George E. Sale

As a pathologist with the Seattle bone marrow transplant team I am interested in human and experimental bone marrow transplantation immunobiology with special reference to graft versus host disease in humans and animals. Graft rejection and transplantation tolerance as reflected in vivo are areas I study in collaboration with colleagues in Transplantation Biology (Drs. Storb, Yunusov,and Kuhr). Cytotoxic lymphocytes subserve a mechanism of tissue damage I am particularly interested in exploring. Epidermal biology with special reference to epidermal stem cells of the parafollicular bulge and the rete ridge are a focus of my hypotheses regarding pathogenesis of graft versus host disease, graft rejection, and autoimmune diseases.

I have also become interested in newer methods of the study of the hematopathology of human bone marrow with multiparameter flow fluorocytometry. Another area of current work is the correlation of marrow histology with magnetic resonance imaging of the pelvic , femoral and vertebral bone marrow for accurate grading of myelofibrosis in humans.

Special Local Responsibilities:
1991, Co-Director (Syllabus editor) of Systemic Pathology Course (HuBio 546), University of Washington, Dept. of Pathology, Seattle, Washington, with Dr. Rodney Schmidt.

Honors and Society Memberships:
1986, 1993, Who's Who in the West;
1986 to Date, American Association of Pathologists;
1983 to Date, American Association for the Adv. of Science;
1981 to Date, International Academy of Pathology;
1977 - 1984, International Society for Experimental Hematology;
1977to date, Northwest Society of Pathologists.

Correlation of MRI (magnetic resonance imaging ) with marrow histology to better assess myelofibrosis in stem cell transplant patients. Tolerance in stem cell and solid organ transplantation with mixed chimerism.