George E. Sale

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research Division
 
University of Washington
School of Medicine
Pathology
Professor, Appointed: 1988
Professional Headshot of George E. Sale

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Avenue N., G1-309
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Contact

Phone: (206) 288-1352
Fax: (206) 288-1345
gsale@fhcrc.org

Degrees

M.D., Stanford University, 1968.

Research Interests

As a pathologist with the Seattle bone marrow transplant team I am interested in human and experimental bone marrow transplantation immunobiology with special reference to graft versus host disease in humans and animals. Graft rejection and transplantation tolerance as reflected in vivo are areas I study in collaboration with colleagues in Transplantation Biology (Drs. Storb, Yunusov,and Kuhr). Cytotoxic lymphocytes subserve a mechanism of tissue damage I am particularly interested in exploring. Epidermal biology with special reference to epidermal stem cells of the parafollicular bulge and the rete ridge are a focus of my hypotheses regarding pathogenesis of graft versus host disease, graft rejection, and autoimmune diseases.

I have also become interested in newer methods of the study of the hematopathology of human bone marrow with multiparameter flow fluorocytometry. Another area of current work is the correlation of marrow histology with magnetic resonance imaging of the pelvic , femoral and vertebral bone marrow for accurate grading of myelofibrosis in humans.

Additional Experience

Special Local Responsibilities:
1991, Co-Director (Syllabus editor) of Systemic Pathology Course (HuBio 546), University of Washington, Dept. of Pathology, Seattle, Washington, with Dr. Rodney Schmidt.

Honors and Society Memberships:
1986, 1993, Who's Who in the West;
1986 to Date, American Association of Pathologists;
1983 to Date, American Association for the Adv. of Science;
1981 to Date, International Academy of Pathology;
1977 - 1984, International Society for Experimental Hematology;
1977to date, Northwest Society of Pathologists.

Future Research

Correlation of MRI (magnetic resonance imaging ) with marrow histology to better assess myelofibrosis in stem cell transplant patients. Tolerance in stem cell and solid organ transplantation with mixed chimerism.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)
French: (Basic, None, None)

Memberships

College of American Pathologists
International Academy of Pathology
International Physicians for the Prevention of Nuclear War
Physicians for Social Responsibility

Previous Positions

1982-1988, Associate Professor of Pathology, School of Medicine, School of Medicine
1991-present, Fred Hutchinson Cancer Research Center, Seattle, Washington, Member
1983-1991, Fred Hutchinson Cancer Research Center, Seattle, Washington, Associate Member
1982-present, Veterans Admin. Hospital Marrow Transplant Program, Seattle, Washington, Consultant Pathologist
1978-1983, Fred Hutchinson Cancer Research Center, Seattle, Washington, Assistant Member\

Funding

  • National Institutes of Health (NIH): Pathology Core sections of Adult Leukemia Center Program Project Grant and Stem cell transplant for nonmalignant disorders programroject grant, F. Appelbaum and R. Storb, respective PI's

 

Recent Publications

2014
2013
2012
2011
2010
2009
2008
2003