Steven G. Self

Appointments and Affiliations

 
 
Fred Hutchinson Cancer Research Center
Vaccine and Infectious Disease Institute (VIDI)
Associate Director, Appointed: 2007
Fred Hutchinson Cancer Research Center
Statistical Center for HIV/AIDS Research and Prevention (SCHARP)
Executive Director, Appointed: 2004
HIV Vaccine Trials Network
Statistical and Data Management Center
Director, Appointed: 2000
Fred Hutchinson Cancer Research Center
Public Health Sciences Division
Biostatistics and Biomathematics
Program Head and Member, Appointed: 1994
University of Washington
School of Public Health and Community Medicine
Biostatistics
Professor, Appointed: 1991
Professional Headshot of Steven G. Self

Mailing Address

1100 Fairview Ave. N, M2-C200
Fred Hutchinson Cancer Research Center
PO Box 19024
Seattle, Washington 98109-1024
United States

Contact

Degrees

Ph.D., University of Washington, Biostatistics, 1981.
M.S., California State University, Biology, 1977.

Research Interests

The HIV epidemic continues to grow worldwide despite major advances in understanding the pathogenesis of HIV infection and in our ability to treat the disease. Control of the epidemic requires improved methods and strategies for preventing HIV infection. An HIV vaccine that is simple to administer, inexpensive and that induces long-lasting immunity to all known HIV strains would be the optimal preventive measure. The thorough and efficient clinical evaluation of HIV vaccine candidates presents many scientific and operational challenges. There are multiple mechanisms through which an HIV vaccine might be effective and clinical trials must be designed to assess each potential mechanism; there are significant global heterogeneities in human and viral populations for which an HIV vaccine is needed and a program of clinical trials must be designed to assess the impact of these heterogeneities on vaccine effectiveness; the most appropriate settings for clinical evaluation of HIV vaccines are ones which typically lack existing infrastructure to support rigorous clinical research so that such infrastructure must be developed as part of the clinical evaluation program.

The focus of my research is: 1) the design, coordination and analysis of a clinical trials program to evaluate promising candidate HIV vaccines and 2) the development of new statistical study designs and analytic techniques that will increase the efficiency of those evaluations. The coordination of field trials is performed largely throughactivities of the Statistical Center for HIV/AIDS Research and Prevention (SCHARP). SCHARP is composed of statistical coordinating centers for international NIH-funded clinical research networks including the HIV Vaccine Trials Network (HVTN) and the HIVPrevention Trials Network (HPTN. I serve as Co-Director of SCHARP. There are also methodological research groups working on biomathematical modeling of HIV infection dynamics and development of new statistical methods within SCHARP. Topics of current methodologic research include the use of interacting branching processes to model the early events of HIV infection and the potential for vaccines to impact the course of infection by changes in the dynamics of these processes, the development of efficient designs of Phase I/II vaccine trials for optimization of vaccination regimens over dose, schedule and route of administration, the development of statistical methods for the analysis and interpretation of new assays for cellular immune response, the development of new statistical methods for the analysis of effects of human and viral heterogeneity on vaccine efficacy and the use of post-infection biomarker data to assess potential vaccine effects on disease progression and secondary transmission.

Memberships

American Statistical Association Society for Clinical Trials
NCI Board of Scientific Counselors

Previous Positions

1986-1991, Associate Professor, University of Washington, Department of Biostatistics
1986-1989, Associate Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division
1984-1986, Assistant Professor, University of Washington, Department of Biostatistics
1984-1986, Assistant Member, Fred Hutchinson Cancer Research Center, Public Health Sciences Division
1983, Visiting Scientist, Rothamsted Experimental Station, UK, Department of Statistics
1982, Assistant Professor of Oncology, Johns Hopkins University, School of Medicine, Oncology Center
1981-1984, Assistant Professor, Johns Hopkins University, Bloomberg School of Public Health, Department of Biostatistics
1980-1981, Statistical Research Associate, Fred Hutchinson Cancer Research Center
1979, Teaching Assistant, University of Washington
1977-1978, Research Assistant, Seattle Heart Watch
1975-1977, Teaching Assistant, California State University, Long Beach
1984-present, Adjunct Professor, Johns Hopkins University, Bloomberg School of Public Health, Department of Biostatistics

 

Recent Publications

2014
2013
2012
2011
2010
2009