Timothy W. Randolph

Appointments and Affiliations
 
 
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics and Biomathematics
Appointed: 2006
 Professional Headshot of Timothy W. Randolph

Mailing Address

1100 Fairview Ave. N
M2-B500
Seattle, Washington 98109
United States

Degrees

Ph.D., University of Oregon, Mathematics, 1990.
M.S., University of Oregon, Mathematics, 1984.
B.S., University of Puget Sound, Mathematics, 1982.

Research Interests

Current research focuses on processing, classification and analysis of high-dimensional and/or functional data output from protein mass spectrometry, genetic assays and a variety of spectroscopies and imaging modalities. Other interests include methods for the analysis of networks used to describe gene and/or protein interactions. Additional experience includes lead statistician on biomarker validation studies within the NIH Early Detection Research Network.

Additional Experience

A career in mathematics began with a focus on functional analysis, spectral theory of operators and Fredholm theory. Teaching experience as an associate professor includes over 20 different course titles in undergraduate and graduate mathematics and advising for undergraduate and graduate students.

My original research evolved into the study of mathematical control theory, including the study of dynamics and stability of infinite-dimensional linear control systems (those described by system of partial differential and delay equations). An NIH career-transition award provided the opportunity to shift from a research emphasis in pure mathematics to the development of methods for analysis, computation and models of biological/biomedical data.

Memberships

Society of Industrial and Applied Mathematics

Honors and Awards

1998, Dynamics and Control of Nonautonomous Systems, The Missouri Research Board
1994, Spectral Mapping Properties and Stabilization of Control Systems, The Missouri Research Board
1994-1995, Eigenproperties of Damped Dynamic Systems, The Missouri Research Board

Previous Positions

2002-2006, Senior Fellow, University of Washington, Biostatistics
1997, Visiting Associate Professor, University of Missouri-Columbia, Mathematics
1997-2003, Tenured Associate Professor, University of Missouri-Rolla, (Missouri University of Science and Technology)
1991-1996, Assistant Professor, University of Missouri-Rolla, Mathematics & Statistics
1984-1985, Instructor, University of the Pacific, Mathematics

Funding

  • R21 RR025787 (R. Gardner and T. Randolph, PI): Discovery of substrates of ubiquitin-protein ligases---the development of integrated experimental and computational methods, 2009 to 2011.
  • R01-GM082802, NIGMS, (co-investigator; P. Wang, PI): Statistical Methods for Integrative Analysis of Genomics and Proteomics Data, 2008 to 2013.
  • R01-CA126205, NCI, (T. Randolph, PI): Quantitative Methods for Spectral and Image Data in Proteomics Research, 2007 to 2012.
  • P01-CA053996, NCI (R. Prentice, PI): Statistical Methodologies, 2006 to 2011.
  • K25-GM067211 NIGMS, (T. Randolph, PI): Biomarkers in High-Dimensional Data From Genomics and Proteomics Technologies, 2002 to 2007.

 

Recent Publications

2012
Yan, D, Wang P, Knudsen BS, Linden M, Randolph TW.  2012.  Statistical Methods for Tissue Array Images - Algorithmic Scoring and Co-training.. The annals of applied statistics. 6(3):1280-1305. Abstract
Holte, SE, Randolph TW, Ding J, Tien J, McClelland RS, Baeten JM, Overbaugh J.  2012.  Efficient use of longitudinal CD4 counts and viral load measures in survival analysis.. Statistics in medicine. Abstract
Randolph, TW, Harezlak J, Feng Z.  2012.  Structured penalties for functional linear models-partially empirical eigenvectors for regression.. Electronic journal of statistics. 6:323-353. Abstract
Teckchandani, A, Mulkearns EE, Randolph TW, Toida N, Cooper JA.  2012.  The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis.. Molecular biology of the cell. 23(15):2905-2916. Abstract
Elashoff, D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A et al..  2012.  Prevalidation of Salivary Biomarkers for Oral Cancer Detection.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(4):664-672. Abstract
2011
Brauer, HA, Libby TE, Mitchell BL, Li L, Chen C, Randolph TW, Yasui YY, Lampe JW, Lampe PD.  2011.  Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner.. Nutrition journal. 10:11. Abstract
2010
Yu, X, Randolph TW, Tang H, Hsu L.  2010.  Detecting genomic aberrations using products in a multiscale analysis.. Biometrics. 66(3):684-93. Abstract
2008
Qiu, J, Choi G, Li L, Wang H, Pitteri SJ, Pereira-Faca SR, Krasnoselsky AL, Randolph TW, Omenn GS, Edelstein C et al..  2008.  Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26(31):5060-6. Abstract
McLerran, D, Grizzle WE, Feng Z, Bigbee WL, Banez LL, Cazares LH, Chan DW, Diaz J, Izbicka E, Kagan J et al..  2008.  Analytical validation of serum proteomic profiling for diagnosis of prostate cancer: sources of sample bias.. Clinical chemistry. 54(1):44-52. Abstract
McLerran, D, Grizzle WE, Feng Z, Thompson IM, Bigbee WL, Cazares LH, Chan DW, Dahlgren J, Diaz J, Kagan J et al..  2008.  SELDI-TOF MS whole serum proteomic profiling with IMAC surface does not reliably detect prostate cancer.. Clinical chemistry. 54(1):53-60. Abstract
McLerran, DF, Feng Z, Semmes JO, Cazares L, Randolph TW.  2008.  Signal detection in high-resolution mass spectrometry data.. Journal of proteome research. 7(1):276-85. Abstract