department of Epidemiology
2000-2008, Associate Program Head, Fred Hutchinson Cancer Research Center, Program in Breast Cancer Research
2000-2006, Associate Member, Fred Hutchinson Cancer Research Center, Program in Epidemiology, Division of Public Health Sciences
2000-2010, Associate Program Head, Fred Hutchinson Cancer Research Center, Program in Epidemiology, Division of Public Health Sciences
1998-2000, Assistant Member, Fred Hutchinson Cancer Research Center, Epidemiology, Public Health Sciences
1998-2002, Assistant Professor (Research), University of Washington, School of Public Health and Community Medicine, Epidemiology
1994-1998, Affiliate Instructor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1993-1998, Associate, Fred Hutchinson Cancer Research Center, Epidemiology, Public Health Sciences
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.. Nature genetics. 47(4):373-80.. 2015.
Oral contraceptives and breast cancer risk overall and by molecular subtype among young women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
Adherence to oral diabetes medications and glycemic control during and following breast cancer treatment.. Pharmacoepidemiology and drug safety.. 2014.
A Genome-wide Association Study of Early-onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
The risk of breast cancer associated with specific patterns of migraine history.. Cancer causes & control : CCC. 25(12):1707-15.. 2014.
Recent Oral Contraceptive Use by Formulation and Breast Cancer Risk among Women 20 to 49 Years of Age.. Cancer research. 74(15):4078-89.. 2014.
Use of menopausal hormone therapy and risk of ductal and lobular breast cancer among women 55-74 years of age.. Breast cancer research and treatment.. 2014.
Antihypertensive medications and breast cancer risk-reply.. JAMA internal medicine. 174(4):641.. 2014.
Quantitative measures of estrogen receptor expression in relation to breast cancer-specific mortality risk among white women and black women.. Breast cancer research : BCR. 15(5):R90.. 2013.
Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: A WECARE Study Report.. European journal of cancer (Oxford, England : 1990). 49(14):2979-2985.. 2013.
Long-Term Statin Use and Risk of Ductal and Lobular Breast Cancer among Women 55 to 74 Years of Age.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(9):1529-37.. 2013.
Reproductive factors and risk of estrogen receptor positive, triple-negative, and HER2-neu overexpressing breast cancer among women 20-44 years of age.. Breast cancer research and treatment. 137(2):579-87.. 2013.
Use of Antihypertensive Medications and Breast Cancer Risk Among Women Aged 55 to 74 Years.. JAMA internal medicine.. 2013.
Common variants in genes coding for chemotherapy metabolizing enzymes, transporters, and targets: a case-control study of contralateral breast cancer risk in the WECARE Study.. Cancer causes & control : CCC. 24(8):1605-14.. 2013.
Variants in tamoxifen metabolizing genes: a case-control study of contralateral breast cancer risk in the WECARE study.. International journal of molecular epidemiology and genetics. 4(1):35-48.. 2013.
Estrogen receptor, progesterone receptor, and HER2-neu expression in first primary breast cancers and risk of second primary contralateral breast cancer.. Breast cancer research and treatment. 135(3):849-55.. 2012.
Examination of ancestral informative markers and self-reported race with tumor characteristics of breast cancer among black and white women.. Breast cancer research and treatment.. 2012.
Breast Density, Body Mass Index, and Risk of Tumor Marker-Defined Subtypes of Breast Cancer.. Annals of epidemiology. 22(5):340-348.. 2012.
Estrogen-related genes and their contribution to racial differences in breast cancer risk.. Cancer causes & control : CCC. 23(5):671-81.. 2012.