Polly A. Newcomb

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Cancer Prevention
Public Health Sciences
Member and Program Head
Comprehensive Cancer Center
University of Wisconsin Medical School
Senior Scientist
University of Washington
School of Public Health and Community Medicine
Epidemiology
Professor (Research)
Professional Headshot of Polly A. Newcomb

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N
P.O. Box 19024
M4-B402
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 667-3476
Fax: (206) 667-7850
pnewcomb@fhcrc.org
http://www.fhcrc.org/content/public/en/labs/phs/projects/cancer-prevention.html

Degrees

Postdoctoral Fellow, University of Wisconsin-Madison, Cancer Biology, 1986.
Ph.D., University of Washington, Epidemiology.
M.P.H., University of Washington, Epidemiology.

Research Interests

As a cancer epidemiologist, the focus of my research is on the identification of modifiable risk factors for common cancers, particularly breast and colon cancer. Since many of these risk factors appear to have only modest magnitudes of effect, more precisely identifying susceptible individuals defined by genes, epigenetic changes, or personal characteristics such as body size may help direct investigations in the population, laboratory and clinic. These risk factors are also plausibly related to survival after diagnosis and several studies are examining characteristics associated with longevity.

Other interests include: the interaction of genes and the etiology of cancer; and approaches to the secondary prevention of cancer using new markers for early detection, as well as established technologies.

http://www.fhcrc.org

Memberships

American Association for Cancer Research
American Society of Preventive Oncology
Society for Epidemiologic Research
The International Society for Research in Human Milk and Lactation

Honors and Awards

2009, UICC Yamagiwa-Yoshida Memoria International Cancer Study Fellowship Award, UICC
2009, Mid-Career Women Faculty Professional Development Seminar, AAMC
2009, Peggy Means Leadership Development Award, FHCRC
2010, University of Washington School of Public Health Faculty Mentor Award, University of Washington, Seattle

Previous Positions

2002-2003, Acting Program Head, Fred Hutchinson Cancer Research Center, Cancer Prevention, Public Health Sciences
1996-1998, Associate Professor (Affiliate), University of Washington, Public Health, Epidemiology
1995-1997, Associate Member, Fred Hutchinson Cancer Research Center
1995-1999, Associate Professor, University of Wisconsin-Madison, School of Medicine and Public Health, Medicine
1994-1995, Associate Professor, University of Wisconsin-Madison, School of Medicine and Public Health, Human Oncology
1988-1994, Assistant Professor, University of Wisconsin-Madison, School of Medicine and Public Health, Human Oncology
1987-1988, Assistant Scientist, University of Wisconsin-Madison, School of Medicine and Public Health, Human Oncology
1987-1988, Assistant Scientist, University of Wisconsin-Madison, School of Medicine and Public Health, Preventive Medicine

