Harlan Robins

Appointments and Affiliations
 
 
Fred Hutchinson Cancer Research Center
Computational Biology
Public Health Sciences
Assistant Member, Appointed: 2006
 Professional Headshot of Harlan Robins

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave N.
Public Health Sciences
M2 B876
Seattle, Washington 98109
United States

Contact

Phone: (206) 667-2571
Fax: (206) 667-1319
hrobins@fhcrc.org

Degrees

Ph.D., University of California, Berkeley, Physics, 2001.
M.A., University of California, Berkeley, Physics, 1997.
A.B., Harvard University, Physics, 1995.

Research Interests

My research is computationally based and focuses on the adaptive immune system and its response to viral infection, with HIV a particular area of interest. Taking advantage of new high-throughput sequencing technology, in collaboration with experimental groups, we are isolating and sequencing millions of t-cell receptor VDJ rearrangements from different clonotypes. With this new technology, we can attempt a comprehensive description of the t-cell repertoire and ask what how this repertoire is modified during an immune response.

Previous Positions

2002-2006, Post-doctoral fellow, Institute for Advanced Study, Princeton, NJ
2001-2002, Post-doctoral fellow, Weizmann Institute of Science, Particle Theory Group

 

Recent Publications

2012
Larimore, K, McCormick MW, Robins HS, Greenberg PD.  2012.  Shaping of Human Germline IgH Repertoires Revealed by Deep Sequencing.. Journal of immunology (Baltimore, Md. : 1950). 189(6):3221-30. Abstract
Robins, HS, Desmarais C, Matthis J, Livingston R, Andriesen J, Reijonen H, Carlson CS, Nepom G, Yee C, Cerosaletti K.  2012.  Ultra-sensitive detection of rare T cell clones.. Journal of immunological methods. 375(1-2):14-19. Abstract
Srivastava, SK, Robins HS.  2012.  Palindromic nucleotide analysis in human T cell receptor rearrangements.. PloS one. 7(12):e52250. Abstract
2011
Sherwood, AM, Desmarais C, Livingston RJ, Andriesen J, Haussler M, Carlson CS, Robins HS.  2011.  Deep sequencing of the human TCRγ and TCRβ repertoires suggests that TCRβ rearranges after αβ and γδ T cell commitment.. Science translational medicine. 3(90):90ra61. Abstract
Robins, HS.  2011.  Detecting and monitoring lymphoma with high-throughput sequencing.. Oncotarget. 2(4):287-8.
2010
Robins, HS, Srivastava SK, Campregher PV, Turtle CJ, Andriesen J, Riddell SR, Carlson CS, Warren EH.  2010.  Overlap and effective size of the human CD8+ T cell receptor repertoire.. Science translational medicine. 2(47):47ra64. Abstract
Campregher, PV, Srivastava SK, Deeg HJ, Robins HS, Warren EH.  2010.  Abnormalities of the alphabeta T-cell receptor repertoire in advanced myelodysplastic syndrome.. Experimental hematology. 38(3):202-12. Abstract
2009
Robins, HS, Campregher PV, Srivastava SK, Wacher A, Turtle CJ, Kahsai O, Riddell SR, Warren EH, Carlson CS.  2009.  Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.. Blood. 114(19):4099-107. Abstract
2008
Robins, HS, Krasnitz M, Levine AJ.  2008.  The computational detection of functional nucleotide sequence motifs in the coding regions of organisms.. Experimental biology and medicine (Maywood, N.J.). 233(6):665-73. Abstract
Murphy, E, Vanícek J, Robins HS, Shenk T, Levine AJ.  2008.  Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency.. Proceedings of the National Academy of Sciences of the United States of America. 105(14):5453-8. Abstract
Huang, Y, Krasnitz M, Rabadan R, Witten DM, Song Y, Levine AJ, Ho DD, Robins HS.  2008.  A recoding method to improve the humoral immune response to an HIV DNA vaccine.. PloS one. 3(9):e3214. Abstract