Stephen M. Schwartz
Ph.D., University of Washington, Epidemiology, 1990.
M.P.H., Yale University, Epidemiology, 1984.
B.A., University of Virginia, Biology, 1981.
The following paragraphs provide summaries of my research interests. More details can be found on my webpage, listed above.
My studies of the molecular epidemiology of oral squamous cell carcinoma (OSCC) explore the interplay of genetic, virologic, and lifestyle characteristics in both the etiology and prognosis of these cancers. Using data from a population-based case-control study, we have found that the risk of OSCC was related to serologic evidence of both HPV and HSV1 infection, particularly among cigarette smokers. In addition, we found that the detection of HPV DNA in OSCC is related to favorable patient survival. We are currently examining whether OSCC is related to polymorphisms in a variety of genes that are known or suspected of mediating the consequences of tobacco, alcohol, and viral exposures. Examples of genes we have or will study include GSTM1, GSTT1, GSTP1, CYP2E1, NQO1, NAT1, NAT2, EPHX, ADH3, XRCC3, XRCC1, AGT, and XPD. The results should enhance our knowledge of the interaction of environmental and inherited susceptibility to OSCC.
As part of a Program Project Grant headed by James McDougall, Ph.D., (Cancer Biology Program, FHCRC), I am studying factors related to the prognosis of cervical and other genital cancers. Our goal is to identify tumor markers and other characteristics that in the future may help clinicians predict which patients will develop recurrences and, potentially, target the application of therapies to women at highest risk of relapse. We have found that patients with HPV18-related cervical cancers have reduced survival, and recent immunohistochemical analyses of these tumors suggests that the combination of high cyclin E expression and HPV18 is associated with a particularly poor prognosis.
I have continued my long-standing interest in the etiology of uterine leiomyomata ("fibroids"). Leiomyomata are among the most common neoplasms that develop among women, and although benign, are the leading non-malignant indication for hysterectomy among pre-menopausalwomen. TULEP (The Uterine Leiomyomata Epidemiology Project) is a population-based case-control study we conducted to identify hormonal and hormonally-mediated risk factors for uterine leiomyomata, In addition to an extensive in-person interview focusing on lifestyle, medical, and reproductive characteristics, we collected biologic specimens to determine whether the risk of leiomyomata is related to: (1) urinary excretion of phytoestrogens (lignans, isoflavones); (2) serum organochlorine pesticideand polychlorinated biphenyl residues; and (3) germline polymorphisms in enzymes involved in hormone synthesis and metabolism.
I am conducting a population-based case-control study to test the hypothesis that inherited variation in genes involved in stimulating testicular steroidogenesis, synthesizing and metabolizing testosterone, and androgen signaling, is related to the risk of developing testicular germ cell carcinoma (TGCC). In addition to examining gene-gene interactions using the case-control data, we are studying whether blood levels of putative endocrine disrupting chemicals, such as p,p-DDE, pose an increased risk of TGCC among carriers of putative TGCC susceptibility alleles (e.g., large numbers of CAG repeats in the Androgen Receptor gene). We also are employing a case-parent triad design (by recruiting the mothers and fathers of our TGCC cases) to test the hypothesis that maternal carriership of susceptibility alleles in steroid metabolism and growth factor genes are related to TGCC risk.
American Association for Cancer Research
Society for Epidemiologic Research
1996-2002, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1995-1996, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1990-1995, Affiliate Investigator, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1990-1996, Assistant Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1989-1989, Instructor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1985-1990, Research Associate, Fred Hutchinson Cancer Research Center, Epidemiology
1984-1985, Research Associate, Fred Hutchinson Cancer Research Center, Cancer Surveillance System
Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23.. Human molecular genetics.. 2013.
A 13-Gene Signature Prognostic of HPV-Negative OSCC: Discovery and External Validation.. Clinical cancer research : an official journal of the American Association for Cancer Research. 19(5):1197-203.. 2013.
A history of allergies is associated with reduced risk of oral squamous cell carcinoma.. Cancer causes & control : CCC.. 2012.
Prepregnancy Body Mass Index and Congenital Heart Defects among Offspring: A Population-based Study.. Congenital heart disease.. 2012.
Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium.. International journal of cancer. Journal international du cancer. 131(7):1686-99.. 2012.
Cohort Profile: The Skin Cancer After Organ Transplant Study.. International journal of epidemiology.. 2012.
Rates and determinants of oral human papillomavirus infection in young men.. Sexually transmitted diseases. 39(11):860-7.. 2012.
Genetic variation in CD83 and risks of cervical and vulvar cancers: A population-based case-control study.. Gynecologic oncology. 124(3):525-528.. 2012.
No association between antibodies to sexually transmitted infections and colorectal hyperplastic polyps in men: Minnesota Cancer Prevention Research Unit Polyp Study.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.. 2012.
Impact of cancer on work and education among adolescent and young adult cancer survivors.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(19):2393-400.. 2012.
Human Papillomavirus-Positive Oral Cavity and Oropharyngeal Cancer Patients Do Not Have Better Quality-of-Life Trajectories.. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2012.
Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium.. Cancer causes & control : CCC. 23(1):69-88.. 2012.
History of Diabetes and Risk of Head and Neck Cancer: A Pooled Analysis from the International Head and Neck Cancer Epidemiology Consortium.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 21(2):294-304.. 2012.
Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: A hybrid case-parent triad and case-control study.. International journal of cancer. Journal international du cancer.. 2012.
Maternal, perinatal, and postneonatal outcomes in women with chronic heart disease in Washington State.. Obstetrics and gynecology. 120(6):1283-90.. 2012.
Integrative Analysis in Oral Squamous Cell Carcinoma Reveals DNA Copy Number-Associated miRNAs Dysregulating Target Genes.. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2012.
Hypothesis-Based Analysis of Gene-Gene Interactions and Risk of Myocardial Infarction.. PloS one. 7(8):e41730.. 2012.
Recruitment and follow-up of adolescent and young adult cancer survivors: the AYA HOPE Study.. Journal of cancer survivorship : research and practice. 5(3):305-314.. 2011.
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.. Nature. 478(7367):103-9.. 2011.
No Evidence for Human Papillomavirus in the Etiology of Colorectal Polyps.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 20(10):2288-97.. 2011.