Stephen M. Schwartz
Ph.D., University of Washington, Epidemiology, 1990.
M.P.H., Yale University, Epidemiology, 1984.
B.A., University of Virginia, Biology, 1981.
The following paragraphs provide summaries of my research interests. More details can be found on my webpage, listed above.
My studies of the molecular epidemiology of oral squamous cell carcinoma (OSCC) explore the interplay of genetic, virologic, and lifestyle characteristics in both the etiology and prognosis of these cancers. Using data from a population-based case-control study, we have found that the risk of OSCC was related to serologic evidence of both HPV and HSV1 infection, particularly among cigarette smokers. In addition, we found that the detection of HPV DNA in OSCC is related to favorable patient survival. We are currently examining whether OSCC is related to polymorphisms in a variety of genes that are known or suspected of mediating the consequences of tobacco, alcohol, and viral exposures. Examples of genes we have or will study include GSTM1, GSTT1, GSTP1, CYP2E1, NQO1, NAT1, NAT2, EPHX, ADH3, XRCC3, XRCC1, AGT, and XPD. The results should enhance our knowledge of the interaction of environmental and inherited susceptibility to OSCC.
As part of a Program Project Grant headed by James McDougall, Ph.D., (Cancer Biology Program, FHCRC), I am studying factors related to the prognosis of cervical and other genital cancers. Our goal is to identify tumor markers and other characteristics that in the future may help clinicians predict which patients will develop recurrences and, potentially, target the application of therapies to women at highest risk of relapse. We have found that patients with HPV18-related cervical cancers have reduced survival, and recent immunohistochemical analyses of these tumors suggests that the combination of high cyclin E expression and HPV18 is associated with a particularly poor prognosis.
I have continued my long-standing interest in the etiology of uterine leiomyomata ("fibroids"). Leiomyomata are among the most common neoplasms that develop among women, and although benign, are the leading non-malignant indication for hysterectomy among pre-menopausalwomen. TULEP (The Uterine Leiomyomata Epidemiology Project) is a population-based case-control study we conducted to identify hormonal and hormonally-mediated risk factors for uterine leiomyomata, In addition to an extensive in-person interview focusing on lifestyle, medical, and reproductive characteristics, we collected biologic specimens to determine whether the risk of leiomyomata is related to: (1) urinary excretion of phytoestrogens (lignans, isoflavones); (2) serum organochlorine pesticideand polychlorinated biphenyl residues; and (3) germline polymorphisms in enzymes involved in hormone synthesis and metabolism.
I am conducting a population-based case-control study to test the hypothesis that inherited variation in genes involved in stimulating testicular steroidogenesis, synthesizing and metabolizing testosterone, and androgen signaling, is related to the risk of developing testicular germ cell carcinoma (TGCC). In addition to examining gene-gene interactions using the case-control data, we are studying whether blood levels of putative endocrine disrupting chemicals, such as p,p-DDE, pose an increased risk of TGCC among carriers of putative TGCC susceptibility alleles (e.g., large numbers of CAG repeats in the Androgen Receptor gene). We also are employing a case-parent triad design (by recruiting the mothers and fathers of our TGCC cases) to test the hypothesis that maternal carriership of susceptibility alleles in steroid metabolism and growth factor genes are related to TGCC risk.
American Association for Cancer Research
Society for Epidemiologic Research
1996-2002, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1995-1996, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1990-1995, Affiliate Investigator, Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Epidemiology
1990-1996, Assistant Professor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1989-1989, Instructor, University of Washington, School of Public Health and Community Medicine, Epidemiology
1985-1990, Research Associate, Fred Hutchinson Cancer Research Center, Epidemiology
1984-1985, Research Associate, Fred Hutchinson Cancer Research Center, Cancer Surveillance System
Short-term natural history of high-risk human papillomavirus infection in mid-adult women sampled monthly.. International journal of cancer. Journal international du cancer.. 2015.
Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization.. Cancer causes & control : CCC. 26(3):467-73.. 2015.
Association of history of allergies and influenza-like infections with laryngeal cancer in a case-control study.. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.. 2015.
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.. Nature. 518(7537):102-6.. 2015.
Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium.. International journal of epidemiology. 44(1):169-85.. 2015.
Risk of congenital heart defects in the offspring of smoking mothers: a population-based study.. The Journal of pediatrics. 166(4):978-984.e2.. 2015.
Inactivating mutations in NPC1L1 and protection from coronary heart disease.. The New England journal of medicine. 371(22):2072-82.. 2014.
Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries.. International journal of cancer. Journal international du cancer.. 2014.
Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium.. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 23(1):160-71.. 2014.
Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness: the Coronary Artery Risk Development in Young Adults Women's study.. Arteriosclerosis, thrombosis, and vascular biology. 34(12):2688-94.. 2014.
Human Leukocyte Antigen Class I and II Alleles and Cervical Adenocarcinoma.. Frontiers in oncology. 4:119.. 2014.
Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium.. European journal of epidemiology.. 2013.
Meta-analysis identifies four new loci associated with testicular germ cell tumor.. Nature genetics. 45(6):680-5.. 2013.
A 13-Gene Signature Prognostic of HPV-Negative OSCC: Discovery and External Validation.. Clinical cancer research : an official journal of the American Association for Cancer Research. 19(5):1197-203.. 2013.
Talking About Cancer and Meeting Peer Survivors: Social Information Needs of Adolescents and Young Adults Diagnosed with Cancer.. Journal of adolescent and young adult oncology. 2(2):44-52.. 2013.
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.. The American journal of clinical nutrition.. 2013.
Genetic variation in the TLR and NF-κB pathways and cervical and vulvar cancer risk: A population-based case-control study.. International journal of cancer. Journal international du cancer.. 2013.
Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23.. Human molecular genetics. 22(13):2748-2753.. 2013.