George B. McDonald
Fellowship, University of Washington, Gastroenterology, 1975.
Residency, University of Washington, Medicine, 1969.
M.D., Washington University in St. Louis, Medicine, 1967.
Dr. McDonald's research over the last 40 years has been focused on gastrointestinal and hepatobiliary problems in patients with cancer, with an emphasis on complications of and outcomes following hematopoietic cell transplantation. Specific topics have included graft-vs-host disease, sinusoidal obstruction syndrome, viral hepatitis, biliary disease, and infections of the gastrointestinal tract and liver. He formerly directed the Cytokine Analysis Laboratory, a shared resource for investigators at the FHCRC, University of Washington, and Seattle Childrens' Hospital. In collaboration with investigators in the Pharmacology Section, he has examined the pharmacokinetics of chemotherapy drugs used in transplantation, research that has led to methods of limiting toxicity. In 1998, he published a paper describing patients with both leukemia and Crohn’s Disease whose leukemia was cured by bone marrow transplants for leukemia, but whose Crohn’s Disease also disappeared. This observation formed the basis for his current research protocol, the Crohn’s Allogeneic Transplant Study (CATS), described below.
The Crohn’s Allogeneic Transplant Study is more completely described in the website www.CATS-FHCRC.org. This protocol will enroll 12 patients whose Crohn’s Disease has failed to respond to any of the known therapies, whose symptoms are persistent or whose disease has returned after intestinal surgery. This study is partially funded by the Eli and Edythe Broad Foundation’s Medical Research Program, conducted under the auspices of a U.S. Food and Drug Administration Investigational New Drug application, and monitored by a Data Safety and Monitoring Board and by the Fred Hutchinson Cancer Research Center’s Institutional Review Office.
Ongoing clinical research that aims at reducing complications of hematopoietic cell transplantation and improving survival include the following projects:
Alpha Omega Alpha
American Association for the Study of Liver Diseases
American Gastroenterological Association
1967-1969 Resident in Medicine, University of Washington, Seattle, WA