M.D., Albert Einstein College of Medicine, Medicine, 1981.
Ph.D., Brooklyn College, The City University of New York, Literature.
Dr. Steinbach's research is focused on gastrointestinal cancer prevention, including genetic and clinical predisposition, chemoprevention, and early detection. The work is based on multidisciplinary and inter-institutional collaborations. Recent collaborative studies investigated the role of aspirin in the prevention of colorectal adenomatous polyps in persons with previous colorectal tumors and the effect of cyclooxygenase-2 inhibition on colorectal adenomatous polyps in patients with FAP (an inherited predisposition to colorectal adenomas). The latter was the first clinical trial to investigate the effect of COX-2 inhibition on a human tumor. Demonstration of efficacy on adenomatous polyps in FAP provided support for initiating trials of COX-2 inhibition for the control of sporadic colon tumors and other tumors that express COX-2.
Blood and gastric FOXP3+ T cells are not decreased in human gastric graft-versus-host disease.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(4):486-96.. 2011.
Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells.. Digestive diseases and sciences. 55(5):1396-405.. 2010.
Defibrotide for the treatment of severe hepatic veno-occlusive disease and multiorgan failure after stem cell transplantation: a multicenter, randomized, dose-finding trial.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 16(7):1005-17.. 2010.
NCCN clinical practice guidelines in oncology. Colorectal cancer screening.. Journal of the National Comprehensive Cancer Network : JNCCN. 8(1):8-61.. 2010.
Gastrointestinal infections after solid organ or hematopoietic cell transplantation. Transplant Infections. :236-255.. 2010.