M.D., New York Medical College, 1989.
Ph.D., University of Washington, Epidemiology, 1982.
Prevention of new and recurrent breast and other cancer through physical activity, diet and chemoprevention.
Dr. McTiernan's research focuses on identifying ways to prevent new or recurrent cancer with a particular focus on weight control, physical activity, and chemoprevention. She is Principal Investigator of the Seattle TREC Center investigating mechanisms of energy balance and cancer prevention. She leads over twenty five scientists in transdisciplinary reasearch to elucidate the pathways linking components of energy balance to the cancer process. The five projects and four cores incorporate several different study designs, with contributions of scientists from medicine, cell biology, animal models, immunology, biostatistics, mathematics, exercise physiology, and behavioral science.
Dr. McTiernan is also Principal Investigator of a randomized controlled clinical trial of a one-year aerobic exercise intervention to compare the effects over one year of two lifestyle interventions in 503 postmenopausal women: (1) a moderate-intensity aerobic exercise intervention, and (2) a reduced-calorie diet plus moderate-intensity aerobic exercise intervention. She is Principal Investigator of the Seattle site of Health, Eating, Activity, and Lifestyle (HEAL) Study, which is assessing associations among anthropometrics, fat mass amount and distribution, endogenous sex and metabolic hormones, diet, and physical activity on prognostic factors in breast cancer patients. Dr. McTiernan is Principal Investigator of the Seattle site of the ExCel trial which is testing the effect of exemestane, an aromatase inhibitor, on breast cancer prevention, and she leads a randomized clinical trial testing aspirin effect on breast cancer biomarkers.
Previously she has conducted a randomized controlled clinical trial of a one-year aerobic exercise intervention vs. stretch control in 173 postmenopausal women. The primary aim of this study was to assess the effect of exercise on endogenous sex hormones that have been associated with increased risk for breast cancer. Ongoing ancillary studies test the effect of aerobic exercise on immune function and other biomarkers of breast cancer risk.
She is also been Principal Investigator of a randomized clinical trial to test the effect of a one-year aerobic exercise intervention vs. control on colorectal cell proliferation, apoptosis, and prostaglandin content, and on other biomarkers of colon cancer risk in 200 men and women with adenomatous colon polyps.
Dr. McTiernan was a co-Investigator in the Women's Health Initiative (WHI), and directed clinical outcomes efforts at the WHI Clinical Coordinating Center. She has conducted an analysis of physical activity and breast cancer incidence in the WHI Observational Study cohort of over 90,000 women and has collaborated on many additional analyses.
Dr. McTiernan has considerable experience with recruitment, retention, adherence, and endpoints in large-scale medication clinical trials (e.g. the Women's Health Initiative hormone therapy and calcium/vitamin D trials). She has expertise in Women's Health issues. She is co-investigator of the Seattle STAR trial, hence has experience with clinical trials using SERMS.
University of Washington Residency Training Internal Medicine 1992
American College of Epidemiology
American Society of Preventive Oncology
Society for Epidemiologic Research
The roles of support seeking and race/ethnicity in posttraumatic growth among breast cancer survivors.. Journal of psychosocial oncology. 31(4):393-412.. 2013.
Metabolic, hormonal and immunological associations with global DNA methylation among postmenopausal women.. Epigenetics : official journal of the DNA Methylation Society. 7(9). 2012.
Exercise Adherence, Cardiopulmonary Fitness and Anthropometric Changes Improve Exercise Self-Efficacy and Health-Related Quality of Life.. Journal of physical activity & health.. 2012.
Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study.. Journal of cancer survivorship : research and practice.. 2012.
Influence of Diet, Exercise, and Serum Vitamin D on Sarcopenia in Postmenopausal Women.. Medicine and science in sports and exercise.. 2012.
The Piper Fatigue Scale-12 (PFS-12): psychometric findings and item reduction in a cohort of breast cancer survivors.. Breast cancer research and treatment. 136(1):9-20.. 2012.
Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations.. Journal of exposure science & environmental epidemiology.. 2012.
Genetic Polymorphism CYP17 rs2486758 and Metabolic Risk Factors Predict Daily Salivary 17β-Estradiol Concentration in Healthy Premenopausal Norwegian Women. The EBBA-I Study.. The Journal of clinical endocrinology and metabolism. 97(5):E852-7.. 2012.
Vitamin D and Calcium Supplementation and One-Year Change in Mammographic Density in the Women's Health Initiative Calcium and Vitamin D Trial.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(3):462-73.. 2012.
Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review.. Journal of the National Cancer Institute. 104(11):815-40.. 2012.
Diabetes, Metformin, and Breast Cancer in Postmenopausal Women.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2012.
Sedentary Behavior, Health-Related Quality of Life and Fatigue among Breast Cancer Survivors.. Journal of physical activity & health.. 2012.
Associations of insulin-like growth factor and insulin-like growth factor binding protein-3 with mortality in women with breast cancer.. International journal of cancer. Journal international du cancer.. 2012.
The Role of Obesity in Cancer Survival and Recurrence.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2012.
Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(19):2314-26.. 2012.
Inflammatory marker changes in a yearlong randomized exercise intervention trial among postmenopausal women.. Cancer prevention research (Philadelphia, Pa.). 5(1):98-108.. 2012.
Breast tenderness after initiation of conjugated equine estrogens and mammographic density change.. Breast cancer research and treatment. 131(3):969-979.. 2012.
Breast tenderness and breast cancer risk in the estrogen plus progestin and estrogen-alone women's health initiative clinical trials.. Breast cancer research and treatment. 132(10):275-285.. 2012.
Injuries in sedentary individuals enrolled in a 12-month, randomized, controlled, exercise trial.. Journal of physical activity & health. 9(2):198-207.. 2012.
History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women.. Metabolism: clinical and experimental.. 2012.
Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women.. Obesity (Silver Spring, Md.). 20(8):1628-38.. 2012.
Fatigue, Inflammation, and ω-3 and ω-6 Fatty Acid Intake Among Breast Cancer Survivors.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(7):1280-7.. 2012.