William H. Schubach

Appointments and Affiliations

 
 
VA Puget Sound Health Care System
Medicine
Oncology
Medical Oncology
Director, Appointed: 1993
University of Washington
School of Medicine
Medicine
Oncology
Associate Professor, Appointed: 1994
Fred Hutchinson Cancer Research Center
Clinical Research Division
 
Professional Headshot of William H. Schubach

Mailing Address

Box 358280
University of Washington
Seattle, Washington 98195
United States

Contact

Phone: (206) 764-2709
Fax: (206) 764-2851
wschu@u.washington.edu

Degrees

M.D., Columbia University, 1974.
Ph.D., University of California, Santa Cruz, 1971.

Research Interests

Epstein-Barr virus (EBV)is implicated in several human cancers but is causative of polyclonal and monoclonal B cell malignancies that occur in immunosupressed people. My laboratory is studying the multiprotein complexes involved in B cell immortaliztionby EBV with emphasis on the role played by the Epstein-Barr nuclear protein 2. We are studying the role of the human SWI/SNF chromatin remodeling complex in transcription regulation by EBV. In addition, we have found that EBNA2 modulates the activity ofa number of other proteins involved in gene expression and cell division. Our lab is studying these interactions and their roles in virus-induced B cell immortalization.

Memberships

American Society of Hematology
American Society of Microbiology

Funding

  • National Institutes of Health (NIH): Chromatin Remodeling and Viral Transformation, $375,000, Aug 1, 2000 to Jul 31, 2003.
  • Department of Veterans Affairs-Merit Review: Control Factors in Lymphocyte Development, $420,000, Apr 1, 2000 to Mar 31, 2003.