Karen L. Syrjala
Postdoctoral Fellowship, University of Washington and Fred Hutchinson Cancer Research Center, Pain/Behavioral Medicine, 1985.
Ph.D., Boston University, Clinical Psychology, 1983.
M.A., Boston University, Clinical Psychology, 1980.
B.A., Wellesley College, Psychology and English, 1973.
My research has focused on defining long term and late complications of hematopoietic stem cell transplantation, clinical trials to improve outcomes during and after cancer treatment, cancer pain and symptom management, and opioid side effects. As we know, cancer not only attacks organ systems, but also influences neuroendocrine function, neurocognitive function and, directly or indirectly, affects emotions, thinking, behaviors, physical symptoms, family systems - in short the whole person. Our Biobehavioral Sciences research investigates methods of integrating behavioral and biological treatments, with goals of 1) optimizing patients' participation in their own care, 2) reducing symptoms and complications of treatment or the disease, and 3) improving long term outcomes.
At the Center, our research first designed and tested interventions to treat the most common symptoms during cancer treatment. Targeted symptoms included pain, stress and nausea/emesis. Methods included hypnosis, imagery and coping skills training combined with patient-controlled-analgesia. As our research progressed, we identified needs for cancer patients with pain to better understand their treatments, and needs for better scientific understanding of opioid side effects so that cancer patients could receive effective pain relief. Our longitudinal prospective studies out to 10 years have also identified problems in cancer survivors that require more actively integrated medical and behavioral treatments. These problems included long term fatigue, cognitive deficits, and hormone-related outcomes such as menopausal symptoms and sexual dysfunction. All of our intervention research is tested through randomized controlled clinical trials, with interdisciplinary collaborators. In a multi-site trial to enhance recovery after high dose treatment, we have tested interventions provided by telephone, along with print and video materials, to patients around the country. This is the second step in our trials to improve outcomes one to five years after treatment. Other trials examine Internet-based methods for improving communication and surveillance of complications for cancer patients and caregivers.
To achieve our goals of providing cost-effective and time-conserving methods for physicians, nurses, psychologists and other health care providers to treat cancer-related problems, we have developed videotapes and print materials for patients and family members. These materials educate patients and family members living with treatment effects (Relieving Cancer Pain, Focus Forward: Life after Transplant). Dr. Syrjala also has participated in developing guidelines for treating cancer pain including those by the American Pain Society and the National Comprehensive Cancer Network.
Measures have been needed that adequately assess symptoms so that we can effectively determine appropriate treatment and assess outcomes. We have developed a number of self-report tools for this purpose: Patient Cancer and Treatment Distress; Caregiver Cancer and Treatment Distress, Sexual Function Questionnaire, Family & Work Function, Somatic Side Effects of Opioids, Cognitive & Affective Side Effects of Opioids.
All of this biobehavioral research is interdisciplinary, integrating psychology and psychiatry investigators with our colleagues in pharmacology, anesthesiology, oncology, neurosciences, and rehabilitation medicine.
American Pain Society
American Psycho-social Oncology Society
American Psychological Association
International Association for the Study of Pain
Society of Behavioral Medicine
Post-Doctoral Fellowship, Pain & Behavioral Medicine, Anesthesiology, Multidisciplinary Pain Center, 1985
Delivering care to long-term adult survivors of hematopoietic cell transplantation.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 30(30):3746-51.. 2012.
Expressive talking among caregivers of hematopoietic stem cell transplant survivors: acceptability and concurrent subjective, objective, and physiologic indicators of emotion.. Journal of psychosocial oncology. 30(3):294-315.. 2012.
Community-based exercise program effectiveness and safety for cancer survivors.. Journal of cancer survivorship : research and practice. 6(20):219-228.. 2012.
Factors associated with parental activation in pediatric hematopoietic stem cell transplant.. Medical care research and review : MCRR. 69(2):194-214.. 2012.
Hypnosis for symptom management in women with breast cancer: a pilot study.. The International journal of clinical and experimental hypnosis. 60(2):135-59.. 2012.
Systematic review of psychosocial morbidities among bereaved parents of children with cancer.. Pediatric blood & cancer. 58(4):504-512.. 2012.
Adult cancer survivorship care: experiences from the LIVESTRONG centers of excellence network.. Journal of cancer survivorship : research and practice. 5(3):271-82.. 2011.
Development and implementation of an Internet-based survivorship care program for cancer survivors treated with hematopoietic stem cell transplantation.. Journal of cancer survivorship : research and practice. 5(3):292-304.. 2011.
Sexual functioning in obese adults enrolling in a weight loss study.. Journal of sex & marital therapy. 37(3):224-35.. 2011.
Pre- and post-transplantation risk factors for delirium onset and severity in patients undergoing hematopoietic stem-cell transplantation.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 29(7):895-901.. 2011.
Development and validation of 11 symptom indexes to evaluate response to chemotherapy for advanced cancer.. Journal of the National Comprehensive Cancer Network : JNCCN. 9(3):268-78.. 2011.
Factors associated with adherence to preventive care practices among hematopoietic cell transplantation survivors.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 17(7):995-1003.. 2011.
A new index of priority symptoms in advanced ovarian cancer.. Gynecologic oncology. 120(2):214-9.. 2011.
How confident are young adult cancer survivors in managing their survivorship care? A report from the LIVESTRONG™ Survivorship Center of Excellence Network. Journal of cancer survivorship : research and practice. 5(4):371-81.. 2011.
Survivorship care planning after the Institute of Medicine recommendations: how are we faring? Journal of cancer survivorship : research and practice. 5(4):358-370.. 2011.
Adult cancer pain.. Journal of the National Comprehensive Cancer Network : JNCCN. 8(9):1046-86.. 2010.
Measuring musculoskeletal symptoms in cancer survivors who receive hematopoietic cell transplantation.. Journal of cancer survivorship : research and practice. 4(3):225-35.. 2010.
Prospective predictors of return to work in the 5 years after hematopoietic cell transplantation.. Journal of cancer survivorship : research and practice. 4(1):33-44.. 2010.
Impact of delirium on distress, health-related quality of life, and cognition 6 months and 1 year after hematopoietic cell transplant.. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 16(6):824-31.. 2010.
Impact of delirium on decision-making capacity after hematopoietic stem-cell transplantation.. Psychosomatics. 51(4):320-9.. 2010.
Pain in long-term breast cancer survivors: frequency, severity, and impact.. Pain medicine (Malden, Mass.). 11(7):1099-106.. 2010.
Life expectancy in patients surviving more than 5 years after hematopoietic cell transplantation.. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 28(6):1011-6.. 2010.