Funding

  • National Institutes of Health (NIH): Association Between HIV and Survival after Cancer Diagnosis, $100,000, 2010 to 2012.
  • National Institutes of Health (NIH): GWAS Identified Colorectal Cancer SNPs and Colorectal Polyp Risk, $100,000, 2010 to 2012.
  • National Institutes of Health (NIH): Human Papillomavirus Association with Subsets of Colorectal Cancer, $100,000, 2009 to 2011.
  • National Institutes of Health (NIH): NSAIDS, Genetic Variability, and Colon Cancer Survival, $100,000, 2008 to 2010.
  • NIH: Inflammation and Innate Immunity Genes and Colorectal Cancer Risk, $286,681, 2008 to 2012.
  • National Institutes of Health (NIH): Hormones and Colon Cancer Subtypes, Risk, and Survival, $750,000, 2006 to 2011.
  • Avon Foundation, Breast Cancer Prevention Research Initiative: Age at First Birth and Breast Cancer Histology, $265,000, 2006 to 2010.
  • Susan B. Komen Breast Cancer Foundation: Influence of Diet and Lifestyle on Breast Cancer Outcomes, $190,566, 2004 to 2008.
  • National Institutes of Health (NIH): Leptin, IGFs and Colorectal Adenoma Cancer Risk, $100,000, 2004 to 2008.
  • National Institutes of Health (NIH): Colon Cancer Pathways: Hyperplastic Polyps & Adenomas, $2,381,022, 2003 to 2010.
  • National Institutes of Health (NIH): IGF Polymorphisms, Lifestyle Factors, and Colon Cancer Risk, $100,000, 2002 to 2005.
  • National Institutes of Health (NIH): Breast Cancer In Situ Recurrence and Quality of Life, $1,250,000, 2002 to 2007.
  • National Institutes of Health (NIH): Medications, Genetic Variability, and Breast Cancer, $2,058,824, 2002 to 2011.
  • National Institutes of Health (NIH): Seattle Familial Colorectal Cancer Registry, $6,328,766, 2002 to 2012.
  • National Institutes of Health (NIH): VDR Polymorphisms, Sunlight Exposure and Colon Cancer, $82,704, 2000 to 2004.
  • National Institutes of Health (NIH): Physical Activity, Lifestyle and Ovarian Cancer Risk (supplement), $268,034, 1998 to 2001.
  • National Institutes of Health (NIH): Hormone Replacement Therapy and Large Bowel Cancer, $1,489,303, 1998 to 2004.
  • National Institutes of Health (NIH): Seattle Familial Colorectal Cancer Registry, $2,130,814, 1997 to 2002.
  • National Institutes of Health (NIH): Polymorphisms in NAT2 and Breast Cancer Risk (Buccal), $49,989, 1996 to 1999.
  • National Institutes of Health (NIH): Physical Activity, Lifestyle and Breast Cancer Risk, $1,245,318, 1996 to 2001.
  • National Institutes of Health (NIH): Risk Factors and Biomarkers for in situ Breast Cancer, $1,310,063, 1996 to 2001.
  • National Institutes of Health (NIH): Efficacy of Mammography in Younger Women - University of Wisconsin Cancer Center (Comprehensive) - Project, $15,000, 1995 to 1996.
  • National Institutes of Health (NIH): Molecular Basis of Environmental Risk Factors in Breast Cancer - University of Wisconsin Cancer Center (Comprehensive) - Project, $23,000, 1994 to 1996.
  • National Institutes of Health (NIH): Hormones, Alcohol and Breast Cancer Risk, $964,000, 1992 to 1996.
  • American Cancer Society (ACS): Postmenopausal Progestogen Use and Risk of Endometrial Cancer, $168,000, 1991 to 1995.
  • Public Health Service - Centers for Disease Control: BRFS Food Frequency Validity Study, $13,500, 1990 to 1991.
  • Alcoholic Beverage Medical Research Foundation: Alcohol Consumption, and Colorectal Cancer Risk, $53,400, 1990 to 1993.
  • American Cancer Society (ACS): Alcohol Consumption and Cancer of the Large Bowl in Women, $60,000, 1989 to 1992.
  • National Institutes of Health (NIH): Alcohol Consumption, Lactation, and Breast Cancer Risk, $940,000, 1988 to 1992.
  • National Institutes of Health (NIH): Efficacy of Fecal Occult Blood Screening, $33,536, 1987 to 1988.
  • Public Health Service - Centers for Disease Control: Evaluation of Diabetic Eye Care Screening Program, $56,000, 1986 to 1988.
  • American Cancer Society (ACS): Validity of Reported Breast Self-Examination Practice, $2,500, 1986 to 1988.

 

Recent Publications

2014
Hart McLaughlin, V, Trentham-Dietz A, Hampton JM, Newcomb PA, Sprague BL.  2014.  Lifestyle factors and the risk of a second breast cancer after ductal carcinoma in situ.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Lowery, JT, Horick N, Kinney AY, Finkelstein DM, Garrett K, Haile RW, Lindor NM, Newcomb PA, Sandler RS, Burke CA et al..  2014.  A randomized trial to increase colonoscopy screening in members of high risk families in the Colorectal Cancer Family Registry and Cancer Genetics Network.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Ahsan, H, Halpern J, Kibriya MG, Pierce BL, Tong L, Gamazon ER, McGuire V, Felberg A, Shi J, Jasmine F et al..  2014.  A Genome-wide Association Study of Early-onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
2013
Wang, H, Taverna D, Stram DO, Fortini BK, Cheng I, Wilkens LR, Burnett T, Makar KW, Lindor NM, Hopper JL et al..  2013.  Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 22(11):2094-101. Abstract
Derycke, MS, Gunawardena SR, Middha S, Asmann YA, Schaid DJ, McDonnell SK, Riska SM, Eckloff BW, Cunningham JM, Fridley BL et al..  2013.  Identification of Novel Variants in Colorectal Cancer Families by High-Throughput Exome Sequencing.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Abstract
Passarelli, MN, Newcomb PA, LaCroix AZ, Lane DS, Ho GYF, Chlebowski RT.  2013.  Oral bisphosphonate use and colorectal cancer incidence in the Women's Health Initiative.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Abstract