Ross L. Prentice
Ph.D., University of Toronto, Statistics, 1970.
M.Sc., University of Toronto, Statistics, 1968.
B.Sc., University of Waterloo, Mathematics, 1967.
My statistical methods research, in conjunction with colleagues and students aims to improve the design and analysis of disease prevention trials, and observational studies. Recent efforts have brought attention to the profound role that measurement error in assessing individual dietary intakes may play in reducing the reliability of observational studies of food and nutrient consumption and the risk of cancer and other chronic diseases. As a result an innovative research agenda has been advocated thatincludes a major emphasis on international comparisons of dietary habits and cancer incidence rates, the addition of objective biomarkers of nutrient intake to the conduct of cohort and case-control studies, and a major emphasis on dietary intervention development for subsequent testing in controlled intervention trials. Another emphasis has been the development of flexible methods for the analysis of multivariate failure time data. These methods are motivated by the challenges of assessing benefits versus risks in the context of disease prevention trials having multiple clinical outcomes that may be affected by a preventive intervention, and by emerging issues in the identification of cancer related genes and gene-environment interactions.
My applied research, in conjunction with a large group of colleagues and staff members, include coordination of the national Women's Health Initiative. This massive 15 year program randomized over 68,135 postmenopausal women into a clinical trial to evaluate therole of a low-fat eating pattern for the prevention of breast cancer, colorectal cancer and coronary heart disease; to evaluate the role of hormone replacement therapy for the prevention of coronary heart disease and fractures, with breast cancer as a potential adverse outcome; and to evaluate the role of calcium and vitamin D supplementation for the prevention of fractures and colorectal cancer. An additional 93,720 women have been enrolled in an observational study to identify risk factors for this same range of diseases. We operate the clinical coordinating center for this NIH-sponsored program, with clinical, nutritional, epidemiologic, statistical and data management coordination responsibilities. We expect to report the principal findings from the Women's Health Initiative Clinical Trial in 2005-2007.
American Association of Preventive Oncology
American Statistical Association
Institute of Medicine
International Biometric Society
Honors and Awards
2010, Visiting Scholor, National Cancer Intitute DCEG
2008, Member, Washington State Academy of Sciences, Washington State
2008, COPSS R.A. Fisher Lectureship (ASA, Biometric Society IMS and SSC), National Cancer Institute
2005, Award for Research Excellence in Epidemiology and Prevention, American Cancer Society
2005, Marvin Zelen Leadership Award for Outstanding Achievement in Statistical Science, Harvard University
2003, Mantel Award for Lifetime Contributions to Statistics in Epidemiology, American Statitical Association
2002, Alumni Achievement Medal, Faculty of Mathematics, University of Waterloo
1990, Elected Member, Institute of Medicine, National Academy of Sciences
1986, COPSS President's Award, ASA, Biometric Society, IMS and SSC
1982, Fellow, American Statistical Association
1980, Mortimer Spiegelman Award, APHA
1978, Purdue Frederick Award, ACOG
1980-1981, Biostatistician, Radiation Effects Research Foundation
1974-1977, Associate Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1971-1972, Visiting Assistant Professor, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Statistics
1970-1974, Assistant Professor, University of Waterloo, Statistics
Regression Calibration in Nutritional Epidemiology: Example of Fat Density and Total Energy in Relationship to Postmenopausal Breast Cancer.. American journal of epidemiology.. 2013.
Calibration of self-reported dietary measures using biomarkers: an approach to enhancing nutritional epidemiology reliability.. Current atherosclerosis reports. 15(9):353.. 2013.
Menopausal hormone therapy and health outcomes during the intervention and extended poststopping phases of the Women's Health Initiative randomized trials.. JAMA : the journal of the American Medical Association. 310(13):1353-68.. 2013.
An Exploratory Study of Respiratory Quotient Calibration and Association with Postmenopausal Breast Cancer.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2013.
The Role of Epidemiology in the Era of Molecular Epidemiology and Genomics: Summary of the 2013 AJE-sponsored Society of Epidemiologic Research Symposium.. American journal of epidemiology. 178(9):1350-4.. 2013.
Physical Activity Assessment: Biomarkers and Self-Report of Activity-Related Energy Expenditure in the WHI.. American journal of epidemiology. 177(6):576-85.. 2013.
Proteomic profiling of the autoimmune response to breast cancer antigens uncovers a suppressive effect of hormone therapy.. Proteomics. Clinical applications. 7(5-6):327-336.. 2013.
Estrogen Plus Progestin and Breast Cancer Incidence and Mortality in the Women's Health Initiative Observational Study.. Journal of the National Cancer Institute. 105(8):526-35.. 2013.
Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study.. Obesity (Silver Spring, Md.). 21(4):835-46.. 2013.
Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.. Breast cancer research and treatment. 135(2):611-8.. 2012.
Estrogen plus progestin and colorectal cancer incidence and mortality.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(32):3983-90.. 2012.
Hazard Ratio Estimation for Biomarker-Calibrated Dietary Exposures.. Biometrics. 68(2):397-407.. 2012.
Simultaneously testing for marginal genetic association and gene-environment interaction.. American journal of epidemiology. 176(2):164-73.. 2012.
Exploring the interaction between SNP genotype and postmenopausal hormone therapy effects on stroke risk.. Genome medicine. 4(7):57.. 2012.
Meta-analysis of new genome-wide association studies of colorectal cancer risk.. Human genetics. 131(2):217-234.. 2012.
Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction.. Biometrika. 99(4):929-944.. 2012.
Increased plasma levels of the APC-interacting protein MAPRE1, LRG1 and IGFBP2 preceding a diagnosis of colorectal cancer in women.. Cancer prevention research (Philadelphia, Pa.). 5(4):655-664.. 2012.
Fine mapping of 14q24.1 breast cancer susceptibility locus.. Human genetics.. 2011.