Jean E. Sanders

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Clinical Research
Member
University of Washington
School of Medicine
Pediatrics
Gerald and Gloria Swanson Endowed Chair, Appointed: 2005
University of Washington
School of Medicine
Pediatrics
Professor, Appointed: 1990
University of Washington
School of Medicine
Pediatrics
Clinical Pediatric Hematopoietic Cell Transplantation
Director, Appointed: 1990
Professional Headshot of Jean E. Sanders

Mailing Address

Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N, D5-280
P.O. Box 19024
Seattle, Washington 98109-1024
United States

Degrees

M.D., University of Iowa, Medicine, 1970.
Diploma, Mihadol University, Tropical Medicine, 1970.
B.A., Simpson College, 1966.

Research Interests

Pediatric hematopoietic stem cell transplantation is my major area of expertise. I have been involved in the transplantation of all children at the Fred Hutchinson Cancer Research Center for more than 28 years. In addition, I have worked to design transplant preparative regimens for children with acute lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia and other hematologic malignancies, pediatric solid tumors including neuroblastoma, Ewing's sarcoma and aplastic anemia, and other non-malignant hematologic disorders. Donor selection for transplantation of these children using a matched family member, an unrelated marrow of peripheral blood stem cell donor, or an umbilical cord blood donor, is another area of involvement.

My major area of research interest is in long-term follow-up issues of children surviving after hematopoietic stem cell transplantation. These issues include chronic graft versus host disease, recurrent leukemia, growth and development problems, and other late effects. My studies demonstrate that some patients who relapse after their first transplant may have a successful second transplant, particularly those whose first transplant preparative regimen was chemotherapy based. These patients do very well with a second transplant that uses a total body irradiation based preparative regimen. Patients who relapse after an initial transplant using a total body irradiation based preparative regimen, however, fare poorly after second transplant. My research studies demonstrate that children who receive total body irradiation have significant problems with delayed growth and growth hormone deficiency occurs in approximately 80% of children. Use of growth hormone to promote subsequent growth appears to benefit these children. Our research studies demonstrate that puberty is delayed among children who receive total body irradiation and this delay is most evident in children who are in the peri-pubertal age group at the time of transplantation. Other late effects are being found through our research efforts. Some of these problems include diabetes mellitus, decreased bone mineral density, development of a substantial number of fractures, and pulmonary function abnormalities. Quality of life studies demonstrate that when these children become adults they experience an increased number of medical problems compared to their normal peers and have a greater difficulty obtaining insurance.

Additional Experience

I developed and conduct, a weekly chronic graft-versus-host-disease clinic for children who live in, or travel to, the greater Seattle area, and who are interested in coming to this clinic for management of their chronic graft-versus-host-disease. The care we provide is directed at management of the patient's chronic graft-versus-host-disease and is done in conjunction with the patient's primary care physician from their local community. Twenty-five to 30 patients are active in this clinic at any one time. In addition to the chronic graft-versus-host-disease clinic that is held at the Seattle Cancer Care Alliance, I also conduct a long-term follow-up outreach clinic twice a year at Deaconess Hospital in Spokane, Washington. This clinic primarily seespatients with chronic graft-versus-host-disease.

Future Research

Future research studies will be directed toward development of interventions to minimize or treat, some of the delayed effects. One intervention may include a more timely initiation of therapy with growth hormone to promote greater growth and maximize final height achieved. Another intervention could include use of agents to minimize the severity of osteoporosis and hence minimize fracture risks after transplant. The development of a greater understanding of the delayed impact of the preparative regimen on pulmonary function may lead to innovative interventions. For patients who relapse after an initial transplant using a total body irradiation preparative regimen, prospective studies are evaluating the use of a non-myeloablative preparative regimen for second transplant. Treatment protocols are being developed for patients with challenging chronic graft-versus-host-disease.

Languages

(Reading, Writing, Speaking)

English: (Fluent, Fluent, Fluent)

Memberships

American Academy of Pediatrics
American Society for Blood and Bone Marrow Transplantation
American Society for Clinical Oncology
American Society of Pediaric Hematology Oncology
Children's Oncology Group
International Society of Experimental Hematology
Society for Pediatric Research

Honors and Awards

1978, Distinguished Young Alumni Award, Simpson College, Indianola, Iowa

Previous Positions

1983-1990, Associate Member, Fred Hutchinson Cancer Research Center, Clinical Research
1983-1990, Associate Professor, University of Washington, School of Medicine, Pediatrics
1979-1983, Assistant Member, Fred Hutchinson Cancer Research Center, Clinical Research
1978-1983, Associate, Fred Hutchinson Cancer Research Center, Clinical Research
1978-1983, Assistant Professor, University of Washington, School of Medicine, Pediatrics
1975-1978, Instructor, University of Washington, School of Medicine, Pediatrics
1973-1975, Fellow/Senior Fellow, Children's Hospital at Stanford, School of Medicine, Oncology

Recent Publications

2014
2012
2011
Woodard, P, Carpenter PA, Davies SM, Gross TG, He W, Zhang M-J, Horn BN, Margolis DA, Perentesis JP, Sanders JE et al..  2011.  Unrelated donor bone marrow transplantation for myelodysplastic syndrome in children.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(5):723-8. Abstract
2010
Gross, TG, Hale GA, He W, Camitta BM, Sanders JE, Cairo MS, Hayashi RJ, Termuhlen AM, Zhang M-J, Davies SM et al..  2010.  Hematopoietic stem cell transplantation for refractory or recurrent non-Hodgkin lymphoma in children and adolescents.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 16(2):223-30. Abstract
Walters, MC, Hardy K, Edwards S, Adamkiewicz T, Barkovich J, Bernaudin F, Buchanan GR, Bunin N, Dickerhoff R, Giller R et al..  2010.  Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 16(2):263-72. Abstract
Chow, EJ, Simmons JH, Roth CL, Baker KS, Hoffmeister PA, Sanders JE, Friedman DL.  2010.  Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 16(12):1674-81. Abstract
Hoffmeister, PA, Hingorani SR, Storer BE, Baker KS, Sanders JE.  2010.  Hypertension in long-term survivors of pediatric hematopoietic cell transplantation.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 16(4):515-24. Abstract
2009