Martin Prlic

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease
Immunology & Vaccine Development
Assistant Member
Professional Headshot of Martin  Prlic

Mailing Address

1100 Fairview Ave N
E5-110
PO Box 19024
Seattle, Washington 98109-1024
United States

Contact

Degrees

Ph.D., University of Minnesota, Microbiology, Immunology and Cancer Biology (MICaB) Program, 2004.
M.Sc., University of Salzburg, Genetics, 1999.

Research Interests

My laboratory mainly focuses on two populations of the adaptive immune system: CD8 T cells and NK cells. We study these cells in a variety of different in vivo (mouse) and in vitro model systems to gain mechanistic insight and learn how to manipulate these cells for therapeutic purposes. Here is a brief overview of the main goals of the laboratory:

Many established vaccination programs are mainly dependent on an efficient antibody response, but current challenges such as malaria, HIV and tuberculosis appear to require a different approach. My laboratory is interested in understanding the mechanisms that drive a nave T cell to differentiate into an effector T cell and then a memory T cell. CD8 T cells are a key player in protecting us against intracellular pathogens (such as viruses and certain intracellular bacteria). A thorough understanding of how CD8 T cell memory is generated and maintained will provide us with more insight and better vaccination strategies.

For various malignancies, bone marrow transplantation (BMT) has become an important therapeutic approach. During BMT, the patient's population of leukocytes and stem cells is ablated, followed by transfer of autologous (self derived) or allogeneic (donor derived) hematopoietic stem cells. Some inherent difficulties with this therapeutic approach range from relapse of the tumor, to onset of graft versus host disease (GvHD). Another complication of BMT is increased susceptibility to infections due to the lack of a fully functional immune system. My lab is interested is studying the role and therapeutic potential of NK cells in mediating protection against these opportunistic infections.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
German: (Fluent, Fluent, Fluent)

Memberships

American Association of Immunologists

Honors and Awards

2009, AAI-Invitrogen Trainee Achievement Award, American Association of Immunologists
2009, K99/R00 Pathway to Independence Award, National Institutes of Health (NIH), NIAID
2008, Theodor Koerner Award, Austria
2008, Special Fellow Award, Leukemia & Lymphoma Society
2008, "Talenteforderungspramie fur Wissenschaft", Austria
2005, Fellow Award, Leukemia & Lymphoma Society
2004, Veneziale-Steer Award, Minnesota Medical Foundation
2003, Travel Award, Microbiology, Cancer Biology & Immunology Graduate Program, University of Minnesota
2003, Golden Pipetman Award, Microbiology, Cancer Biology & Immunology Graduate Program, University of Minnesota
2002-2003, Student Representative, Microbiology, Cancer Biology & Immunology Graduate Program, University of Minnesota
1999, Outstanding Academic Performance stipend, University of Salzburg

Previous Positions

2004-2010, Post-doctoral fellow, University of Washington, Immunology, Howard Hughes Medical Institute

Funding

  • National Institutes of Health (NIH): K99/R00 CD8 T Cell Contraction and Memory Formation, 2009 to 2013.
  • The Leukemia and Lymphoma Society: Special Fellow Award, 2008 to 2009.
  • The Leukemia and Lymphoma Society: Fellow Award, 2005 to 2008.

 

Recent Publications

2014
2013
2012
2011