Peter S. Rabinovitch

Appointments and Affiliations

University of Washington
School of Medicine
Pathology
Professor, Appointed: 1992
Fred Hutchinson Cancer Research Center
Public Health Sciences
Joint Member, Appointed: 1998
Professional Headshot of Peter S. Rabinovitch

Mailing Address

Department of Pathology
RM K081 HSB
Box 357705
Seattle, Washington 98195-7705
United States

Contact

Phone: (206) 685-3761
Fax: (206) 616-8571
petersr@u.washington.edu
http://www.pathology.washington.edu/research/labs/rabinovitch/

Degrees

Ph.D., University of Washington, Genetics, 1980.
M.D., University of Washington, Medicine, 1979.

Research Interests

The focus of the laboratory is upon studies of DNA damage and genomic instability in aging and in neoplastic progression. In aging, we are interested in the connection between DNA damage and free radical injury and lifespan and disease. Transgenic mice that overexpress antioxidant enzymes have enhanced longevity and are being examined to provide insights in this model system. In particular, mice hat overexpress catalase targeted to mitochondria have extended longevity, and healthspan - the latter includes resistance to cardiac aging and experimental heart disease, reduced sarcopenia, and resistance to non-hematological malignancies. Studies of neoplastic progression focus on human gastrointestinal cancers and precancerous diseases such as Ulcerative Colitis. A better understanding of neoplastic progression in these diseases may yield biomarkers of increased clinical risk for progression to cancer. Genomic instability has proven to be one such a marker. In both aging and neoplasia, we are interested in the role of telomere shortening in promoting genomic instability. Additional molecular genetic and cytometric indicators of genomic instability and DNA repair are being studied.

Additional Experience

Director, University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging

Director, University of Washington Genetic Approaches to Aging Training Grant

Director, Anatomic Pathology Flow Cytometry Laboratory, University of Washington Medical Center

Memberships

International Society for Analytical Cytology

Patents

DNA Libraries (Methods for making and using single-chromosome amplification libraries, Patent Number: 5814444, , , United States of America.

Recent Publications

2014
2013
2012
2011
2010
2009
2008