Researcher Profiles
Related Websites
Barbra A. Richardson
Degrees
Ph.D., University of California, Los Angeles, Biostatistics, 1993.
M.S., University of California, Los Angeles, Biostatistics, 1989.
B.A., Pomona College, Mathematics, 1987.
Research Interests
My main statistical methods research interests are concentrated on developing methods for analysis of infectious disease data and methods for analysis of data with missing values. Recently I worked on developing methodology to estimate breastmilk infectivity among HIV-1 infected mothers, and continue to collaborate on the development of survival analysis methods when the outcome variable is measured with uncertainty.
The majority of my collaborative work has been in HIV-1 prevention studies. I have been involved in studies investigating transmission of HIV-1 through breastfeeding, including serving as lead statistician of a randomized clinical trial to determine the frequency and timing of breastmilk transmission. Additional collaboration on this study has led to analyses determining correlates of genital and breastmilk shedding of HIV-1 DNA, and investigating the effects of breastfeeding on disease progression of HIV-1 infected mothers. I was also involved in a large cohort study with the primary aim of determining whether cytotoxic T lymphocytes in HIV-uninfected exposed infants have a role in protecting against breastmilk transmission of HIV-1. I also was a member of an international working group researching epidemiological, biostatistical, and clinical issues in mother-to-child transmission of HIV-1 (The Ghent Group) As an investigator at the Statistical Center for HIV/AIDS Research and Prevention (SCHARP) at The Fred Hutchinson Cancer Research Center, I am involved as lead statistician on a variety of studies of microbicides as preventive agents for sexual transmission of HIV-1 - including HPTN 035. In this role I collaborate on protocol teams and provide expertise in study design and other aspects of study development, conduct, and analysis. I served as the principal investigator (PI) for the statistical coordinating center for the NICHD sponsored HC-HIV study (based at SCHARP). This was a prospective cohort study of over 6,000 women in Thailand, Uganda, and Zimbabwe family planning clinics. The primary aim of the study was to determine if the use of hormonal contraception by HIV-1 uninfected women increases their risk of acquiring HIV-1. I currently serve as the co-PI for the statistical coordinating center for the NIH funded Microbicides Trials Network (MTN). Additional Experience
Lead Statistician for >2 dozen clinical trials and observational studies, 1993-present
Statistical Reviewer, Journal of Infectious Diseases, 1994-2002 Member, HIV Prevention Trials Network STD Working Group, 1999-2000 Member HIV Prevention Trials Network Microbicide Working Group, 2000-2006 Member, Bordeaux International Working Group on Methodology for Trials and Mother-to-Child Transmission of HIV-1, 2000-present Reviewer, NICHD Review Committee for RFA for a Global Network Research unit for Women's and Children's Health, 2000 Reviewer, XIV International AIDS Conference, 2002 Reviewer, Canadian Institutes of Health Research, 2002 Steering Committee Member, 6th National Symposium of the National Institutes of Health Centers for AIDS Research, 2002 Member, HIV Vaccine Trials Network Safety Monitoring Board, 2003-present Reviewer, Nestle Foundation, 2003 Advisor, Workshop to discuss data analysis of studies on infant feeding and HIV-transmission and HIV-free survival, World Health Organization, Geneva, Switzerland, November 2003 Reviewer, XV International AIDS Conference, 2004 Chair, Data Safety and Monitoring Board for "Methods for Improving Reproductive Health in Africa" (MIRA) trial, Bill and Melinda Gates Foundation, 2004-2007 Reviewer, NIAID Review Panel for RFP for the DAIDS Virology Quality Assurance Program, March 2005 Reviewer, 3rd IAS Conference on HIV Pathogenesis and Treatment, 2005 Expert Witness, undisclosed case, Round Table Group, 2005-present Member, Data Safety and Monitoring Board for Theratechnologies Inc. Protocol TH9507/III/LIPO/010, 2005-2007 Member, Data Safety and Monitoring Board for Theratechnologies Inc. Protocol TH9507/III/LIPO/011, 2006-2008 Chair, Data Safety and Monitoring Board for "Contraceptive Effectiveness and Safety Study of the SILCS Diaphragm: the Pivotal Study", CONRAD, 2007-present Regional Committee Member, WNAR of IBS, 2005-2007 Scientific Reviewer, Bill and Melinda Gates Foundation, 2008 Chair, Data Safety and Monitoring Board for "Sperm suppression and contraceptive protection provided by Norethisterone Enantate (Net-En) combined with Testosterone Undecanoate (TU) in healthy men", CONRAD and WHO, 2008-present Member, Data Safety and Monitoring Board for "An open-label randomized study of pneumococcal conjugate vaccination in HIV in comparison to polysaccharide vaccine boosting in previously vaccinated patients", Tri-Service AIDS Research Clinical Consortium, NIH, U.S. Military HIV Research Program, 2008. Journal Review: Editorial Board: AIDS, 2006-present Referee: AIDS American Journal of Epidemiology Biometrics Expert Review of Anti-infective Therapy Journal of Acquired Immune Deficiency Syndromes Journal of the American Medical Association Journal of Infectious Diseases Journal of Virological Methods Journal of Virology Nature Nature Medicine Sexually Transmitted Diseases Statistics in Medicine The American Journal of the Medical Sciences The Lancet The Lancet Infectious Diseases Languages(Reading, Writing, Speaking)
Spanish: (Basic, Basic, Basic)
Honors and Awards
2006-2008, Who's Who in Science and Engineering, Marquis
2001, Nominee, Distinguished Graduate Mentor Award, University of Washington
2000, Young Investigator Award, International AIDS Society
1994-1996, Awardee, NIH Post-Doctoral Fellowship in AIDS/STD
1992, Ruth F. Richards Outstanding Student Award, UCLA School of Public Health Alumni Association
1992, Finalist, Society for Clinical Trials Student Scholarship
1989, Elected Member, Iota Chapter of the Delta Omega Society (honorary public health society), UCLA
1987, William Honnold Fellowship for Graduate Study, Pomona College
1987-1992, Traineeship, UCLA, Biostatistics
Previous Positions
2004-2009, Joint Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Biostatistics
2003-2009, Research Associate Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1996-2003, Research Assistant Professor, University of Washington, School of Public Health and Community Medicine, Biostatistics
1993-1996, NIH Post Doctoral Fellow, University of Washington, Center for AIDS Research, Medicine, Infectious Diseases
1990-1992, Research Assistant, University of California, Los Angeles, Southern California Injury Prevention Research Center
1989-1990, Statistical Consultant, Price Waterhouse, Dispute Analysis and Corporate Recovery Department, Century
1988-1989, Teaching Assistant, University of California, Los Angeles, School of Public Health, Biostatistics
1987-1992, Research Assistant, University of California, Los Angeles, School of Public Health, Biostatistics
1985-1987, Actuarial Student, Milliman & Robertson, Inc.
