M.D., New York Medical College, 1989.
Ph.D., University of Washington, Epidemiology, 1982.
Prevention of new and recurrent breast and other cancer through physical activity, diet and chemoprevention.
Dr. McTiernan's research focuses on identifying ways to prevent new or recurrent cancer with a particular focus on weight control, physical activity, and chemoprevention. She is Principal Investigator of the Seattle TREC Center investigating mechanisms of energy balance and cancer prevention. She leads over twenty five scientists in transdisciplinary reasearch to elucidate the pathways linking components of energy balance to the cancer process. The five projects and four cores incorporate several different study designs, with contributions of scientists from medicine, cell biology, animal models, immunology, biostatistics, mathematics, exercise physiology, and behavioral science.
Dr. McTiernan is also Principal Investigator of a randomized controlled clinical trial of a one-year aerobic exercise intervention to compare the effects over one year of two lifestyle interventions in 503 postmenopausal women: (1) a moderate-intensity aerobic exercise intervention, and (2) a reduced-calorie diet plus moderate-intensity aerobic exercise intervention. She is Principal Investigator of the Seattle site of Health, Eating, Activity, and Lifestyle (HEAL) Study, which is assessing associations among anthropometrics, fat mass amount and distribution, endogenous sex and metabolic hormones, diet, and physical activity on prognostic factors in breast cancer patients. Dr. McTiernan is Principal Investigator of the Seattle site of the ExCel trial which is testing the effect of exemestane, an aromatase inhibitor, on breast cancer prevention, and she leads a randomized clinical trial testing aspirin effect on breast cancer biomarkers.
Previously she has conducted a randomized controlled clinical trial of a one-year aerobic exercise intervention vs. stretch control in 173 postmenopausal women. The primary aim of this study was to assess the effect of exercise on endogenous sex hormones that have been associated with increased risk for breast cancer. Ongoing ancillary studies test the effect of aerobic exercise on immune function and other biomarkers of breast cancer risk.
She is also been Principal Investigator of a randomized clinical trial to test the effect of a one-year aerobic exercise intervention vs. control on colorectal cell proliferation, apoptosis, and prostaglandin content, and on other biomarkers of colon cancer risk in 200 men and women with adenomatous colon polyps.
Dr. McTiernan was a co-Investigator in the Women's Health Initiative (WHI), and directed clinical outcomes efforts at the WHI Clinical Coordinating Center. She has conducted an analysis of physical activity and breast cancer incidence in the WHI Observational Study cohort of over 90,000 women and has collaborated on many additional analyses.
Dr. McTiernan has considerable experience with recruitment, retention, adherence, and endpoints in large-scale medication clinical trials (e.g. the Women's Health Initiative hormone therapy and calcium/vitamin D trials). She has expertise in Women's Health issues. She is co-investigator of the Seattle STAR trial, hence has experience with clinical trials using SERMS.
University of Washington Residency Training Internal Medicine 1992
American College of Epidemiology
American Society of Preventive Oncology
Society for Epidemiologic Research
Effects of physical activity on melatonin levels in previously sedentary men and women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
Change in Peripheral Blood Leukocyte Telomere Length and Mortality in Breast Cancer Survivors.. Journal of the National Cancer Institute.. 2014.
Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial.. The American journal of clinical nutrition.. 2014.
No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women.. Obesity (Silver Spring, Md.).. 2014.
Aspirin and Serum Estrogens in Postmenopausal Women: a Randomized Controlled Clinical Trial.. Cancer prevention research (Philadelphia, Pa.).. 2014.
Effect of a 12-month Exercise Intervention on Serum Biomarkers of Angiogenesis in Postmenopausal Women: a randomized controlled trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2014.
Plasma polychlorinated biphenyl concentrations and immune function in postmenopausal women.. Environmental research. 131C:174-180.. 2014.
Genetic variation in CYP19A1, daily estrogen level and mammographic density in premenopausal women. European Journal of Cancer. 50:S74-S75.. 2014.
Predicting Adherence of Adults to a 12-Month Exercise Intervention.. Journal of physical activity & health.. 2013.
Lower Skin Cancer Risk in Women with Higher Body Mass Index: The Women's Health Initiative Observational Study.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2013.
Longitudinal Changes in IGF-I and IGFBP-3, and Mammographic Density among Postmenopausal Women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(11):2116-20.. 2013.
Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women.. Obesity (Silver Spring, Md.).. 2013.
Long-Term Physical Activity Trends in Breast Cancer Survivors.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2013.
Predictors of Adherence to a 26-Week Viniyoga Intervention Among Post-Treatment Breast Cancer Survivors.. Journal of alternative and complementary medicine (New York, N.Y.).. 2013.
Walking speed, physical activity, and breast cancer in postmenopausal women.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP).. 2013.
Association between sex hormones, glucose homeostasis, adipokines, and inflammatory markers and mammographic density among postmenopausal women.. Breast cancer research and treatment. 139(1):255-65.. 2013.
Increases in physical activity may affect quality of life differently in men and women: the PACE project.. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation.. 2013.
Gene Expression Changes in Adipose Tissue with Diet- and/or Exercise-Induced Weight Loss.. Cancer prevention research (Philadelphia, Pa.). 6(3):217-31.. 2013.
Sedentary behavior, health-related quality of life, and fatigue among breast cancer survivors.. Journal of physical activity & health. 10(3):350-8.. 2013.
Weight, inflammation, cancer-related symptoms and health-related quality of life among breast cancer survivors.. Breast cancer research and treatment.. 2013.
Diabetes, metformin use, and colorectal cancer survival in postmenopausal women.. Cancer epidemiology.. 2013.