Anne McTiernan

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Epidemiology
Member
University of Washington
School of Medicine
Epidemiology and Geriatrics
Research Professor
Professional Headshot of Anne  McTiernan

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
M4-B874
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-7979
Fax: (206) 667-4787
amctiern@fhcrc.org

Degrees

M.D., New York Medical College, 1989.
Ph.D., University of Washington, Epidemiology, 1982.

Research Interests

Prevention of new and recurrent breast and other cancer through physical activity, diet and chemoprevention.

Dr. McTiernan's research focuses on identifying ways to prevent new or recurrent cancer with a particular focus on weight control, physical activity, and chemoprevention. She is Principal Investigator of the Seattle TREC Center investigating mechanisms of energy balance and cancer prevention. She leads over twenty five scientists in transdisciplinary reasearch to elucidate the pathways linking components of energy balance to the cancer process. The five projects and four cores incorporate several different study designs, with contributions of scientists from medicine, cell biology, animal models, immunology, biostatistics, mathematics, exercise physiology, and behavioral science.

Dr. McTiernan is also Principal Investigator of a randomized controlled clinical trial of a one-year aerobic exercise intervention to compare the effects over one year of two lifestyle interventions in 503 postmenopausal women: (1) a moderate-intensity aerobic exercise intervention, and (2) a reduced-calorie diet plus moderate-intensity aerobic exercise intervention. She is Principal Investigator of the Seattle site of Health, Eating, Activity, and Lifestyle (HEAL) Study, which is assessing associations among anthropometrics, fat mass amount and distribution, endogenous sex and metabolic hormones, diet, and physical activity on prognostic factors in breast cancer patients. Dr. McTiernan is Principal Investigator of the Seattle site of the ExCel trial which is testing the effect of exemestane, an aromatase inhibitor, on breast cancer prevention, and she leads a randomized clinical trial testing aspirin effect on breast cancer biomarkers.

Previously she has conducted a randomized controlled clinical trial of a one-year aerobic exercise intervention vs. stretch control in 173 postmenopausal women. The primary aim of this study was to assess the effect of exercise on endogenous sex hormones that have been associated with increased risk for breast cancer. Ongoing ancillary studies test the effect of aerobic exercise on immune function and other biomarkers of breast cancer risk.

She is also been Principal Investigator of a randomized clinical trial to test the effect of a one-year aerobic exercise intervention vs. control on colorectal cell proliferation, apoptosis, and prostaglandin content, and on other biomarkers of colon cancer risk in 200 men and women with adenomatous colon polyps.

Dr. McTiernan was a co-Investigator in the Women's Health Initiative (WHI), and directed clinical outcomes efforts at the WHI Clinical Coordinating Center. She has conducted an analysis of physical activity and breast cancer incidence in the WHI Observational Study cohort of over 90,000 women and has collaborated on many additional analyses.

Additional Experience

Dr. McTiernan has considerable experience with recruitment, retention, adherence, and endpoints in large-scale medication clinical trials (e.g. the Women's Health Initiative hormone therapy and calcium/vitamin D trials). She has expertise in Women's Health issues. She is co-investigator of the Seattle STAR trial, hence has experience with clinical trials using SERMS.

University of Washington Residency Training Internal Medicine 1992

Memberships

American College of Epidemiology
American Society of Preventive Oncology
Society for Epidemiologic Research

 

Recent Publications

2014
Thrift, AP, Xiao L, Patel SR, Tworoger SS, McTiernan A, Duggan C.  2014.  Effects of physical activity on melatonin levels in previously sedentary men and women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Duggan, C, Xiao L, Wang C-Y, McTiernan A.  2014.  Effect of a 12-month Exercise Intervention on Serum Biomarkers of Angiogenesis in Postmenopausal Women: a randomized controlled trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
2013
Tang, JY, Henderson MT, Hernandez-Boussard T, Kubo J, Desai M, Sims ST, Aroda V, Thomas F, McTiernan A, Stefanick ML.  2013.  Lower Skin Cancer Risk in Women with Higher Body Mass Index: The Women's Health Initiative Observational Study.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Woolcott, CG, Courneya KS, Boyd NF, Yaffe MJ, McTiernan A, Brant R, Jones CA, Stanczyk FZ, Terry T, Cook LS et al..  2013.  Longitudinal Changes in IGF-I and IGFBP-3, and Mammographic Density among Postmenopausal Women.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(11):2116-20. Abstract
Mason, C, Alfano CM, Smith AW, Wang C-Y, Neuhouser ML, Duggan C, Bernstein L, Baumgartner KB, Baumgartner RN, Ballard-Barbash R et al..  2013.  Long-Term Physical Activity Trends in Breast Cancer Survivors.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Kwan, K, Chlebowski RT, McTiernan A, Rodabough RJ, Lamonte MJ, Martin LW, Bell C, Lane DS, Kaplan RC, Irwin ML.  2013.  Walking speed, physical activity, and breast cancer in postmenopausal women.. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). Abstract
Cash, SW, Duncan GE, Beresford SAA, McTiernan A, Patrick DL.  2013.  Increases in physical activity may affect quality of life differently in men and women: the PACE project.. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. Abstract