Funding
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Recent Publications
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2013. Incidence and correlates of Chlamydia trachomatis infection in a high-risk cohort of Kenyan women.. Sexually transmitted diseases. 40(3):221-5. Abstract
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2013. Antibody-dependent cell-mediated virus inhibition (ADCVI) antibody activity does not correlate with risk of HIV-1 superinfection.. Journal of acquired immune deficiency syndromes (1999). Abstract
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2013. Appropriateness of hydroxyethylcellulose gel as a placebo control in vaginal microbicide trials: A comparison of the two control arms of HPTN 035.. Journal of acquired immune deficiency syndromes (1999). Abstract
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2013. Lipid Changes in Kenyan HIV-1-Infected Infants Initiating Highly Active Antiretroviral Therapy by One Year of Age.. The Pediatric infectious disease journal. Abstract
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2013. Adherence and Acceptability in MTN 001: A Randomized Cross-Over Trial of Daily Oral and Topical Tenofovir for HIV Prevention in Women.. AIDS and behavior. 17(2):737-747. Abstract
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2012. A pilot study of the feasibility of a vaginal washing cessation intervention among Kenyan female sex workers.. Sexually transmitted infections. Abstract
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2012. Breast milk cellular HIV-specific interferon γ responses are associated with protection from peripartum HIV transmission.. AIDS (London, England). 26(16):2007-16. Abstract
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2012. A Combination of Broadly Neutralizing HIV-1 Monoclonal Antibodies Targeting Distinct Epitopes Effectively Neutralizes Variants Found in Early Infection.. Journal of virology. 86(19):10857-61. Abstract
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2012. HIV-1-Specific Enzyme-Linked Immunosorbent Spot Assay Responses in HIV-1-Exposed Uninfected Partners in Discordant Relationships Compared to Those in Low-Risk Controls.. Clinical and vaccine immunology : CVI. 19(11):1798-805. Abstract
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2012. The posttrial effect of oral periodic presumptive treatment for vaginal infections on the incidence of bacterial vaginosis and Lactobacillus colonization.. Sexually transmitted diseases. 39(5):361-5. Abstract
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2012. Survival Benefit of Early Infant Antiretroviral Therapy is Compromised when Diagnosis is Delayed.. The Pediatric infectious disease journal. 31(7):729-731. Abstract
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2012. Valacyclovir Suppressive Therapy Reduces Plasma and Breast Milk HIV-1 RNA Levels During Pregnancy and Postpartum: A Randomized Trial.. The Journal of infectious diseases. 205(3):366-75. Abstract
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2012. Mucosal Escherichia coli Bactericidal Activity and Immune Mediators Are Associated With HIV-1 Seroconversion in Women Participating in the HPTN 035 Trial.. The Journal of infectious diseases. 206(12):1931-5. Abstract
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2012. Genital Inflammation Predicts HIV-1 Shedding Independent of Plasma Viral Load and Systemic Inflammation.. Journal of acquired immune deficiency syndromes (1999). 61(4):436-40. Abstract
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2012. The Prevalence of Stunting Is High in HIV-1-Exposed Uninfected Infants in Kenya.. The Journal of nutrition. 142(4):757-63. Abstract
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2011. Knowing a sexual partner is HIV-1-uninfected is associated with higher condom use among HIV-1-infected adults in Kenya.. Sexually transmitted diseases. 38(9):808-10. Abstract
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2011. HBV lamivudine resistance among hepatitis B and HIV coinfected patients starting lamivudine, stavudine and nevirapine in Kenya.. Journal of viral hepatitis. 18(10):e447-52. Abstract
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2011. Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004).. AIDS (London, England). 25(8):1057-64. Abstract
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2011. The consequences of post-election violence on antiretroviral HIV therapy in Kenya.. AIDS care. 23(5):562-8. Abstract
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2011. Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapy.. Sexually transmitted infections. 87(2):114-7. Abstract
