M.D., New York Medical College, 1989.
Ph.D., University of Washington, Epidemiology, 1982.
Prevention of new and recurrent breast and other cancer through physical activity, diet and chemoprevention.
Dr. McTiernan's research focuses on identifying ways to prevent new or recurrent cancer with a particular focus on weight control, physical activity, and chemoprevention. She is Principal Investigator of the Seattle TREC Center investigating mechanisms of energy balance and cancer prevention. She leads over twenty five scientists in transdisciplinary reasearch to elucidate the pathways linking components of energy balance to the cancer process. The five projects and four cores incorporate several different study designs, with contributions of scientists from medicine, cell biology, animal models, immunology, biostatistics, mathematics, exercise physiology, and behavioral science.
Dr. McTiernan is also Principal Investigator of a randomized controlled clinical trial of a one-year aerobic exercise intervention to compare the effects over one year of two lifestyle interventions in 503 postmenopausal women: (1) a moderate-intensity aerobic exercise intervention, and (2) a reduced-calorie diet plus moderate-intensity aerobic exercise intervention. She is Principal Investigator of the Seattle site of Health, Eating, Activity, and Lifestyle (HEAL) Study, which is assessing associations among anthropometrics, fat mass amount and distribution, endogenous sex and metabolic hormones, diet, and physical activity on prognostic factors in breast cancer patients. Dr. McTiernan is Principal Investigator of the Seattle site of the ExCel trial which is testing the effect of exemestane, an aromatase inhibitor, on breast cancer prevention, and she leads a randomized clinical trial testing aspirin effect on breast cancer biomarkers.
Previously she has conducted a randomized controlled clinical trial of a one-year aerobic exercise intervention vs. stretch control in 173 postmenopausal women. The primary aim of this study was to assess the effect of exercise on endogenous sex hormones that have been associated with increased risk for breast cancer. Ongoing ancillary studies test the effect of aerobic exercise on immune function and other biomarkers of breast cancer risk.
She is also been Principal Investigator of a randomized clinical trial to test the effect of a one-year aerobic exercise intervention vs. control on colorectal cell proliferation, apoptosis, and prostaglandin content, and on other biomarkers of colon cancer risk in 200 men and women with adenomatous colon polyps.
Dr. McTiernan was a co-Investigator in the Women's Health Initiative (WHI), and directed clinical outcomes efforts at the WHI Clinical Coordinating Center. She has conducted an analysis of physical activity and breast cancer incidence in the WHI Observational Study cohort of over 90,000 women and has collaborated on many additional analyses.
Dr. McTiernan has considerable experience with recruitment, retention, adherence, and endpoints in large-scale medication clinical trials (e.g. the Women's Health Initiative hormone therapy and calcium/vitamin D trials). She has expertise in Women's Health issues. She is co-investigator of the Seattle STAR trial, hence has experience with clinical trials using SERMS.
University of Washington Residency Training Internal Medicine 1992
American College of Epidemiology
American Society of Preventive Oncology
Society for Epidemiologic Research
Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(19):2314-26.. 2012.
Inflammatory marker changes in a yearlong randomized exercise intervention trial among postmenopausal women.. Cancer prevention research (Philadelphia, Pa.). 5(1):98-108.. 2012.
Breast tenderness after initiation of conjugated equine estrogens and mammographic density change.. Breast cancer research and treatment. 131(3):969-979.. 2012.
Breast tenderness and breast cancer risk in the estrogen plus progestin and estrogen-alone women's health initiative clinical trials.. Breast cancer research and treatment. 132(10):275-285.. 2012.
Injuries in sedentary individuals enrolled in a 12-month, randomized, controlled, exercise trial.. Journal of physical activity & health. 9(2):198-207.. 2012.
History of weight cycling does not impede future weight loss or metabolic improvements in postmenopausal women.. Metabolism: clinical and experimental.. 2012.
Effect of diet and exercise, alone or combined, on weight and body composition in overweight-to-obese postmenopausal women.. Obesity (Silver Spring, Md.). 20(8):1628-38.. 2012.
Fatigue, Inflammation, and ω-3 and ω-6 Fatty Acid Intake Among Breast Cancer Survivors.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(7):1280-7.. 2012.
Randomized controlled pilot trial of yoga in overweight and obese breast cancer survivors: effects on quality of life and anthropometric measures.. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 20(2):267-277.. 2012.
Predictors of Adherence to Supervised and Unsupervised Exercise in the Alberta Physical Activity and Breast Cancer Prevention Trial.. Journal of physical activity & health.. 2011.
Dietary fiber is associated with circulating concentrations of C-reactive protein in breast cancer survivors: the HEAL study.. Breast cancer research and treatment. 129(2):485-94.. 2011.
Dietary weight loss and exercise effects on insulin resistance in postmenopausal women.. American journal of preventive medicine. 41(4):366-75.. 2011.
Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL Study report.. BMC complementary and alternative medicine. 11(1):109.. 2011.
Shorter telomeres associate with a reduced risk of melanoma development.. Cancer research. 71(21):6758-63.. 2011.
Sleep duration change across breast cancer survivorship: associations with symptoms and health-related quality of life.. Breast cancer research and treatment. 130(1):243-54.. 2011.
Weight cycling and cancer: weighing the evidence of intermittent caloric restriction and cancer risk.. Cancer prevention research (Philadelphia, Pa.). 4(11):1736-42.. 2011.
Effects of 12-month exercise on health-related quality of life: a randomized controlled trial.. Preventive medicine. 52(5):344-51.. 2011.
Dietary fiber, carbohydrates, glycemic index, and glycemic load in relation to breast cancer prognosis in the HEAL cohort.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(5):890-9.. 2011.
Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancer.. Journal of the National Cancer Institute. 103(6):470-7.. 2011.
Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial.. International journal of obesity (2005). 35(3):427-35.. 2011.
Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(3):454-63.. 2011.
Genetic variants in the MRPS30 region and postmenopausal breast cancer risk.. Genome medicine. 3(6):42.. 2011.
Exemestane for breast-cancer prevention in postmenopausal women.. The New England journal of medicine. 364(25):2381-91.. 2011.